Relationship Between Atherogenic Index of Plasma and Serum Uric Acid in Patients With Untreated Essential Hypertension in China: A Cross-Sectional Study

Ma, Xiaoxiang; Zhang, Xin; Yang, Yanhua; Jiang, Li; Huang, Zhaoyi

doi:10.1177/00033197221141666

Cited by 3 publications

(1 citation statement)

References 36 publications

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“…The p-nitrophenol protocol was used to evaluate ALP activity using the Randox test kit . Atherogenic, cardioprotective, and coronary risk indices were calculated as previously . In brief, the atherogenic index (AI), coronary risk index (CRI), and cardioprotective index (CPI) were calculated as AI = Log [TG/HDL-C], CRI = TC/HDL-C, and CPI= [HDL-C/LDL-C], respectively.…”

Section: Methodsmentioning

confidence: 99%

Anti-Atherosclerosis and Anti-Hyperlipidemia Functions of Terminalia catappa Fruit

Tabansi,

Dahiru,

Patrick

et al. 2023

ACS Omega

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Background: Atherosclerosis is a chronic pathological condition that has remained clinically silent for decades, and the epidemic has continued to be on the rise due to risk factors, including diet, lifestyle, hyperlipidemia, pathogenic microorganisms, and aging. Using various synthetic drugs in treating atherosclerosis is associated with a high risk of myositis, angioedema, myoglobinuria, and acute renal failure. Various side effects of the available drugs have been reported; attempts are underway to explore natural sources with antiatherosclerotic activity. Aim and objective: Using a diet-induced atherosclerosis rat model, the current study tested the hypothesis of antiatherosclerotic and antihyperlipidemic roles of Terminalia catappa fruit extracts. Materials and Methods: Atherosclerosis in Wistar rats was induced using an atherogenic diet. Total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (AP), creatine kinase (CK), and lactate dehydrogenase (LDH) were determined using analytical kits. Results: Quantitative phytochemical analysis of the extracts demonstrated that the plant had flavonoids, saponins, tannins, terpenoids, alkaloids, cardiac glycosides, sterols, phenols, and anthraquinones. Diet-induced atherogenic Wistar rats showed a significant (p < 0.05) increase in total cholesterol, triglyceride, low-density lipoprotein cholesterol, and very low-density lipoprotein cholesterol compared to the healthy control group; however, the atherogenic lipid profile was reversed by the treatment of T. catappa fruit extracts. The biochemical experiments demonstrate that T. catappa fruit extracts have an antihyperlipidaemic effect, shown by a decreased coronary risk index and the atherogenic index, and an increased cardioprotective index, compared to disease control. Conclusion: The current study indicates that T. catappa fruit extracts may contain bioactive molecules to treat atherosclerosis.

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Section: Methodsmentioning

confidence: 99%

Anti-Atherosclerosis and Anti-Hyperlipidemia Functions of Terminalia catappa Fruit

Tabansi,

Dahiru,

Patrick

et al. 2023

ACS Omega

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L-shaped relationship between atherogenic index of plasma with uric acid levels and hyperuricemia risk

Huang,

Chen,

Jie

et al. 2024

Front. Endocrinol.

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BackgroundHyperuricemia is a major risk factor for cardiovascular disease. This study aimed to investigate the relationship between the atherogenic index of plasma (AIP) and serum uric acid (SUA) levels, as well as the risk of hyperuricemia.MethodsUtilizing data from the National Health and Nutrition Examination Survey (NHANES), we conducted a cross-sectional study involving 9,439 participants aged 18 years and above with complete triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) data. AIP was calculated as the logarithm of the ratio of TG to HDL-C. Weighted linear regression, weighted logistic regression, subgroup analysis, generalized additive model, restricted cubic spline and two-part linear and logistic regression were utilized to examine the relationships between AIP and SUA levels and hyperuricemia risk.ResultsWe identified a non-linear and L-shaped relationship between AIP and both SUA levels and hyperuricemia prevalence, with significant increasing observed up to a saturation point (0.588 for uric acid levels and 0.573 for hyperuricemia prevalence). Below these thresholds, the odds ratios (OR) for increased SUA and hyperuricemia were 0.854 (95% confidence interval [CI]: 0.762, 0.946) and 4.4 (95% CI: 3.528, 5.488), respectively (P<0.001). Beyond these points, the associations were not statistically significant.ConclusionOur findings suggest that AIP is significantly and non-linear associated with SUA levels and hyperuricemia risk, with a saturation effect observed beyond specific thresholds. These insights could inform clinical strategies for managing cardiovascular and metabolic risks associated with elevated AIP. Further longitudinal studies are warranted to confirm these associations and elucidate the underlying mechanisms.

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A Cross Sectional Study of Association Between Serum Uric Acid and Lipid Profile

Khan¹,

Baseer²,

Ahmed³

2022

Global Journal for Research Analysis

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Background: The association of Serum Uric Acid (SUA) with Lipid Prole is not well studied or little is known so far, although the link between elevated uric acid and metabolic syndrome has been reported in some studies. This study was conducted to establish the relationship between SUA and Lipid Prole among the general adults. Methods: 560 blood samples were collected from general adult participants (male, n = 300 & female, n = 260) were analysed for serum lipid prole (TC, TG, HDL and LDL) and SUA levels. The study subjects were divided by quartiles based on SUA levels (Q1: ≤225 μmol/L, Q2: 226–285 μmol/L, Q3: 286–340 μmol/L and Q4: > 340 μmol/L). Linear regression modelling was used to evaluate the relationship between SUA and Lipid levels. Results: The prevalence of hyperuricemia was 9.2% in males and 10.4% in females. The mean level of SUA was signicantly higher in male (317 ± 90 μmol/L) than in the female (255 ± 65 μmol/L) subjects (p < 0.001). An increasing trend for elevated lipid prole was observed in both genders with increasing levels of SUA in the quartiles (p < 0.05). In regression analysis, a signicant positive correlation was found between SUA and TG, TC and LDL (p < 0.01) while an inverse correlation was observed between SUA and HDL (p < 0.01). After adjusting for potential confounders, lipid prole was linearly associated with SUA levels (p < 0.01 for trend). Conclusions: Lipid parameters (TG, TC, and LDL levels) increases with increase in SUA, whereas HDL decreases with rise in SUA. Cardiovascular risks may be reduced by early prevention of hyperuricemia and dyslipidaemias.

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Relationship Between Atherogenic Index of Plasma and Serum Uric Acid in Patients With Untreated Essential Hypertension in China: A Cross-Sectional Study

Cited by 3 publications

References 36 publications

Anti-Atherosclerosis and Anti-Hyperlipidemia Functions of Terminalia catappa Fruit

Anti-Atherosclerosis and Anti-Hyperlipidemia Functions of Terminalia catappa Fruit

L-shaped relationship between atherogenic index of plasma with uric acid levels and hyperuricemia risk

A Cross Sectional Study of Association Between Serum Uric Acid and Lipid Profile

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