Induction of Ocular Inflammation by Synthetic Mediators

Treatment of Vitreous Hemorrhage in Rh-Positive Patients by Intravitreal Injection of Anti-Rh0- Immunoglobulin

“…Nevertheless, the consequent increase in levels of the activated comple ment component C5a might account for the transient inflammatory reaction seen in the vitreous bodies of some patients after im munoglobulin injection. A similar response has been documented after the injection of this component in rabbits [6]. It should also be emphasized that a process like antibodydependant cellular cytotoxicity (ADCC) of lymphocytes directed against Rh-positive red blood cells and natural-killer cells could be responsible for the observed phenome non of erythrocyte cleavage [7].…”

Phospholipase A2Activity in Normal andStaphylococcus aureus-Infected Rabbit Eyes

“…Inflammation that is characteristic of keratitis in the rabbit model includes chemosis, injection, and accumulation of pus on the corneal surface. 34,46 Soluble bacterial products, such as toxins, 47 mediate tissue damage and induce host chemotactic agents, such as complement and cytokines, that are known mediators of ocular inflammation. 47,48 In addition, inflammation may be due in part to the release of arachidonic acid after digestion of the bacterial inoculum by PLA 2 .…”

Breakdown of the Blood-Ocular Barrier as a Strategy for the Systemic Use of Nanosystems

“…Interestingly, ocular inflammation has also been experimentally induced through the use of synthetic mediators. The complement component C5a, N -formylmethionyl-leucyl-phenylananine (FMLP) and chemotactic mediators were injected into the rabbit cornea, vitreous, and skin in order to induce a reaction resembling the “Arthus phenomenon” [ 114 ]. Miyake et al .…”