Relationship between a wide range of alcohol consumptions, components of the insulin-like growth factor system and adiponectin

Maso, Luigino Dal; Vecchia, Carlo La; Augustin, Livia S. A.; Mantzoros, Christos S.; Kendall, Cyril W.C.; Franceschi, Silvia

doi:10.1038/sj.ejcn.1602519

Cited by 13 publications

(6 citation statements)

References 25 publications

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“…However, we found higher SHBG levels among alcohol consumers, whereas their results showed lower SHBG levels [34]. Our findings of borderline significantly higher adiponectin levels in alcohol drinkers than in nondrinkers are supportive of results from cross-sectional [35,36] and intervention studies [37,38]. In our study, IGF-1 levels did not differ by alcohol intake in Asian-American women, but the levels of IGFBP-3 were significantly lower in current consumers.…”

Section: Discussionsupporting

confidence: 83%

“…In our study, IGF-1 levels did not differ by alcohol intake in Asian-American women, but the levels of IGFBP-3 were significantly lower in current consumers. Similarly, most previous studies in postmenopausal women have found little effect of alcohol on IGF-1 levels [36,39,40]. The effect of alcohol intake on IGFBP-3 levels was not consistent in previous studies; no significant changes [40] or significantly lower [36] and higher levels [39] were reported previously.…”

Section: Discussionmentioning

confidence: 65%

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Alcohol and breast cancer risk among Asian-American women in Los Angeles County

Vigen

Razavi

et al. 2012

Breast Cancer Res

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IntroductionThe role of alcohol and breast cancer risk in Asians has not been well studied. Recent studies suggest that even moderate alcohol intake may be associated with an increase in breast cancer risk, and this may be particularly relevant as alcohol intake is traditionally low among Asians.MethodsWe investigated the association between lifetime alcohol intake (including frequency, quantity, duration, timing, and beverage type) and breast cancer in a population-based case-control study of 2,229 Asian Americans diagnosed with incident breast cancer and 2,002 matched control women in Los Angeles County. Additionally, we examined the relation between current alcohol intake and serum concentrations of sex-hormones and growth factors in a subset of postmenopausal control women.ResultsRegular lifetime alcohol intake was significantly higher in US-born than non-US-born Asian Americans (P < 0.001) and almost twice as common in Japanese- than in Chinese- and Filipino-Americans (P < 0.001). Breast cancer risk increased with increasing alcohol intake among US-born Asian Americans; the odds ratios (ORs) per 5 grams per day and per 10 years of drinking were 1.21 (95% confidence interval (CI) 1.00 to 1.45) and 1.12 (95% CI, 0.98 to 1.28), respectively. Regular alcohol intake was a significant risk factor for Japanese-, but not for Chinese- and Filipino-Americans. Current consumers compared with nondrinkers showed lower concentrations of insulin-like growth factor binding protein 3 (P = 0.03) and nonsignificantly higher concentrations of estrone and androgens.ConclusionsRegular lifetime alcohol intake is a significant breast cancer risk factor in US-born Asian Americans and Japanese Americans, emphasizing the importance of this modifiable lifestyle factor in traditionally low-risk populations.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 65%

Alcohol and breast cancer risk among Asian-American women in Los Angeles County

Vigen

Razavi

et al. 2012

Breast Cancer Res

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“…There is evidence linking alcohol by Insulin-like growth factor (IGF) and Insulin-like growth factor binding protein (IGFBP)-3 to mammographic density [32,33]. In addition, alcohol increases estrogen levels in blood [34] which were found to increase mammographic density [35].…”

Section: Discussionmentioning

confidence: 99%

Association of Mediterranean diet, dietary supplements and alcohol consumption with breast density among women in South Germany: a cross-sectional study

et al. 2013

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BackgroundEffects of dietary factors, such as adherence to Mediterranean diet, multivitamin-multimineral supplements use and alcohol consumption on mammographic breast density, an important biomarker of breast cancer risk, are not sufficiently consistent to elaborate preventive recommendations. This study aims to investigate the association between current diet and mammographic density.MethodsWe performed a cross-sectional study in 424 pre- and post-menopausal women aged 21 to 84 years. Current Mediterranean dietary pattern, multivitamin-multimineral supplements use, alcohol consumption and potential confounders were assessed with a self-administered questionnaire in the University Hospital Ulm (2007–2008). Radiologists evaluated mammographic density according to the American College of Radiology (ACR) classification, which was summarized in low = ACR1/2 and high = ACR3/4 mammographic density. Logistic regression models were used to assess the association between current diet and mammographic density.ResultsAdherance to Mediterranean dietary pattern was inversely associated with mammographic density in the models adjusted for age and BMI (per 1 unit increase of score OR 0.95; 95%CI 0.90–0.997). Current use of multivitamin-multimineral supplements was also inversely associated with mammographic density (OR 0.53; 95%CI 0.34–0.83). Further adjustment revealed similar point estimates but the associations were no longer statistically significant. Compared to non-drinkers, excessive alcohol consumption (<10 g/d) was positively associated with mammographic density (OR 1.47; 95%CI 0.82-2.63).ConclusionsOur results show that dietary factors are associated with mammographic density. Adherence to Mediterranean diet and current use of multivitamin-multimineral supplements could be inversely associated with mammographic density and may suggest a protective effect against breast cancer, whereas high alcohol consumption was associated with increased mammographic density.

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“…IGFBP-1 is a physiologic constituent of amniotic fluid and has been implicated in several pathophysiological states including sepsis[49], AIDS[50], excessive alcohol consumption[51], and diabetes[52]. IGFBP-1 seems to play a role in the development of the decidua.…”

Section: Discussionmentioning

confidence: 99%

Proteomic profiling of amniotic fluid in preterm labor using two-dimensional liquid separation and mass spectrometry

Bujold¹,

Romero²,

Kusanovic³

et al. 2008

The Journal of Maternal-Fetal & Neonatal Medicine

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Objective Simultaneous analysis of the protein composition of biological fluids is now possible. Such an approach can be used to identify biological markers of disease and to understand the pathophysiology of disorders that have eluded classification, diagnosis, and treatment. The purpose of this study was to analyze the differences in protein composition in amniotic fluid of patients in preterm labor. Study Design Amniotic fluid was obtained by amniocenteses from three groups of women with preterm labor and intact membranes: (1) women without intra-amniotic infection/inflammation (IAI) who delivered at term; (2) women without intra-amniotic IAI who delivered a preterm neonate; and (3) women with IAI. Intra-amniotic infection was defined as a positive amniotic fluid culture for microorganisms. Intra-amniotic inflammation was defined as an elevated amniotic fluid interleukin (IL)-6 (≥2.3 ng/mL). Two-dimensional (2D) chromatography was used for analysis. The first dimension separated proteins by isoelectric point, while the second, by the degree of hydrophobicity. 2D protein maps were generated using different experimental conditions (reducing agents as well as protein concentration). The maps were used to discern subsets of isoelectric point/hydrophobicity containing differentially expressed proteins. Protein identification of differentially expressed fractions was conducted with mass spectrometry. ELISA immunoassays as well as surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS)--based on-chip antibody capture immunoassay were also used for confirmation of a specific protein that was differentially expressed. Results 1) Amniotic fluid protein composition can be analyzed using a combination of 2D liquid chromatography and mass spectrometry for the identification of proteins differentially expressed in patients in preterm labor; 2) While total insulin-like growth factor-binding protein-1 (IGFBP-1) concentration did not change, IGFBP-1 fragments at about 13.5 kDa were present in patients with intra-amniotic IAI; 3) proteins which were over-expressed in group 1 included Von Ebner gland protein precursor, IL-7 precursor, apolipoprotein A1, tropomyosin sk1 (TPMsk1) fragment, ribosomal protein S6 kinase alpha-3 and alpha-1-microglobulin/bikunin precursor (AMBP); 4) proteins which were over-expressed in group 3 included fibrinopeptide B, transferrin, (MHC) class 1 chain-related A antigen fragment, transcription elongation factor A, sex-determining region Y (SRY) box 5 protein, Down syndrome critical region 2 protein (DSCR2), and human peptide 8 (HP8); and 5) one protein, retinol binding protein, was over-expressed in women who delivered preterm, regardless of the presence of IAI. Conclusions A combination of techniques involving 2D chromatography, mass spectrometry, and immunoassays allows identification of proteins that are differentially regulated in amniotic fluid of patients with preterm labor. Specifically, the amount of the IGFBP-1 fragments at approximately 13.5 kDa ...

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Relationship between a wide range of alcohol consumptions, components of the insulin-like growth factor system and adiponectin

Cited by 13 publications

References 25 publications

Alcohol and breast cancer risk among Asian-American women in Los Angeles County

Alcohol and breast cancer risk among Asian-American women in Los Angeles County

Association of Mediterranean diet, dietary supplements and alcohol consumption with breast density among women in South Germany: a cross-sectional study

Proteomic profiling of amniotic fluid in preterm labor using two-dimensional liquid separation and mass spectrometry

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