Relationship between angiotensin-converting enzyme gene insertion/deletion polymorphism, angiographically defined coronary artery disease and myocardial infarction in patients with type 2 diabetes mellitus

Narne, Parimala; Ponnaluri, Kamakshi Chaithri; Singh, Shailender; Siraj, Mohammed; Ishaq, Mohammed

doi:10.1177/1470320312448947

Cited by 18 publications

(8 citation statements)

References 43 publications

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“…Many studies showed that polymorphisms of certain genes related to metabolism, including that of ACE, are also associated with the onset and development of Type 2-Diabetes [22, 24 -25]. There is a 287 bp DNA fragment insertion (I) and /or deletion(D) polymorphism in the intron 16 of ACE gene [22,26], which was recently studied [27][28][29][30][31] …”

Section: Introductionmentioning

confidence: 99%

Association of ACE <i>DD</i> Genotype with Hypertension among the Tribal Populations of South India

Paramasivam

Nandakumar

Arumugam

et al. 2016

ILNS

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The Renin-Angiotensin System (RAS) is an important regulator of the blood pressure(BP). The level of the vasoactive peptide Angiotensin-II, is mainly determined by the RAS enzyme, angiotensin converting enzyme-1 (ACE-1). Polymorphisms in ACE gene is reported to be associated with hypertension in various populations worldwide. We investigated the association of ACE I/D polymorphisms with hypertension among the tribal populations of South India. Samples were collected from hypertensive patients (n = 33) and healthy controls (n = 37). Genotyping was performed using Polymerase chain reaction (PCR) with allele specific primers. The DD genotype is significantly observed among the cases (OR = 1.0) . Specifically, the DD genotype is more evident among the females (OR = 0.705) than males (OR = 1.22) and is analysed to be associated with hypertension among the tribal populations of South India.

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Section: Introductionmentioning

confidence: 99%

Association of ACE <i>DD</i> Genotype with Hypertension among the Tribal Populations of South India

Paramasivam

Nandakumar

Arumugam

et al. 2016

ILNS

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“…The relationship of diabetes mellitus with CAD and the I/D polymorphism of the ACE gene revealed a significant relationship with the DD and ID genotypes [42]. In the present study, there was no association between diabetes mellitus and CAD in the genotypes DD (p=0.3874; power=0.1348), ID (p=0.3136; power=0.3136) and II (p=0.4071; power=0.1260).…”

Section: Discussionmentioning

confidence: 36%

A New Investigative Approach: How the Angiotensin-Converting Enzyme Gene Interacts with Coronary Risk Factors

Araújo¹,

Neto²,

Souza³

et al. 2017

J Cardiovasc Dis Diagn

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“…We have previously reported an association of ACE polymorphism with T2DM with neuropathy and gestational diabetes. 11,12 Narne et al showed that it is associated with coronary artery disease (CAD) and myocardial infarction (MI), 15 Ganesan et al showed an association with CAD and T2DM, 16 and Reddy et al showed a significant association between MI and the DD genotype in our population. 17 Because weight and BMI primarily affect the knee joint, we categorized the OA cases into normal, overweight, and obese groups, based on BMI.…”

Section: Discussionmentioning

confidence: 99%

The insertion and deletion (I28005D) polymorphism of the angiotensin I converting enzyme gene is a risk factor for osteoarthritis in an Asian Indian population

Poornima

Subramanyam

Khan

et al. 2014

J Renin Angiotensin Aldosterone Syst

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Introduction: Angiotensin I converting enzyme (ACE) insertion and deletion (I/D) polymorphism has been implicated in the pathogenesis of osteoarthritis (OA). In recent years, numerous genetic factors have been identified and implicated in OA. In this Asian Indian population-based study, we aimed to evaluate the relationship between ACE (I28005D) gene polymorphism and primary OA. We performed a case-control association study to identify and explore the correlation between clinically, radiologically diagnosed individuals with primary knee OA and the ACE I/D polymorphism. Methods: Genomic DNA was isolated from 200 samples, including 100 OA cases and 100 healthy volunteers. DNA was amplified by polymerase chain reaction (PCR) using I and D allele-specific primers. PCR products were assessed via UV visualization of products electrophoresed on 2% agarose gels. Results: The groups differed significantly in genotype distributions (p < 0.05). The primary knee OA group showed a considerably higher incidence of the DD genotype and the D allele compared to the control group (OR = 2.14, 95% CI: 1.10–4.15, p = 0.02 and OR = 2.08, 95% CI: 1.39–3.10, p = 0.0003). Conclusion: The ACE gene polymorphism I28005D was found to be associated with primary knee OA in Asian Indian populations. This is the first study in India to report that the ACE gene polymorphism is a risk factor for early onset primary knee OA.

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Relationship between angiotensin-converting enzyme gene insertion/deletion polymorphism, angiographically defined coronary artery disease and myocardial infarction in patients with type 2 diabetes mellitus

Cited by 18 publications

References 43 publications

Association of ACE <i>DD</i> Genotype with Hypertension among the Tribal Populations of South India

Association of ACE <i>DD</i> Genotype with Hypertension among the Tribal Populations of South India

A New Investigative Approach: How the Angiotensin-Converting Enzyme Gene Interacts with Coronary Risk Factors

The insertion and deletion (I28005D) polymorphism of the angiotensin I converting enzyme gene is a risk factor for osteoarthritis in an Asian Indian population

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