Relation of erythrocyte and iron indices to oral cancer growth

Bhattathiri, V.N.

doi:10.1016/s0167-8140(01)00326-7

Cited by 19 publications

(27 citation statements)

References 37 publications

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“…A high majority of cases had normal MCV in both SCC and EPL group (79% vs 84% respectively). The MCHC level was less than normal in 93.6% cases of SCC as compared to 70.7% reported by Bhattathiri et al 25 The difference of MCHC in the three groups was found to be extremely significant suggesting iron deficiency as a prominent cause of anaemia in our study population. However, this fact is not unexpected as HNSCC cases are prone to poor nutrition because of difficulties in food intake, swallowing and absorption from tumor-related mechanisms in addition to tumor-induced metabolic abnormalities.…”

Section: Red Cell Distribution Width (Rdw)contrasting

confidence: 63%

“…Bhattathiri VN also reported that most of the patients were anaemic in terms of Hb (63%), RBC (43%) and HCT (48.4%). 25 This shows that anaemia is associated more with SCC than normal population (33.3%, 23.3% and 53.3% respectively). Claudia Cordella reported 18.5% cases as mild anemia and 10.1% in the severe anemia group and showed association of low Hb levels with the lymph node metastasis (p=0.005), but not the initial T status (p=0.183).…”

Section: Erythrocyte Countmentioning

confidence: 83%

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Evaluation of Hematological Parameters as a Possible Marker for Head - And - Neck Cancer and Precancerous Conditions

Bhattacharjee¹,

Borah²,

Giri³

et al. 2015

jemds

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BACKGROUNDHead neck cancer (HNCA) is a major health problem, accounting for 30-40% cancers at all sites with the incidence in North-East India, where this study has been conducted is highest in the country (54.48%). As various substances alter quantitatively in the serum during tumor development, we intended to explore the changes in the haematological profile in cases of head neck squamous cell carcinoma and epithelial precursor lesions. Moreover, such study will be the first on HNCA patients in this North East region of India.

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Section: Red Cell Distribution Width (Rdw)contrasting

confidence: 63%

Section: Erythrocyte Countmentioning

confidence: 83%

Evaluation of Hematological Parameters as a Possible Marker for Head - And - Neck Cancer and Precancerous Conditions

Bhattacharjee¹,

Borah²,

Giri³

et al. 2015

jemds

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“…Whilst several studies have reported positive associations between MCHC and oral squamous cell carcinoma [80] or head and neck cancers [81], others found no statistically significant associations [82, 83]. …”

Section: Discussionmentioning

confidence: 99%

A prospective cohort examination of haematological parameters in relation to cancer death and incidence: the Busselton Health Study

et al. 2018

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BackgroundCancer risk is associated with serum iron levels. The aim of this study was to evaluate whether haematological parameters reflect serum iron levels and may also be associated with cancer risk.MethodsWe studied 1564 men and 1769 women who were enrolled in the Busselton Health Study, Western Australia. Haematological parameters evaluated included haemoglobin (Hb), mean cell volume (MCV), mean cell haemoglobin (MCH) and mean cell haemoglobin concentration (MCHC) and red cell distribution width (RCDW). Statistical analyses included t-tests for quantitative variables, chi-square tests for categorical variables and Cox proportional hazards regression modelling for cancer incidence and death.ResultsThere was marginal evidence of an association between MCV (as a continuous variable) and non-skin cancer incidence in women (HR 1.15, 95% CI 1.013, 1.302; p = 0.030) but the hazard ratio was attenuated to non-significance after adjustment for serum ferritin (SF), iron and transferrin saturation (TS) (HR 1.11, 95% CI 0.972, 1.264; p = 0.126). There was strong evidence of an association between MCHC and prostate cancer incidence in men; the estimated hazard ratio for an increase of one SD (0.5) in MCHC was 1.27 (95% CI 1.064, 1.507; p = 0.008). These results remained significant after further adjustment for SF and iron; the estimated hazard ratio for an increase of one SD (0.5) in MCHC was 1.25 (p = 0.014, 95% CI 1.05 to 1.48).ConclusionsThe MCHC and MCV were associated with cancer incidence in a Western Australian population, although only MCHC remained associated with prostate cancer after adjusting with serum iron and TS (circulating iron) and SF (storage iron). Haematological parameters are thus of limited utility in population profiling for future cancer risk.

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“…In patients with anal carcinoma, an increased iron concentration was found, whereas in patients suffering from cancer of the larynx, the iron content was lower, in comparison with the control samples. In patients with oral cavity cancer, it was found that the iron content in the serum does not differ from biochemical standards [35, 36]. In the case of studies carried out on humans, different dietary habits, medicines, or food supplements can significantly affect the level of mineral components in the blood, irrespectively of the existing disease (at least at the beginning of the disease).…”

Section: Discussionmentioning

confidence: 99%

Copper and Resveratrol Attenuates Serum Catalase, Glutathione Peroxidase, and Element Values in Rats with DMBA-Induced Mammary Carcinogenesis

Skrajnowska

Bobrowska-Korczak

Tokarz

et al. 2013

Biol Trace Elem Res

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In this paper, a hypothesis was assessed whether or not the intoxication with copper and supplementation with copper plus resveratrol would result in changes in the activities of catalase and glutathione peroxidase and moreover if the characteristic changes would appear in concentrations of copper, iron, calcium, magnesium, and zinc in the serum of rats with chemically induced carcinogenesis. Female Sprague-Dawley rats were divided into study groups which, apart from the standard diet, were treated with copper (42.6 mg Cu/kg food as CuSO4·5H2O) or copper plus resveratrol (0.2 mg/kg body) via gavage for a period from 40 days until 20 weeks of age. In cancer groups, the rats were treated with a dose of 80 mg/body weight of 7,12-dimethyl-1,2-benz[a]anthracene (DMBA) given in rapeseed oil at 50 and 80 days of age to induce mammary carcinogenesis. The control groups included the rats kept in the same conditions and fed with the same diet as the animals from the study groups, but not DMBA-treated. The activity of catalase significantly decreased in groups of rats with mammary carcinogenesis that were supplemented with copper (p < 0.05) or copper plus resveratrol (p < 0.001) in comparison with the control groups that received the same diets. In cancer groups of nonsupplemented rats, the increase of glutathione peroxidase activity was observed. The process of carcinogenesis and the applied supplementation significantly altered the concentrations of trace elements in serum, in particular as concerns iron and copper. The mean serum iron levels in rats with breast cancer were significantly lower than those in the control groups (p < 0.001). The mean serum copper levels significantly decreased in the groups of rats with mammary carcinogenesis that were supplemented with copper or copper plus resveratrol in comparison with the control groups that received the same diets (p < 0.001). The characteristic changes in iron content and the zinc/copper and zinc/iron ratios in blood may be used as one of the prognostic factors in breast cancer research.

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Relation of erythrocyte and iron indices to oral cancer growth

Cited by 19 publications

References 37 publications

Evaluation of Hematological Parameters as a Possible Marker for Head - And - Neck Cancer and Precancerous Conditions

Evaluation of Hematological Parameters as a Possible Marker for Head - And - Neck Cancer and Precancerous Conditions

A prospective cohort examination of haematological parameters in relation to cancer death and incidence: the Busselton Health Study

Copper and Resveratrol Attenuates Serum Catalase, Glutathione Peroxidase, and Element Values in Rats with DMBA-Induced Mammary Carcinogenesis

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