Relationship among Oxidative DNA Damage, Gastric Mucosal Density and the Relevance of cagA, vacA and iceA Genotypes of Helicobacter pylori

Ladeira, Marcelo Sady Plácido; Bueno, Roberta C. A.; Santos, Bruna Fornazari dos; Pinto, Carla L. S.; Prado, Renato Paschoal; Silveira, Marcela G.; Rodrigues, Maria Aparecida Marchesan; Bartchewsky, Waldemar; Pedrazzoli, José; Ribeiro, Marcelo Lima; Salvadori, Daisy Maria Fávero

doi:10.1007/s10620-007-9850-0

Cited by 26 publications

(18 citation statements)

References 37 publications

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“…Such discrepancies raise the question of the clinical significance of H. pylori detection via PCR. The use of real-time PCR targeting the H. pylori SSA gene did not permit the demonstration of a significant correlation between number of copies and degree of gastritis [33]. Zsikla et al [34] also noted a lack of correlation between H. pylori DNA molecules (urease C gene)/DNA equivalent of 10 5 cells and inflammation score in biopsies of chronic gastritis.…”

Section: H Pylori Density Assessed By Pcr and Grade Of Inflammationmentioning

confidence: 99%

Bacterial Load and Degree of Gastric Mucosal Inflammation in <i>Helicobacter pylori</i> Infection

Varbanova

Malfertheiner²

2011

Dig Dis

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Helicobacter pylori induces an inflammatory immune response in the gastric mucosa. The degree of gastric mucosal inflammation and its topographic distribution are key factors in the diversity of H. pylori-related complications. Here we summarize substantial evidence reported in the literature concerning the impact of H. pylori density on gastric inflammation, the development of severe complications, and its relation to H. pylori suppression therapy. Most studies demonstrate a significant correlation between H. pylori density and the grade of acute and chronic inflammation, taking into account the limitations of each method for density assessment. Overall, high bacterial loads are associated with increased acute mucosal damage and long-term changes in the gastric mucosa. The influence of H. pylori density reduction on the improvement of gastric mucosal changes was observed in studies using ‘clearance’ therapies. Mucosal agents provoke a significant, but not persistent, reduction in gastritis activity. Treatments suppressing the density and virulence of H. pylori could become strategies to prevent H. pylori-associated disease in the future.

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Section: H Pylori Density Assessed By Pcr and Grade Of Inflammationmentioning

confidence: 99%

Bacterial Load and Degree of Gastric Mucosal Inflammation in <i>Helicobacter pylori</i> Infection

Varbanova

Malfertheiner²

2011

Dig Dis

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“…28 Resultados semelhantes foram encontrados por estudos que compararam os níveis de dano oxidativo ao DNA em portadores de gastrite e neoplasia gástrica associada ou não à presença da Helicobacter pylori. 40 Ao analisar-se a intensidade do dano oxidativo segundo o estadiamento TNM e a classificação original de Dukes, verificou-se que os doentes pertencentes aos estádios precoces das classificações apresentavam valores médios mais elevados que os classificados em estádios mais avançados. É possível que tumores menos avançados em virtude do menor número de mutações em genes relacionados à capacidade de adesão celular e angiogênese ainda sejam passíveis de sofrerem ainda agressão oxidativa.…”

Section: Figura 4 -Formação De 8ohdg Pelas Espécies Livres De Oxigêniunclassified

Avaliação do dano oxidativo ao DNA de células normais e neoplásicas da mucosa cólica de doentes com câncer colorretal

Ribeiro

Priolli

Miranda

et al. 2007

Rev bras. colo-proctol.

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“…27,29 Mukozadaki oksidatif stresin bakteri yoğunluğu ile değil, virulans faktörleriyle iliş-kili olduğu gösterilmiştir. 28 CagA pozitif hastalarda gastritin şiddeti ve aktivasyonunun anlamlı olarak yüksek olduğu, yine bu hastalarda atrofik-metaplastik lezyon prevalansının fazla olduğu tespit edilmiştir. 29 Çalışmamızda oksidatif durum ve antioksidan durum periferik kandan elde edilen serumlarda çalışıldı.…”

Section: Yöntemunclassified

Serum oxidative stress status in CagA positive Helicobacter pylori infection

Asiltürk

Nazlıgül²,

Yıldız³

et al. 2011

J Clin Exp Invest

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Objectives: Previous studies have suggested that CagA positive Helicobacter pylori (H.pylori) infection may cause the various oxidative damages. The objective of this study was to investigate serum oxidative status in infectetion with CagA positive H.pylori strains. Materials and methods:Forty-two H.pylori CagA positive subjects and 39 H.pylori CagA negative subjects were enrolled. H.pylori infection was diagnosed by the histopathological assessment of gastric mucosa. CagA status was detected by enzyme immuno assay in a micro ELISA machine. Total antioxidant status (TAS) and total oxidant status (TOS) were measured autoanalyzer using commercially available kits. Serum oxidative stress index (OSI) was calculated using TAS and TOS measurements. Results:The levels TAS and TOS of CagA positive subjects were found to be 1.48 ± 0.18 mmol/L, 36.88 ± 19.84 mmol/L. Those of CagA negative group were measured to be 1.43 ± 0.19 mmol/L and 38.44 ± 14.72 mmol/L respectively. The values of serum OSI were similar (25.28 ± 15.85 and 26.48 ± 10.02) in CagA positive and negative groups. Conclusions:The measurements of serum oxidative status did not show any sigficant difference between the patients infected with CagA positive and CagA negative H.pilori strains. J Clin Exp Invest 2011;2(2):202-6

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Relationship among Oxidative DNA Damage, Gastric Mucosal Density and the Relevance of cagA, vacA and iceA Genotypes of Helicobacter pylori

Cited by 26 publications

References 37 publications

Bacterial Load and Degree of Gastric Mucosal Inflammation in <i>Helicobacter pylori</i> Infection

Bacterial Load and Degree of Gastric Mucosal Inflammation in <i>Helicobacter pylori</i> Infection

Avaliação do dano oxidativo ao DNA de células normais e neoplásicas da mucosa cólica de doentes com câncer colorretal

Serum oxidative stress status in CagA positive Helicobacter pylori infection

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