Relation of hemoglobin A1c to rate of major adverse cardiac events in nondiabetic patients undergoing percutaneous coronary revascularization

Glycosylated hemoglobin levels and outcome in non-diabetic cardiac surgery patients

“…35 The difference between our findings and those of Halkos et al with regard to sternal wound infection may involve the lack of diabetics in our study sample, but it may also be related to our smaller sample size and/or the low rate of sternal wound infection in our study. The rate of Hb1Ac elevation seen in our study (31%) and a cohort of non-diabetic patients undergoing percutaneous coronary interventions (30%) 19 are lower than in two other studies of vascular (57%) and cardiac (58%) surgery patients. 18,20 A possible explanation for this discrepancy may be the potential for elevated HbA1c to be associated with risk for emergent surgery, procedures which were not included in the first two studies.…”

“…17,18 Thirty percent of non-diabetics undergoing percutaneous coronary interventions have elevated HbA1c levels, and these patients are at higher risk of cardiac mortality and adverse events. 19 Complication rates are also higher in nondiabetic vascular surgery patients with elevated HbA1c. 18 While elevated HbA1c levels are also common in non-diabetic cardiac surgery patients (57% in one study), 20 the relationship between HbA1c and perioperative mortality risk is not well understood.…”

Association of Glycemic Control With Mortality in Patients With Diabetes Mellitus Undergoing Percutaneous Coronary Intervention

“…Incidence of major adverse cardiovascular event at 1 year was similar between groups (23.7% versus 20.8%; P=0.45). In yet another smaller study, which had a prospective design, Corpus et al 14 studied the relationship between glycemic control on target vessel revascularization after elective PCI. Patients with HbA1c >7% (mean, 8.8±1.6) had higher rate of target vessel revascularization (34% versus 15%; P=0.03) as compared with patients with HbA1c ≤7% (mean, 6.5±0.5).…”

Haemoglobin A1c levels and subsequent cardiovascular disease in persons without diabetes: a meta-analysis of prospective cohorts

“…After reading the full text, there were 26 potentially acceptable studies that were rejected at the final stage: 14 did not have appropriate data [1,[13][14][15][16][17][18][19][20][21][22][23][24][25]; four did not involve outcomes of interest [26][27][28][29]; three studied non-relevant populations [30][31][32]; three were duplicates [33][34][35]; and two were editorials/review papers [36,37]. That left seven papers for analysis [38][39][40][41][42][43][44]. Figure 1 depicts the results of the literature search and disposition of the identified articles.…”

“…2. Five articles reported cardiovascular deaths as a primary outcome [39][40][41][42]44] in seven sets of outcome data, and two studies [42,44] examined men and women separately. There were 1,366 cardiovascular deaths (3.1% of all persons assessed), or 3.37/1,000 person-years of followup.…”