Relation of Coronary Collateral Circulation With Red Cell Distribution Width in Patients With Non-ST Elevation Myocardial Infarction

Tanboğa, İbrahi̇m Hali̇l; Topçu, Selim; Nacar, Tuncer; Aksakal, Enbiya; Kalkan, Kamuran; Kıkı, İlhami; Sevimli, Serdar

doi:10.1177/1076029612470490

Cited by 15 publications

(17 citation statements)

References 25 publications

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“…In keeping with this, Cecchi et al demonstrated an association between blood viscosity and infarct size in patients with ST-segment elevation MI undergoing primary percutaneous coronary intervention 20. Furthermore, elevated RDW was shown to be an independent predictor of impaired coronary collateral circulation in patients with non-ST elevation MI21 as well as slow coronary flow 22. Microvascular blood flow resistance secondary to impaired red cell deformability could be a common underlying mechanism.…”

Section: Discussionmentioning

confidence: 88%

Red blood cell distribution width and myocardial scar burden in coronary artery disease

Magri¹,

Tian

Camilleri

et al. 2017

Postgraduate Medical Journal

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Section: Discussionmentioning

confidence: 88%

Red blood cell distribution width and myocardial scar burden in coronary artery disease

Magri¹,

Tian

Camilleri

et al. 2017

Postgraduate Medical Journal

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“…Moreover, Gül et al (22) reported that high RDW has a predictive value for reinfarction, hospitalization due to HF, and mortality during long-term follow-up of patients with NST-ACS. Similarly, Tanboğa et al (23) demonstrated that high RDW was an independent predictor of impaired coronary collateral circulation in patients with NSTEMI.…”

Section: Discussionmentioning

confidence: 89%

Relationship between red cell distribution width and long-term mortality in patients with non-ST elevation acute coronary syndrome

Bekler

Tenekecioğlu

Erbağ³

et al. 2015

Anatol J Cardiol

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Objective:Red cell distribution width (RDW) has been reported to be a predictor of cardiac events in coronary artery disease (CAD). Here, we hypothesized that RDW level on admission would be predictive of adverse outcomes in non-ST elevation acute coronary syndrome (NST-ACS).Methods:In total, 202 patients with NST-ACS (159 males and 43 females) were retrospectively analyzed. The patients were divided into two groups based on the 50th percentile of admission RDW levels. A high RDW group (n=100) was defined as those patients having RDW levels of >14.0. The relationship between RDW and primary endpoint (cardiovascular death), secondary endpoints [(reinfarction, repeat target vessel revascularization-percutaneous/surgical)], and major adverse cardiac events (MACE) were assessed. The median follow-up time was 18 (13-24) months.Results:The patients in the high RDW group were older (62.9 vs. 57.5, p=0.001). Multivessel disease, low-density lipoprotein, creatinine, platelet, CK-MB, troponin I, and RDW were higher (p=0.047, p=0.003, p=0.012, p=0.012, p=0.017, p<0.001, respectively), and gender (male/female), ejection fraction, and hemoglobin levels were lower (p=0.021, p=0.04, p=0.016, respectively) in the high RDW group. Cardiovascular death and MACE were higher in the high RDW group (16% vs. 4.9%, p=0.01, 52% vs. 31.4%, p=0.003, respectively). By multiple regression analysis in 202 patients, age >65 and RDW >14.0% on admission were found to be powerful independent predictors of cardiovascular mortality (OR: 4.5, 95% CI: 1.5-13.1, p=0.005, OR: 3.0, 95% CI: 1.0-8.9, p=0.039, respectively).Conclusion:A high RDW level on admission is associated with increased long-term mortality in patients with NST-ACS.

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“…Emerging evidence suggests a role for RDW as a marker for poor outcome in many disease and clinical states such as in patients undergoing percutaneous coronary intervention and coronary artery bypass surgery, acute coronary syndromes, heart failure, systemic hypertension, atrial fibrillation, cardiac resynchronization therapy, and stroke; the higher the RDW, the worse the prognosis [7][8][9][10][11][12][13][14][15][16].…”

Section: Discussionmentioning

confidence: 99%

Increased level of red blood cell distribution width is associated with deep venous thrombosis

Çay¹,

Ünal²,

Kartal³

et al. 2013

Blood Coagulation &Amp; Fibrinolysis

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Previous studies have demonstrated a significant association between red blood cell distribution width (RDW) and acute pulmonary embolism. To the authors' knowledge no study has been reported in patients with deep venous thrombosis (DVT). A total of 431 lower extremity venous duplex examinations were included in the study. Of these, 216 examinations with the diagnosis of DVT were compared to 215 examinations with normal duplex findings with respect to RDW. The two groups were well matched. DVT group had a higher median value and the interquartile range (25th and 75th) of RDW (%) level [14.9 (14.2-16.7)] compared to control group [14.4 (13.6-15.2); P < 0.001], respectively. Patients were divided into tertiles based on RDW. DVT was detected in 42 patients (31.6%) in the lowest tertile, in 81 (53.3%) in the middle tertile, and in 93 (63.7%) in the highest tertile (P < 0.001). In multivariate analysis after adjustment for confounding variables, RDW was the only parameter to predict the presence of DVT [odds ratio (OR) 1.37; 95% confidence interval (CI) 1.21-1.55; P < 0.001]. After removing patients with chronic DVT, the interquartile range (25th and 75th) of the RDW (%) level was also higher in the DVT group [15.0 (14.2-16.7)] compared with the control group [14.4 (13.6-15.2); P < 0.001], respectively. In addition, in proximal DVT, the significant difference continued to be present, although this significance was lost in distal DVT [14.4% (13.6-15.2) vs. 16.1% (15.1-17.4), P < 0.001 and 14.4% (13.6-15.2) vs. 14.3% (14.2-14.7), P = 0.959]. In multivariate analysis, RDW was an independent predictor of risk of proximal DVT (OR 1.60; 95% CI 1.39-1.84; P < 0.001). RDW (%) level was significantly higher in patients with bilateral DVT than in patients with unilateral DVT [16.0 (14.8-17.1) vs. 14.4 (14.2-14.8), P < 0.001, respectively]. In receiver operating characteristics curve analysis, RDW more than 14.9% had 85% sensitivity and 73% specificity in predicting proximal DVT. RDW, an inexpensive and easily measurable laboratory variable, was independently and significantly associated with the presence and severity of DVT, especially nonchronic proximal DVT. The mechanism of association requires, however, further study.

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Relation of Coronary Collateral Circulation With Red Cell Distribution Width in Patients With Non-ST Elevation Myocardial Infarction

Abstract: Our study results demonstrated that, high RDW, high CK-MB, and absence of preinfarction angina were found to be independent predictors of impaired CCC.

Cited by 15 publications

References 25 publications

Red blood cell distribution width and myocardial scar burden in coronary artery disease

Red blood cell distribution width and myocardial scar burden in coronary artery disease

Relationship between red cell distribution width and long-term mortality in patients with non-ST elevation acute coronary syndrome

Increased level of red blood cell distribution width is associated with deep venous thrombosis

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