Relation of diabetes to coronary artery ectasia: A meta-analysis study

Abstract

Relation of diabetes to coronary artery ectasia: A meta-analysis study ABSTRACT Objective: Previous studies have shown a significant negative association between diabetes and abdominal aortic aneurysm. However, the relation of diabetes to coronary artery ectasia (CAE) has not well established. The aim of the current study was to conduct a systemic review for evaluating the relationship between diabetes and CAE. Methods: A systemic search of electronic databases (PUBMED, EMBASE, OVID, WEB OF SCIENCE, THE COCHRANCE LIBRARY) from 1970 to March 2013 was performed. Additionally, checking reference lists from identified articles, reviews, and the abstracts presented at related scientific meetings were also carried out. All case-control studies investigating appropriate prevalence data were included. Results: Among 328 articles, 10 case-control studies were finally identified. The prevalence of diabetes in studied patients with CAE was 8% to 33%, while in those without CAE was ranged from 13.5% to 35%. Pooled analysis showed a reduced rate of diabetes amongst patients with CAE compared to those without (OR 0.65, p<0.0001). Conclusion: Our findings suggested that diabetes might play a protective role for the development of CAE, indicating that further study is needed to evaluate the association diabetes and CAE including underlying mechanisms and future medical interventional strategies.

Monocyte Chemoattractant Protein-1 Is an Independent Predictor of Coronary Artery Ectasia in Patients with Acute Coronary Syndrome

“…Other findings in our study were in accordance with previous publications, where male gender and history of dyslipidemia, but not diabetes, were found to be independent clinical predictors of CAE [38,39]. Similarly, the right coronary artery was the vessel most frequently affected by CAE [5].…”

Epidemiology and risk factors of coronary artery aneurysm in Taiwan: a population based case control study

“…It is noteworthy that an inverse association between diabetes and the presence of CAA had been reported in several studies. 19 20 22 A previous meta-analysis 37 indicated diabetes as a protective factor for the occurrence of CAA, with a pooled OR of 0.65 (95% CI 0.54 to 0.77). For a positive association, it was reported that hyperglycaemia can trigger arterial inflammation and increase the risk of atherosclerosis, 36 which is a risk factor for CAA.…”

“…Nonetheless, a debate on whether CAA is a variant of atherosclerosis still exists. 38 Conversely, some authors proposed that the protective effect of diabetes may be from negative arterial remodelling 39 and increased matrix volume 37 of the coronary arteries. As a whole, the association between diabetes and CAA is currently not well defined.…”

The Presence of Fragmented QRS on 12-Lead Electrocardiography in Patients with Coronary Artery Ectasia

“…Some inflammatory markers such as C-reactive protein, interleukin 6, tumor necrosis factor a, matrix metalloproteinase, hypertension and smoking have been reported to be associated with CAE 15)16)17)18). However, some atherosclerotic risk factors such as advanced age and diabetes have been reproted to be inversely associated with CAE 18)19). CAE is reported in 1.5% to 5% of patients used in coronary angiographic studies 20).…”

“…Angina pectoris can be seen in patients with CAE without CAD. In addition, some studies14)15)16)17)18)19)20)21) have shown that the frequency of acute coronary events via vasospasm, dissection, or thrombus is higher in patients with isolated CAE than in patients with normal coronary angiograms. Moreover, it has been reported that 29% to 39% of patients with isolated ectasia have a history of previous MI or angina pectoris and that patients with CAE have an increased risk of mortality equivalent to patients with CAD 21)…”