Summary. The comparison of two groups of patients with different anastomosis techniques (346 large bowel resections) demonstrates a lower degree of complications and mortality rates with the single layer anastomosis. These observations were proven in dogs. The double layer sutures had a prolonged healing process, a delayed revascularisation, intramural abscess formation and a stenotic intraluminal roll building. These problems were not observed in single layer anastomosis, rather than a faster healing process. Angiographically the capillary infiltration already during the first postoperative week was seen.

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In 30 rats the healing process of colonic anastomosis contaminated with Staphylococcus aureus was studied. At the same time on each animals a single- and double-layer anastomosis was performed. All sutures were infected during the surgical procedure with highly infectious S. aureus. The rats were sacrificed after 1, 2, 3, 4 days, and 2 1/2 weeks. Criteria for estimation were mainly visible abscess formations, leakage spots, bacteriologic and histologic examinations. After apparent inflammatory reactions were seen on the first postoperative days with a maximum on the 4th day, all sutures were completely healed and free of S. aureus after 2 1/2 weeks. As for the extent of infectious inflammation, the single-layer suture technique proved to be more resistant than the double layer.

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