Relation of Haemoglobin Levels in First and Second Trimesters to Outcome of Pregnancy

Murphy, John F.; Newcombe, Robert G.; O’Riordan, Joan; Coles, E C; Pearson, James F.

doi:10.1016/s0140-6736(86)91269-9

Cited by 445 publications

(350 citation statements)

References 22 publications

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“…The prevalence of anemia in our study was similar to previous reports conducted in Korea (Lim and Kim, 1998;Yu et al, 1999) and in Asia (Hui et al, 1995). Anemia or iron deficiency during pregnancy is associated with intrauterine growth retardation, premature birth, low birth weight, increased labor time, higher risk of infection, elevated maternal and prenatal mortality, muscle dysfunction and low physical capacity (Murphy et al, 1986;Lu et al, 1991;Scholl and Hediger, 1994;Singh et al, 1998;Zhou et al, 1998;Yip, 2000). Lone et al (2004) reported the association between low maternal Hb level and Apgar score o5 at 1 min, which is an index of health status of newborn babies.…”

Section: Discussionmentioning

confidence: 99%

Iron status and its association with pregnancy outcome in Korean pregnant women

Lee¹,

Kim

et al. 2006

Eur J Clin Nutr

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Objective: The purpose of this study was to assess the prevalence of iron deficiency anemia among Korean pregnant women and to assess the association between maternal hemoglobin (Hb) level and pregnancy outcome. Design: A longitudinal study. Setting: Ewha Womans University Hospital, Seoul, Korea. Subjects: A total of 248 normal pregnant women of 24-28 weeks gestation and 190 babies born to the pregnant subjects. Methods: Maternal anthropometry, blood parameters and pregnancy outcomes were measured. Results: Mean Hb, serum iron concentration, transferrin saturation and total iron binding capacity of the subjects were 11.4 g/dl, 89.4 mg/dl, 18.7% and 484.6 mg/dl, respectively, and 30.2% of the subjects were anemic judged by Hb concentration of o10.5g/dl. When subjects were classified into tertile groups based on Hb levels, the lowest tertile (HbT1) group had significantly lower concentrations of cord serum iron and albumin than those in the highest tertile (HbT3) group. Newborn infants from the HbT1 group had significantly higher rates of preterm delivery, low birth weight and low Apgar scores than those in other groups. Logistic regression analysis showed that maternal serum albumin and Hb level were the most important predictive variables for low birth weight. Conclusions: A substantial proportion of Korean pregnant women were at risk of anemia. Infants born to women with a low Hb level showed a lower birth weight, height and Apgar scores.

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Section: Discussionmentioning

confidence: 99%

Iron status and its association with pregnancy outcome in Korean pregnant women

Lee¹,

Kim

et al. 2006

Eur J Clin Nutr

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“…[13] After controlling for many other variables in a large Californian study, Klebanoff et al [14] showed a doubled risk of preterm delivery with anaemia during the second trimester but not during the third trimester. [14] …”

Section: Preterm Deliverymentioning

confidence: 99%

Study of Maternal and Perinatal outcome in moderate to severe degree iron deficiency anaemia in rural community

Bangal¹,

Aher²,

Bhosale³

et al. 2016

Int J of Biomed & Adv Res

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Background: Anaemia is the commonest medical disorder associated with pregnancy. It contributes to one fifth of the maternal deaths and large number of preterm deliveries and low birth weight babies in India. Objectives: To study maternal and perinatal outcome in pregnancies complicated by anaemia. Setting-Tertiary care teaching hospital in central India. Study Design: Prospective observational study. Material and Methods: Study was conducted for a period of two years from September 2012 to August 2014. A total of 1644 pregnant women were screened for evidence of iron deficiency anaemia. Maternal and perinatal outcome of women with moderate to severe anaemia was analyzed. Statistical analysis: was done by finding out percentages, proportions, Mean and Standard deviation (SD), Chi square test. Results: Prevalence of anaemia among pregnant women was 49.40%. Mild, moderate and severe degree of anaemia was seen in 19.46%, 25.06% and 04.86% cases respectively. The incidence of preterm delivery and low birth weight babies was two times more than women with normal haemoglobin values. The perinatal mortality and morbidity among babies born to anaemic women was high. There was no maternal mortality in the present study. Conclusion:The study revealed that anaemic women are more prone for life threatening obstetric and medical complications, preterm labour, low birth weight babies and perinatal morbidity and mortality., Strengthening the peripheral health care delivery system, regular antenatal care, high risk pregnancy identification, oral and parenteral iron therapy and institutional deliveries can reduce the incidence of anaemia and the resultant morbidity and mortality.

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“…Existe una asociación entre el hematocrito/hemoglobina materna, parto prematuro (<37 semanas de gestación), bajo peso de nacimiento (<2.500g) y morbi-mortalidad perinatal [23][24][25][26][27][28][29][30] . Hay evidencias que la asociación entre hemoglobina baja y parto prematuro se da sólo en los dos primeros trimestres de gestación 24,[27][28][29][30] . Por otra parte existe una relación entre la severidad de la anemia y el curso del embarazo.…”

Section: Consecuencias De La Deficiencia De Hierro En El Embarazounclassified

Causas y consecuencias de la deficiencia de hierro

Olivares

Walter

2004

Rev. Nutr.

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La deficiencia de hierro es la deficiencia nutricional más prevalente y la principal causa de anemia a escala mundial. Además de las manifestaciones propias de la anemia, se han descrito otras manifestaciones no hematológicas tales como: disminución de la capacidad de trabajo físico y de la actividad motora espontánea, alteraciones de la inmunidad celular y de la capacidad bactericida de los neutrófilos, disminución de la termogénesis, alteraciones funcionales e histológicas del tubo digestivo, falla en la movilización de la vitamina A hepática, mayor riesgo de parto prematuro, bajo peso de nacimiento y de morbilidad perinatal, menor transferencia de hierro al feto, una disminución de la velocidad de crecimiento, alteraciones conductuales y del desarrollo mental y motor, velocidad de conducción más lenta de los sistemas sensoriales auditivo y visual, y reducción del tono vagal. La prevención de la deficiencia de hierro incluye cambios en los hábitos alimentarios, fortificación de los alimentos y la suplementación con hierro.

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Relation of Haemoglobin Levels in First and Second Trimesters to Outcome of Pregnancy

Cited by 445 publications

References 22 publications

Iron status and its association with pregnancy outcome in Korean pregnant women

Iron status and its association with pregnancy outcome in Korean pregnant women

Study of Maternal and Perinatal outcome in moderate to severe degree iron deficiency anaemia in rural community

Causas y consecuencias de la deficiencia de hierro

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