Relationship between age and plasma esterases

Abou-Hatab, Khaled; O'Mahony, M Sinead; Patel, Sarju; Woodhouse, Ken

doi:10.1093/ageing/30.1.41

Cited by 38 publications

(21 citation statements)

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“…Based on this observation, it was suggested that AChE activity could be an excellent enzymatic marker for RBC aging in humans 5 although the plasma activity of AChE has been shown to be unaffected by age in humans 30 . Our results show significant age-dependent decrease in the activity of membrane bound AChE in a mixed a population of red blood cells and is the first report of an agedependent decline in AChE in humans.…”

Section: Resultsmentioning

confidence: 99%

Age-Dependent Decline in Erythrocyte Acetylcholinesterase Activity: Correlation With Oxidative Stress

Jha¹,

Rizvi²

2009

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background:Oxidative stress hypothesis offers a mechanism for the aging process and its involvement in other pathologies such as diabetes and neurodegenerative diseases like Alzheimer. AChE activity in erythrocytes may be considered as a marker of central cholinergic status. The present study was undertaken to (i) determine the activity of erythrocyte AChE as a function of human process (ii) correlate AChE activity with oxidative stress during human aging.Material and Methods: Blood was collected from healthy subjects (n = 37) 22-82 years. Erythrocyte AChE activity, MDA and plasma antioxidant capacity in terms of FRAP was measured spectrophotometrically.Results: There was a marked decrease in AChE activity with increasing age. The reduction in activity of AChE correlated well with increased lipid peroxidation and a decrease in FRAP values.Conclusion: Decreased antioxidant defense, and alteration in membrane rheology during aging process both may contribute towards decreased activity of AChE in erythrocyte membrane. This finding may help in explaining the neuronal complications taking place under conditions of oxidative stress, aging, and dementia.

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Section: Resultsmentioning

confidence: 99%

Age-Dependent Decline in Erythrocyte Acetylcholinesterase Activity: Correlation With Oxidative Stress

Jha¹,

Rizvi²

2009

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…esterases), the effect of age itself has been debated. In a study of 113 healthy subjects aged between 18 and 85 years, no correlation was found between esterase enzyme activity and increasing age (Abou-Hatab et al, 2001). Similarly, for Phase II reactions, physical status has a significant effect on the hepatic drug clearance of medications.…”

Section: Age-associated Physiological Alterations (Physiological Age)mentioning

confidence: 96%

Pharmacotherapy in the ageing patient: The impact of age per se (A review)

Singh

Bajorek

2015

Ageing Research Reviews

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A literature search was carried out to review the influence of 'ageing' on pharmacotherapeutic decision-making, specifically how 'age' is defined and considered in the utilisation of medication. Embase, Medline, International Pharmaceutical Abstracts, and Google scholar were canvassed in a three-tiered search according to pre-established inclusion criteria. In tier 1, a total of 22 studies were identified highlighting the underutilisation of medication in elderly patients, with a particular focus on warfarin. Four studies highlighted an age-bias in medication-prescribing for elderly patients, specifically in relation to medicines for rheumatoid arthritis, angina, and hypertension. Tier 2 identified diverse definitions for 'elderly', including biological age, chronological age, physiological age, as well as various descriptions of 'elderly' in clinical trials and guidelines. Finally, medication optimisation tools were identified through the third tier, emphasising the use of chronological age to describe the 'elderly'. Old age influences pharmacotherapeutic decision-making at various levels, however, what complicates the situation is the absence of a comprehensive definition of 'elderly'. Clinical recommendations need to be based more on objective factors known to affect medication effectiveness and safety.

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“…En 2001, Abou-Hatab y colaboradores no hallaron correlación entre los valores de actividad colinesterásica plasmática y edad, al estudiar 70 personas sanas de 18 a 85 años (22). Lo anterior (1,22) concuerda con nuestros hallazgos, pero debe anotarse que nuestros valores en adultos son francamente superiores a los hallados por Henao y colaboradores (7) en adolescentes de 14-17 años.…”

Section: Monotest® Plasmaunclassified

Valores de referencia de colinesterasa plasmática con los métodos de Michel, EQM y Monotest en población laboral activa del departamento de Antioquia, Colombia.

Fonseca

2003

biomedica

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Colombia carece de valores de referencia autóctonos para colinesterasas plasmáticas (EC 3.1.1.8). El objetivo de este trabajo fue establecer valores de referencia para la población laboral activa afiliada al Seguro Social. Se diseñaron estadísticamente dos muestras, epidemiológicamente representativas de las poblaciones laborales activas del Valle de Aburrá y del cercano oriente antioqueño. Se midió la actividad colinesterásica plasmática por tres métodos (Michel, EQM® y Monotest®) en 415 personas en Aburrá y 412 en Oriente, con edad entre 18 y 49 años. Los promedios de actividad enzimática son estadísticamente similares por región, tanto con el método de Michel como con EQM (Michel: Aburrá, 1,111, y Oriente, 1,125 deltas de pH/hora; EQM: Aburrá, 2,546, y Oriente, 2,476 U/ml). Con Monotest, la media es estadísticamente mayor en Aburrá que en Oriente (5743 y 5459 U/L; p=0,0117). En las dos regiones y con cada método, los hombres tienen niveles de actividad enzimática estadísticamente mayores que las mujeres. Al estratificar por región y sexo, se comprueba que la edad no ejerce influencia significativa en la actividad colinesterásica plasmática, cualquiera que sea el método químico de medición. Nuestros valores son estadísticamente diferentes de los datos extranjeros: con Michel y Monotest, los niveles nuestros son superiores y con EQM son inferiores. Con base en los hallazgos, su interpretación y sus repercusiones, se piensa que estos valores debieran considerarse con prioridad, frente a los foráneos, para la toma de decisiones clínicas y epidemiológicas en el país.Palabras clave: colinesterasa plasmática, Michel, EQM®, Monotest®, valores de referencia, población laboral. Levels of plasma cholinesterase in Colombian working-class populationsReference values for plasma cholinesterase (EC 3.1.1.8) are not available for Colombian populations. A representative sample of a working-class population was used to establish these values to provide reference data for use by the social security system. Two workingclass populations were sampled from the Aburrá Valley (Aburrá) and eastern Antioquia (Oriente). Cholinesterase activity was measured in 827 workers, with ages spanning 18-49 years, 415 from Aburra and 412 people from Oriente. Three methods were used to measure cholinesterase: Michel, EQM® and Monotest®. The average values by Michel and EQM were not statistically different between regions (Michel: Aburrá, 1.11, and East, 1.13 deltas pH/hora; EQM: Aburrá, 2.55, and Oriente, 2.48 U/ml). By the Monotest, the enzyme average was statistically higher in Aburrá than in Oriente (5,743 and 5,459 U/L respectively; p=0.012). By region and technique, men had significantly higher enzymatic levels than women. Within both regions and sexes, no statistically significant difference among the three aged groups was noted. Our obtained Colombian values differed significantly from foreign reference values: Michel and Monotest levels were higher and EQM levels were lower. For making clinical and epidemiologic decisions in Colombia related...

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Relationship between age and plasma esterases

Abstract: age per se is not associated with reductions in the activities of esterase enzymes.

Cited by 38 publications

References 0 publications

Age-Dependent Decline in Erythrocyte Acetylcholinesterase Activity: Correlation With Oxidative Stress

Age-Dependent Decline in Erythrocyte Acetylcholinesterase Activity: Correlation With Oxidative Stress

Pharmacotherapy in the ageing patient: The impact of age per se (A review)

Valores de referencia de colinesterasa plasmática con los métodos de Michel, EQM y Monotest en población laboral activa del departamento de Antioquia, Colombia.

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