Relationship Between Chronic Kidney Disease and White Matter Hyperintensities on Magnetic Resonance Imaging

Takahashi, Wakoh; Tsukamoto, Yuuko; Takizawa, Shunya; Kawada, Shiaki; Takagi, Shigeharu

doi:10.1016/j.jstrokecerebrovasdis.2010.03.015

Cited by 36 publications

(36 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many studies demonstrated a strong influence of age out of several risk factors involved in development of WMLs [6][7][8][9]14,15]. Age was also an independent risk factor for the presence or absence of DSWMH and PVH, which are WMLs, in our study.…”

Section: Discussionsupporting

confidence: 74%

Risk Factors Association with Severity of White Matter Lesions on Magnetic Resonance Imaging

Nemoto¹,

Masuda²,

Harada³

et al. 2017

Gen Med

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 74%

Risk Factors Association with Severity of White Matter Lesions on Magnetic Resonance Imaging

Nemoto¹,

Masuda²,

Harada³

et al. 2017

Gen Med

View full text Add to dashboard Cite

show abstract

“…Furthermore, impaired kidney function is associated with cerebral small-vessel disease, independent of other classical vascular risk factors 6,20. The association between impaired kidney function and small-vessel pathologies in strictly nonlobar areas may be ascribed to the anatomical similarities between the vessels and the mechanism underlying dysfunction of the endothelial and smooth-muscle cells 21.…”

Section: Discussionmentioning

confidence: 99%

Distribution of Cerebral Microbleeds Determines Their Association with Impaired Kidney Function

et al. 2014

View full text Add to dashboard Cite

Background and PurposeCerebral microbleeds (CMBs) are associated with various pathologies of the cerebral small vessels according to their distribution (i.e., cerebral amyloid angiopathy or hypertensive angiopathy). We investigated the association between CMB location and kidney function in acute ischemic stroke patients.MethodsWe enrolled 1669 consecutive patients with acute ischemic stroke who underwent gradient-recalled echo brain magnetic resonance imaging. Kidney function was determined using the estimated glomerular filtration rate (eGFR). CMBs were classified into strictly lobar, strictly nonlobar (i.e., only deep or infratentorial), and a combination of both lobar and nonlobar. Multinomial logistic regression analyses were used to determine the factors associated with the existence of CMBs according to their location.ResultsThe patients were aged 66±12 years (mean±standard deviation), and 61.9% (1033/1669) of them were male. CMBs were found in 27.0% (452/1669) of the patients. The stroke subtypes of small-artery occlusion and cardioembolism occurred more frequently in those with strictly nonlobar CMBs (10.8%) and strictly lobar CMBs (48.8%), respectively. The mean eGFR was lower in the strictly nonlobar CMBs group (72±28 mL/min/1.73 m2) and the both lobar and nonlobar CMBs group (72±25 mL/min/1.73 m2) than in the no-CMBs group (86±29 mL/min/1.73 m2). Multivariate multinomial logistic regression revealed that eGFR <60 mL/min/1.73 m2 was independently related to strictly nonlobar CMBs (odds ratio=2.63, p=0.001).ConclusionsImpaired kidney function is associated with strictly nonlobar CMBs. Our findings indicate that the distribution of CMBs should be considered when evaluating their relationships or prognoses.

show abstract

“…13 Accordingly, WMHs were most prevalent in this low eGFR group. 13,23 Because hyperfiltration might precede chronic kidney impairment, prevalence of risk factors in this group is of special interest. 7,24 Hyperfiltration (eGFR Ն120 mL/min) was 14.4% more frequent than in a recently published Finnish cohort.…”

Section: Discussionmentioning

confidence: 99%

Kidney Function and White Matter Disease in Young Stroke Patients

Steinicke

Gaertner²,

Grittner³

et al. 2012

Stroke

View full text Add to dashboard Cite

show abstract

Relationship Between Chronic Kidney Disease and White Matter Hyperintensities on Magnetic Resonance Imaging

Cited by 36 publications

References 26 publications

Risk Factors Association with Severity of White Matter Lesions on Magnetic Resonance Imaging

Risk Factors Association with Severity of White Matter Lesions on Magnetic Resonance Imaging

Distribution of Cerebral Microbleeds Determines Their Association with Impaired Kidney Function

Kidney Function and White Matter Disease in Young Stroke Patients

Contact Info

Product

Resources

About