Relationship between changes in selected thrombotic and inflammatory factors, echocardiographic parameters and the incidence of venous thrombosis after pacemaker implantation based on our own observations

Lelakowski, Jacek; Domagała, Teresa; Rydlewska, Anna; Januszek, Rafał; Kotula−Horowitz, Katarzyna; Majewski, Jacek; Ząbek, Andrzej; Małecka, Barbara

doi:10.5114/aoms.2012.28600

Cited by 15 publications

(15 citation statements)

References 13 publications

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“…The expressive rate of the study endpoints confirmed the observation of clinical practice that these problems are frequent after intravascular manipulation of patients with CIED and allowed the search for risk factors 9‐11,19 . Among the variables that were associated with the occurrence of UEDVT, two were independent predictors: the collateral circulation present in preoperative venography, which increased by 4.7 times the chance of this outcome and the transvenous lead extraction, which increased 27 times this risk.…”

Section: Discussionsupporting

confidence: 65%

Upper extremity deep venous thrombosis and pulmonary embolism after transvenous lead replacement or upgrade procedures

Albertini

Silva

Lima

et al. 2020

Pacing Clinical Electrophis

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Background: Venous obstructions are frequent in patients with transvenous leads, although related clinical findings are rarely reported. After lead replacement or upgrade procedures, these lesions are even more frequent, but there is still no evidence to support this observation. Aim: To investigate the incidence and possible risk factors for upper extremity deep venous thrombosis (UEDVT) and pulmonary embolism (PE) after lead replacement or upgrade procedures. Methods: Prospective cohort carried out between April 2013 and July 2016. Preoperative evaluation included venous ultrasound and pulmonary angiotomography. Diagnostic exams were repeated postoperatively to detect the study outcomes. Multivariate logistic regression models were used to identify prognostic factors. Results: Among the 84 patients included, 44 (52.4%) were female and mean age was 59.3 ± 15.2 years. Lead malfunctioning (75.0%) was the main surgical procedure indication. Lead removal was performed in 44 (52.4%) cases. The rate of postoperative combined events was 32.6%, with 24 (28.6%) cases of UEDVT and six (7.1%) cases of PE. Clinical manifestations of deep venous thrombosis occurred in 10 (11.9%) patients. Independent prognostic factors for UEDVT were severe collateral circulation in the preoperative venography (odds ratio [OR] 4.7; 95% confidence interval[CI] 1.1-19.8; P = .037) and transvenous lead extraction (OR 27.4;; P < .0001). Conclusion:Reoperations involving previously implanted transvenous leads present high rates of thromboembolic complications. Transvenous lead extraction had a significant impact on the development of UEDVT. These results show the need of further studies to evaluate the role of preventive strategies for this subgroup of patients.

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Section: Discussionsupporting

confidence: 65%

Upper extremity deep venous thrombosis and pulmonary embolism after transvenous lead replacement or upgrade procedures

Albertini

Silva

Lima

et al. 2020

Pacing Clinical Electrophis

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“…PAI-1 also plays an active role in this process 1 . In the present study, although the caval clots were not spontaneously formed, we found evidence that similar biochemical markers may play role in the process of propagation 33 34 .…”

Section: Discussionsupporting

confidence: 42%

Swine Model of Thrombotic Caval Occlusion Created by Autologous Thrombus Injection with Assistance of Intra-caval Net Knitting

Shi

et al. 2015

Sci Rep

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To evaluate the feasibility of a swine model of thrombotic inferior vena cava (IVC) occlusion (IVCO) created by autologous thrombus injection with assistance of intra-caval net knitting. Sixteen pigs were included and divided into two groups: Group A (n = 10), IVCO model created by knitting a caval net followed by autologous thrombus injection; Group B (n = 6), control model created by knitting a net and normal saline injection. Venography was performed to assess each model and the associated thrombotic occlusion. The vessels were examined histologically to analyse the pathological changes postoperatively. IVCO model was successfully created in 10 animals in Group A (100%). Immediate venography showed extensive clot burden in the IVC. Postoperative venography revealed partial caval occlusion at 7 days, and complete occlusion coupled with collateral vessels at 14 days. Histologically, Group A animals had significantly greater venous wall thickening, with CD163-positive and CD3-positive cell infiltration. Recanalization channels were observed at the margins of the thrombus. By contrast, no thrombotic occlusion of the IVC was observed in Group B. The thrombotic IVCO model can be reliably established in swine. The inflammatory reaction may contribute to the caval thrombus propagation following occlusion.

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“…These risk factors included pacemakers19, splenectomy20, non-0 blood type21, lupus anticoagulant22, thyroid replacement therapy/subacute hypothyroidism23, malignancy24 and age10.…”

Section: Discussionmentioning

confidence: 99%

Fibrinogen plasma concentration is an independent marker of haemodynamic impairment in chronic thromboembolic pulmonary hypertension

Hennigs

Baumann

Lüneburg

et al. 2014

Sci Rep

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Fibrinogen has a crucial role in both inflammation and coagulation, two processes pivotal for the pathogenesis of pulmonary hypertension. We therefore aimed to investigate whether fibrinogen plasma concentrations a) are elevated in pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) and b) may serve as a novel biomarker for haemodynamic impairment. In a dual-centre, retrospective analysis including 112 patients with PAH (n = 52), CTEPH (n = 49) and a control cohort of patients with suspected PAH ruled out by right heart catheterisation (n = 11), we found fibrinogen plasma concentrations to be increased in patients with PAH (4.1 ± 1.4 g/l) and CTEPH (4.3 ± 1.2 g/l) compared to control patients (3.4 ± 0.5 g/l, p = 0.0035 and p = 0.0004, respectively). In CTEPH patients but not in PAH patients fibrinogen was associated with haemodynamics (p < 0.036) and functional parameters (p < 0.041). Furthermore, fibrinogen was linked to disease severity (WHO functional class, p = 0.017) and independently predicted haemodynamic impairment specifically in CTEPH (p < 0.016). Therefore, fibrinogen seems to represent an important factor in CTEPH pathophysiology and may have the potential to guide clinical diagnosis and therapy.

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Relationship between changes in selected thrombotic and inflammatory factors, echocardiographic parameters and the incidence of venous thrombosis after pacemaker implantation based on our own observations

Cited by 15 publications

References 13 publications

Upper extremity deep venous thrombosis and pulmonary embolism after transvenous lead replacement or upgrade procedures

Upper extremity deep venous thrombosis and pulmonary embolism after transvenous lead replacement or upgrade procedures

Swine Model of Thrombotic Caval Occlusion Created by Autologous Thrombus Injection with Assistance of Intra-caval Net Knitting

Fibrinogen plasma concentration is an independent marker of haemodynamic impairment in chronic thromboembolic pulmonary hypertension

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