“…Within broad limits, it was impossible to tell the degree of liver competence by the histological picture. Similar difficulties with biopsy material are reported by Cates (46). In 2 patients who showed partial improvement for over 2 years, and who then died (Cases 28 and 29), there was marked necrosis of liver cells and periportal fibrosis similar in degree to the cirrhosis of patients who died after a rapid failure of several weeks.…”