Relationship among urinary advanced glycation‐end products, skeletal muscle mass and physical performance in community‐dwelling older adults

Abstract

Aim Advanced glycation end‐products are important factors in muscle function and physical performance among older adults. However, the association between sarcopenia and urinary carboxymethyl‐lysine (uCML) levels remains unclear. The present study aimed to investigate the relationship among uCML levels, skeletal muscle mass, physical performance and sarcopenia among community‐dwelling older adults. Methods This work was a community‐based cross‐sectional study. The participants were recruited from the Taichung Community Health Study‐Elderly and were followed up until 2017. A total of 104 participants underwent dual‐energy X‐ray absorptiometry examination, physical performance tests and measurement of uCML levels. After the natural log transformation of the uCML levels, Pearson's correlation coefficient and a general linear model were used for statistical analysis. Results The mean uCML levels of older men and women were 1.34 μg/mg and 1.63 μg/mg creatinine, respectively. After multivariate adjustment, grip strength among older women significantly decreased as uCML levels increased. Participants with uCML levels and Timed Up and Go test values higher than the median had a 13.76‐fold risk of acquiring sarcopenia compared with those whose corresponding variables were lower than the median after adjusting for age, sex, body fat percentage, and serum creatinine and blood urea nitrogen levels. Conclusions uCML levels were negatively associated with grip strength among older women. The joint association of uCML and Timed Up and Go test values was correlated with the risk of acquiring sarcopenia among older adults. This finding suggests that uCML levels can be used as a biomarker for screening sarcopenia and as a strategy for treating sarcopenia. Geriatr Gerontol Int 2019; 19: 1017–1022.

Ultra-processed food intake is associated with grip strength decline in middle-aged and older adults: a prospective analysis of the TCLSIH study

“…The accumulating evidence has indicated that the production of pro-inflammatory cytokines (e.g., tumor necrosis factor α, interleukin 6, and NF-κB) contributes to the decline in muscle strength [13,14]. Third, AGEs produced during food processing and preparation have been associated with poor muscle strength [15][16][17]. Fourth, UPF intake may increase exposure to chemicals (e.g., phthalates and bisphenols) used in food packaging and production [18].…”

“…Furthermore, food processing and preparation, especially extensive heat treatment (e.g., crackers, chips, cookies, and French fries), leads to the formation of advanced glycation end products (AGEs) [15]. Previous studies indicated that high AGEs were associated with poor muscle strength [16,17]. Moreover, packaging processes may use materials that are in contact with UPFs, such as phthalates and bisphenols [18].…”

Advanced glycation end products in skeletal muscle health and sarcopenia: A systematic review of observational studies

“…The predominant reason for articles being excluded was no relevant outcome measure reported in the studies. Fifteen observational studies (Dalal et al, 2009;Drenth et al, 2018;Ebert et al, 2019;Eguchi et al, 2021;Kato et al, 2017;Kim et al, 2018;Momma et al, 2011;Moriwaki et al, 2021;Tabara et al, 2019;Semba et al, 2010a;Sun et al, 2012;Waqas et al, 2022;Whitson et al, 2014;Wu et al, 2021;Yang et al, 2019) were included in the narrative synthesis (Fig. 1).…”

The Effect of Glycation Stress on Skeletal Muscle

“…In the study, which had a 30-month follow-up in 394 older women (≥ 65 years old), it was shown that compared with the group of lower three quartiles of CML, the patients in the group of highest quartile of CML were more likely to develop severe walking disability (hazard ratio 1.54, 95% confidence interval 1.04-2.29, P = 0.03). A communitybased cross-sectional study by Yang et al [16] showed that urinary CML level was negatively associated with grip strength among 41 older women but not 63 older men (≥ 65 years old). Furthermore, the joint association of urinary CML level and mobility function was correlated with the risk of developing sarcopenia among older adults (odds ratio 13.76, 95% confidence interval 1.03-183.83, P < 0.05).…”

“…Over the last few decades, there has been increasing evidence supporting a profound effect of advanced glycation end products (AGEs) on human diseases, including type 2 diabetes, cardiovascular disease, cancer, Alzheimer's disease, osteoporosis, and dementia, as well as the aging process itself [4,5]. Especially in past decades, many epidemiological studies have suggested the contribution of glycation stress (also called as glycative stress) from AGEs to sarcopenia [6][7][8][9][10][11][12][13][14][15][16][17]. In this chapter, we provide current evidence on the potential role of glycation stress in the impairment of skeletal muscle functions.…”