Relationship between airway hyperresponsiveness to mannitol and adenosine monophosphate

Abstract

There was a highly significant association between the threshold concentration of AMP and dose of mannitol causing a given fall in FEV1. Further studies are required to evaluate the relationship between inhaled mannitol and other surrogate inflammatory markers.

Relationship between airway responsiveness to mannitol and to methacholine and markers of airway inflammation, peak flow variability and quality of life in asthma patients

“…This concept is supported by the stronger association found between sputum eosinophils and AHR to the indirect stimulus AMP, compared with the association between eosinophils and AHR to the direct stimulus methacholine [4]. Similar findings might be expected using a dry powder of mannitol for inhalation, an indirect stimulus with many features in common with AMP [5,6]. Mannitol acts as an osmotic stimulus to the cells in the airway mucosa and is thought to simulate the dehydration of the airway surface liquid that occurs as a result of evaporative water loss in conditioning the inspired air during exercise [5].…”

“…Mannitol acts as an osmotic stimulus to the cells in the airway mucosa and is thought to simulate the dehydration of the airway surface liquid that occurs as a result of evaporative water loss in conditioning the inspired air during exercise [5]. There is a significant relationship between the sensitivity to mannitol and other tests that act indirectly such as hypertonic saline, exercise, eucapnic hyperpnoea and AMP [6][7][8]. AHR to mannitol has been reported to be associated with improvement in symptom score and forced expiratory volume in 1 s (FEV 1 ) during treatment with inhaled steroids.…”

Prospective Follow-Up of Novel Markers of Bone Turnover in Persistent Asthmatics Exposed to Low and High Doses of Inhaled Ciclesonide over 12 Months

“…Mannitol challenge was measured as described previously with dry powder mannitol challenge (Aridol Pharmaxis Ltd., Sydney, Australia) to determine the PD 10 (15). Assessment of suppression of endogenous cortisol through systemic absorption of ICS was made by quantifying overnight 10-h urinary free cortisol corrected for creatinine (OUCC); this has been shown to be as sensitive as an integrated 24-h serum or urine profile (16).…”

Modern views on the relationship of the upper and lower respiratory tract in allergic rhinitis and asthma

“…В ос-нове ГР лежит обратимая обструкция и фе-номен неадекватного, усиленного ответа ДП на различные специфические и неспецифи-ческие раздражители, в реализации которых принимают участие одни и те же иммуно-опосредованные реакции [6,21]. В патогене-зе АР и БА можно условно выделить три стадии [1]: 1) иммунологическая стадия, характеризующаяся взаимодействием ал-лергена со специфическими аллергически-ми антителами, относящимися к классу IgЕ; 2) патохимическая стадия проявляется спе-цифическим высвобождением медиаторов из тучных клеток и базофилов; 3) патофи-зиологическая стадия, или стадия клиниче-ских проявлений, характеризуется функ-циональными нарушениями, результатом которых являются симптомы аллергическо-го заболевания.…”

“…Для диагностики ГР используют провокационные назальные и ингаля-цилнные тесты (ПНТ и ПИТ) с гистами-ном или метахолином [14,21]. ПИТ с аде-нозином позволяет дифференцировать БА и хроническую обструктивную болезнь легких (ХОБЛ), производить мониторинг противовоспалительной терапии при БА, оценить активность аллергического вос-палительного процесса в ДП и тяжесть заболевания [13].…”