Relation of Ocular Sensitivity to the Arthus Phenomenon in the Rabbit

Burky, Earl L.

doi:10.1001/archopht.1933.00830040084007

Cited by 7 publications

(1 citation statement)

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“…where coarse hair rapidly regrew, for Burky (3) has shown that skin bearing such a coat reacts differently to staphylotoxin than does that remaining hairless long after depilation. The accessory substance used to induce reactions was staphylotoxin, made by growing Staphylococcus aureus, strain Ha, 1 for 10 days in beef heart infusion broth containing 1 per cent neopeptone and 0.5 per cent NaCI, reaction pH 7.8; to this 0.2 per cent dextrose was added several days before inoculation.…”

Section: E X P E R I M E N T a Lmentioning

confidence: 99%

Studies in Synergy

Swift

Schultz

1936

Journal of Experimental Medicine

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The following experiments were stimulated by our interest in the subject of "allergic irritability" (1) and in the work of Burky (2) who observed that weakly antigenic substances, for example, beef lens and ragweed pollen, provoked in rabbits marked antibody formation and hypersensitiveness when combined with staphylotoxin produced by growing staphylococci in broth containing the weak antigen. He hypothesized that this was due to the conjugation, in vitro, of the poor antigen with the powerful antigenic toxin. Of particular interest was the marked sensitivity of rabbits to simple mechanical trauma after several injections of rabbit muscle toxin. Because we had observed comparable phenomena in rabbits treated in other ways we felt t h a t the hyperreactivity might be due to factors arising in the animal's body rather than to those occurring simply in vitro. The present communication deals with tests of this hypothesis. E X P E R I M E N T A LThe experiments, in general, were arranged to permit comparison of groups of animals injected in different ways with the two antigenic substances.The rabbits were adults, of either an English-lilac-Havana hybrid stock, or pure Havanas, strains usually quite resistant to spontaneous infection. In any given experiment a single variety was employed, and usually animals were of the same sex. Only those with large areas of good skin were selected; the hair was removed with a fine mechanical clipper; and care was taken not to inject sites

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Section: E X P E R I M E N T a Lmentioning

confidence: 99%