Relation of plasma lipids to all-cause mortality in Caucasian, African-American and Hispanic elders

Akerblom, Jennifer L.; Costa, Rosann; Luchsinger, José A.; Manly, Jennifer J.; Tang, Mingxin; Lee, Joseph H.; Mayeux, Richard; Schupf, Nicole

doi:10.1093/ageing/afn017

Cited by 40 publications

(40 citation statements)

References 31 publications

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“…In the present study, high FBS was significantly associated with all-cause, CVD, and expanded CVD mortality, whereas high SBP and TG were not. Most interestingly, high TC was negatively associated with mortality, which has been reported previously [30], [31]. In the present study, high TC was associated with higher BMI.…”

Section: Discussionsupporting

confidence: 86%

Association of Body Mass Index with All-Cause and Cardiovascular Disease Mortality in the Elderly

Chou

Huang

et al. 2014

PLoS ONE

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ObjectivesTo evaluate the associations of body mass index (BMI) with all-cause, cardiovascular disease (CVD), and expanded CVD mortality in the elderly.DesignObservational cohort study.SettingAnnual physical examination program for the elderly from 2006 to 2010.ParticipantsWe included 77,541 Taipei residents aged ≥65 years (39,365 men and 38,176 women).MeasurementsBMI was categorized as underweight (BMI<18.5), normal weight (18.5≤BMI<25), overweight (25≤BMI<30), grade 1 obesity (30≤BMI<35), or grade 2–3 obesity (BMI≥35). Mortality was ascertained by national death files.ResultsUnderweight (hazard ratios [HRs] of all-cause, CVD, and expanded CVD mortality: 1.92, 1.74, and 1.77, respectively), grade 2–3 obesity (HRs: 1.59, 2.36, and 2.22, respectively), older age, male sex, smoking, and high fasting blood sugar were significant predictors of mortality. Meanwhile, being married/cohabitating, higher education, alcohol consumption, more regular exercise, and high total cholesterol were inversely associated with mortality. Multivariate stratified subgroup analyses verified smokers (HRs of all-cause, CVD, and expanded CVD mortality: 3.25, 10.71, and 7.86, respectively, for grade 2–3 obesity), the high triglyceride group (HRs: 5.82, 10.99, and 14.22, respectively for underweight), and patients with 3–4 factors related to metabolic syndrome (HRs: 4.86, 12.72, and 11.42, respectively, for underweight) were associated with mortality.ConclusionThe associations of BMI with all-cause, CVD, expanded CVD mortality in the elderly are represented by U-shaped curves, suggesting unilateral promotions or interventions in weight reduction in the elderly may be inappropriate. Heterogeneous effects of grades 1 and 2–3 obesity on mortality were observed and should be treated as different levels of obesity.

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Section: Discussionsupporting

confidence: 86%

Association of Body Mass Index with All-Cause and Cardiovascular Disease Mortality in the Elderly

Chou

Huang

et al. 2014

PLoS ONE

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“…This is particularly evident in male Hispanics with diabetes [49]. Furthermore, the inverse relationship between total cholesterol, non-HDL cholesterol, and lowdensity lipoprotein cholesterol and all cause mortality may not hold for Hispanics as it does for blacks and Caucasians [50] The reason(s) for these findings are unclear, but may be due to competing mortality from other causes and/or other factors that interact with diabetes [49,50].…”

Section: Hispanicsmentioning

confidence: 99%

The economic consequences of diabetes and cardiovascular disease in the United States

Ariza

Vimalananda

Rosenzweig

2010

Rev Endocr Metab Disord

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Diabetes-related care and complications constitute a significant proportion of the United States' (US) health care expenditure. Of these complications, cardiovascular disease (CVD) is a major component. Higher morbidity and mortality rates translate to higher costs of care in patients with diabetes compared to those who do not have the disease. Minorities bear a disproportionate burden of diabetes and CVD. We review this disparity and examine potential etiologies for it in Hispanics and African-Americans, the two largest minority groups in the US. We examine strategies in these populations that may improve outcomes in diabetes and CVD, potentially decreasing health care costs.

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“…Beyond the complexities of identifying dementia syndromes in general, the incidence rate of probable cognitive impairment in this sample was relatively low (Akerblom et al 2008). This makes it difficult to evaluate finely detailed pattern differences.…”

Section: Limitationsmentioning

confidence: 88%

“…Residents of the target zone from which this population was derived represent three broadly defined racial/ ethnic groups; that is, non-Latino African-American, Caribbean Latino (primarily Dominican Republic), and non-Latino Whites of European decent (Akerblom et al 2008). Sample construction and recruitment has been comprehensively described by Tang et al (2001).…”

Section: Population and Samplementioning

confidence: 99%

Gender differences in affective suffering among racial/ethnically diverse, community-dwelling elders

Yancu

2011

Ethnicity & Health

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Objective. Copious research shows a female excess of unipolar depression. The generalizability of this finding is examined in a racial/ethnically diverse, community-residing, elder sample. Design. Depressive suffering was assessed both categorically and linearly with the Index of Affective Suffering (IAS), a hierarchal measure designed to examine intensity and extensity of suffering. In-home interviews by specially trained raters also collected demographic, functional, and social health data. Prevalence rates of affective suffering were examined separately for Latinos (N=996, Females=46.8%), Blacks (N=717, Females=36.5%), and Whites (N=415, Females=18.6%). Results. Analyzed by gender alone these data support the typical wisdom that females report significantly more depressed affect than males. However, by racial/ethnic group categorical analysis indicates that among Whites and Latinos, women reported more symptoms of clinically significant affective suffering than males; whereas, among Blacks, women and men did not differ from each other. Moreover, risk factors commonly associated with excess female depression failed to explain observed differences. Conclusion. The absence of a between-gender difference in affective suffering observed among Black elders in this study raises questions about generalized assumptions of greater 'female' vulnerability for this age group. A need for research to appreciate the heterogeneity of elder individuals is highlighted as is the importance of using dimensional assessment techniques in psychiatric epidemiology.

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Relation of plasma lipids to all-cause mortality in Caucasian, African-American and Hispanic elders

Abstract: hispanic ethnicity modifies the associations between lipid levels and all-cause mortality in the elderly.

Cited by 40 publications

References 31 publications

Association of Body Mass Index with All-Cause and Cardiovascular Disease Mortality in the Elderly

Association of Body Mass Index with All-Cause and Cardiovascular Disease Mortality in the Elderly

The economic consequences of diabetes and cardiovascular disease in the United States

Gender differences in affective suffering among racial/ethnically diverse, community-dwelling elders

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