Relationship between butyrylcholinesterase activity and lipid parameters in workers occupationally exposed to pesticides

Molina-Pintor, I.B.; Rojas-García, Aurora Elizabeth; Bernal-Hernández, Yael Yvette; Medina-Díaz, Irma Martha; González-Arias, Cyndia Azucena; Barrón-Vivanco, Briscia Socorro

doi:10.1007/s11356-020-08197-2

Cited by 6 publications

(4 citation statements)

References 57 publications

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“…We found that urinary DMTP and DETP concentrations were negatively associated with serum ALB and TP levels. Our observations were consistent with previous studies that showed a positive correlation between butyrylcholinesterase activity (inhibited by elevated OP concentrations) and serum albumin concentrations 32 . The detailed mechanisms for this association still need to be illustrated.…”

Section: Discussionsupporting

confidence: 92%

“…Our observations were consistent with previous studies that showed a positive correlation between butyrylcholinesterase activity (inhibited by elevated OP concentrations) and serum albumin concentrations. 32 The detailed mechanisms for this association still need to be illustrated. The interactions between OPs and ALB have drawn increasing attention, as their adducts could be potentially used as biomarkers of OP exposure.…”

Section: Discussionmentioning

confidence: 99%

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Organophosphate pesticide exposure and biomarkers of liver injury/liver function

Xiao

et al. 2022

Liver International

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Background and Aims There is little epidemiological evidence linking the exposure of organophosphate pesticides (OPs) to liver function or liver injury in the general population. We used data from the National Health and Nutrition Examination Survey 1999–2012 to investigate the relationship of urinary OPs with biomarkers of liver function/liver injury. Methods The exposures were the concentrations of urinary OP metabolites (dimethyl phosphate [DMP], dimethyl thiophosphate [DMTP], diethyl phosphate [DEP] and diethyl thiophosphate [DETP]). The health outcomes were biomarkers of liver function/liver injury. The multivariable linear regression model, restricted cubic splines (RCSs) analysis and weighted quantile sum (WQS) regression were used to evaluate the relationship between individual or overall exposure of OPs and outcomes. Results Regressions of RCSs suggested linear and positive associations of OP metabolites with aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio (DMP and DEP) and fibrosis‐4 (FIB‐4) index (DMP, DEP and DMTP) (all p–non‐linear values >.05). However, L‐shaped relationships were found between OP metabolites (DMTP and DETP) and blood albumin and total protein (TP) concentrations (both p and non‐linear values <.05). The positive associations of urinary DMP, DEP and DMTP with AST/ALT ratio, and with FIB‐4 score were more pronounced among non‐smokers than smokers, among alcohol drinkers than non‐drinkers and among those with a body mass index (BMI) of ≥25 than participants with a BMI of <25. However, most of the interaction p values were more than .05, indicating no significant interactions between covariates and OPs on outcomes mainly including AST/ALT, FIB‐4, ALB and TP levels. Finally, the WQS indices were positively associated with AST/ALT ratio (p = .014) and FIB‐4 score (p = .002). Conclusions Our study added novel evidence that exposures to OPs might be adversely associated with the biomarkers of liver function/liver injury. These findings indicated the potential toxic effect of OP exposures on the human liver.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Organophosphate pesticide exposure and biomarkers of liver injury/liver function

Xiao

et al. 2022

Liver International

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“…In a recent study, positive correlations were observed between BChE activity and lipid parameters. These effects have been associated with body mass index (Molina-Pintor et al, 2020). Currently, in AD drugs such as rivastigmine, which target both BChE and AChE, are the better choice of drugs (Ballard, 2002).…”

Section: Bche and Lipid Me Tabolis M: Future Outcome Smentioning

confidence: 99%

Butyrylcholinesterase in lipid metabolism: A new outlook

Gok

Çiçek

Bodur

2023

Journal of Neurochemistry

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Cholinesterase enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are traditionally associated with the termination of acetylcholine mediated neural signaling. The fact that these ubiquitous enzymes are also found in tissues not involved in neurotransmission has led to search for alternative functions for these enzymes. Cholinesterases are reported to be involved in many lipid related disease states. Taking into view that lipases and cholinesterases belong to the same enzyme class and by comparing the catalytic sites, we propose a new outlook on the link between BChE and lipid metabolism. The lipogenic substrates of BChE that have recently emerged in contrast to traditional cholinesterase substrates are explained through the hydrolytic capacity of BChE for ghrelin, 4‐methyumbelliferyl (4‐mu) palmitate, and arachidonoylcholine and through endogenous lipid mediators such as cannabinoids like anandamide and essential fatty acids. The abundance of BChE in brain, intestine, liver, and plasma, tissues with active lipid metabolism, supports the idea that BChE may be involved in lipid hydrolysis. BChE is also regulated by various lipids such as linoleic acid, alpha‐linolenic acid or dioctanoylglycerol, whereas AChE is inhibited. The finding that BChE is able to hydrolyze 4‐mu palmitate at a pH where lipases are less efficient points to its role as a backup in lipolysis. In diseases such as Alzheimer, in which elevated BChE and impaired lipid levels are observed, the lipolytic activity of BChE might be involved. It is possible to suggest that fatty acids such as 4‐mu palmitate, ghrelin, arachidonoylcholine, essential fatty acids, and other related lipid mediators regulate cholinesterases, which could lead to some sort of compensatory mechanism at high lipid concentrations.image

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“…A link may exist between metabolic syndrome, diabetes and obesity and the modulation of this enzyme activity. Indeed, the study of Molina-Pintor et al (Molina-Pintor et al, 2020) aimed at evaluating the lipid parameters in urban sprayers and their association with BuChE activity. This group showed that the level of exposures to pesticides was correlated to variations in glucose, cholesterol, albumin, atherogenic index, creatinine, LDL, VLDL, triglycerides and total lipids in people suffering from overweight and obesity.…”

Section: Pesticides Residues and Metabolic Disorders 211 Organophosph...mentioning

confidence: 99%

How advanced are we on the consequences of oral exposure to food contaminants on the occurrence of chronic non communicable diseases?

et al. 2022

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Relationship between butyrylcholinesterase activity and lipid parameters in workers occupationally exposed to pesticides

Cited by 6 publications

References 57 publications

Organophosphate pesticide exposure and biomarkers of liver injury/liver function

Organophosphate pesticide exposure and biomarkers of liver injury/liver function

Butyrylcholinesterase in lipid metabolism: A new outlook

How advanced are we on the consequences of oral exposure to food contaminants on the occurrence of chronic non communicable diseases?

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