Relationship between circulating sex steroid hormone concentrations and incidence of total knee and hip arthroplasty due to osteoarthritis in men

Hussain, Sultana Monira; Cicuttini, Flavia Maria; Giles, Graham G.; Graves, Stephen; Wang, Yuanyuan

doi:10.1016/j.joca.2016.04.008

Cited by 18 publications

(15 citation statements)

References 16 publications

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“…After menopause, women have increased osteoarthritis risk. However, only a few studies have investigated the association between testosterone deficiency and osteoarthritis risk in elderly men, and those results have been inconsistent [ 1 , 2 ]. However, serum testosterone concentrations are positively associated with cartilage volume, but the loss of cartilage volume for 2 years does not induce osteoarthritis [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, serum testosterone concentrations are positively associated with cartilage volume, but the loss of cartilage volume for 2 years does not induce osteoarthritis [ 2 ]. In a prospective cohort study, osteoarthritis risk is associated with lower serum androstenedione concentrations in obese and overweight men [ 1 ]. Therefore, lowering circulating serum concentrations of sex hormones may influence osteoarthritis etiology in men.…”

Section: Introductionmentioning

confidence: 99%

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Aqueous Extracts of Morus alba Root Bark and Cornus officinalis Fruit Protect against Osteoarthritis Symptoms in Testosterone-Deficient and Osteoarthritis-Induced Rats

et al. 2020

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Water extracts of both Morus alba L. root bark (MBW) and Cornus officinalis Siebold and Zucc fruit (CFW) have traditionally been used to promote men’s health in the elderly in Asia. We determined that the 12-week consumption of MBW and CFW could alleviate testosterone-deficiency syndrome and osteoarthritis (OA) symptoms in testosterone-deficient rats, and the action mechanisms were explored. Rats with bilateral orchiectomy (ORX) were fed a 45% fat diet containing either 0.5% MBW (ORX-MBW), 0.5% CFW(ORX-CFW), or 0.5% dextrin (ORX-CON). Sham-operated rats also received 0.5% dextrin (Non-ORX-CON). After 8 weeks of treatment, all rats had an injection of monoiodoacetate (MIA) into the left knee, and they continued the same diet for the additional 4 weeks. ORX-CFW and ORX-MBW partially prevented the reduction of serum testosterone concentrations and decreased insulin resistance, compared to the ORX-CON. ORX-CFW and ORX-MBW protected against the reduction of bone mineral density (BMD) and lean body mass (LBM) compared to the ORX-CON. The limping and edema scores were lower in the order of the ORX-CON, ORX-CRF = ORX-MBW, and Non-ORX-CON (p < 0.05). The scores for pain behaviors, measured by weight-distribution on the OA leg and maximum running velocity on a treadmill, significantly decreased in the same order as limping scores. ORX-MBW protected against the increased expression of matrix metalloproteinase (MMP)-3 and MMP-13 and reduced the production of inflammatory markers such as TNF-α and IL-1β, by MIA in the articular cartilage, compared to the ORX-CON (p < 0.05). The cartilage damage near the tidemark of the knee and proteoglycan loss was significantly less in ORX-MBW than ORX-CON. In conclusion, MBW, possibly CFW, could be effective alternative therapeutic agents for preventing osteoarthritis in testosterone-deficient elderly men.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Aqueous Extracts of Morus alba Root Bark and Cornus officinalis Fruit Protect against Osteoarthritis Symptoms in Testosterone-Deficient and Osteoarthritis-Induced Rats

et al. 2020

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“…In animals, research suggests that Androstenedione has been linked to increasing bone mineral density (BMD) at metaphyseal and diaphyseal femoral regions as well as bone mineral quality and quantity of cancellous and cortical bone. The findings, however, do not clarify whether or not such effects come from a direct action of Androstenedione itself or the involvement of aromatase in the conversion of the steroid precursor to T, E2 or Ag within bone tissue [9], [13], [18].…”

Section: The Importance Of Aromatase In Hormonal Regulationmentioning

confidence: 69%

“…Osteoarthritis (OA) is a major degenerative joint disease which can affect more than one quarter of the global population in individuals over the age of 18. This disease is typically defined by the following observations: progressive loss of articular cartilage, thickening of the subchondral bone, and formation of osteophyte, significant inflammation of the synovial as well as degeneration of ligaments and menisci of the knee and hypertrophy of the joint capsule.…”

Section: Introductionmentioning

confidence: 99%

Correlation between Sex Hormone Deficiency and Osteoarthritis

Macedo¹,

Santos²,

Lana³

et al. 2018

Journal of Bone Biology and Osteoporosis

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This literature review explores recent and past investigations carried out by researchers in various settings pertaining to the orthopaedic field of medicine, in attempts to show a possible connection between the deficit in sex hormone levels and the potential consequences it brings about on orthopaedic health, namely, osteoarthritis. There is some evidence in the literature suggesting that suboptimal concentrations of steroid hormones can negatively impact bone health, making it more susceptible to physical injury, especially when the hormone in question is estrogen. Several studies have shown that this biomolecule is quite essential to human health due to its effects on not only sexual development and function but also on bone metabolism, in both men and women. Investigations revolving around estrogenic compounds reveal their significance in physical capacitation of adult individuals, since it has already been found that estrogens play a pivotal role on bone maintenance by directly interacting with osteocytes, osteoblasts, osteoclasts and even T-cells, to name a few examples. Large scale studies also bring up plausible evidence by evaluating the links between measured sex steroid concentrations and incidence of osteoarthritic joint replacement in adults. Taking that into consideration, there is sufficient motivation to look into hormonal fluctuation in adult individuals, calling for suitable medical intervention in order to keep a patient’s health under control, avoiding and even treating the detrimental effects caused by the deficiency of certain steroid hormones.

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“…persists for testosterone and estrogen between males and females, but notable differences have also been described for other hormones, including leptin [16][17][18][19] . The role that estrogen plays in OA has been well defined, as decreased expression of this hormone directly correlates to enhanced OA incidence [20][21][22] .…”

Section: Numerous Reports Have Highlighted the Varied Mechanisms Of Amentioning

confidence: 99%

Characterization of OA development between sexes in the rat medial meniscal transection model

Pucha

McKinney

Fuller

et al. 2019

Preprint

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AbstractObjectiveOsteoarthritis (OA) is a chronic degenerative disease of the joints characterized by articular cartilage degradation. While there are clear sex differences in OA development in humans, most pre-clinical research has been conducted solely in male animals thus limiting the ability of these findings to be generalized to both sexes in the context of this disease. The objective of this study was to determine if sex impacts the progression and severity of OA in the rat medial meniscal tear (MMT) preclinical animal model used to surgically induce OA. It was hypothesized that differences would be observed between males and females following MMT surgery.DesignA MMT model was employed in male and female Lewis rats to induce OA. Animals were euthanized 3 weeks post-surgery and EPIC-μCT was used to quantitatively evaluate articular cartilage structure and composition, osteophyte volumes and subchondral bone structure.ResultsQuantitative analysis of the medial 1/3 articular cartilage via EPIC-μCT showed increased cartilage thickness and proteoglycan loss in the MMT of both sexes, when compared to sham. Additionally, both male and female animals in the MMT group had increased subchondral bone mineral density and larger total osteophyte volumes due to MMT.ConclusionThese data demonstrate that OA can be induced in both sexes using the rat MMT model. Moving forward, adding sex as a factor in preclinical OA studies should be standard practice in pre-clinical studies in order to elucidate more inclusive and translatable results into the clinic.

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Relationship between circulating sex steroid hormone concentrations and incidence of total knee and hip arthroplasty due to osteoarthritis in men

Cited by 18 publications

References 16 publications

Aqueous Extracts of Morus alba Root Bark and Cornus officinalis Fruit Protect against Osteoarthritis Symptoms in Testosterone-Deficient and Osteoarthritis-Induced Rats

Aqueous Extracts of Morus alba Root Bark and Cornus officinalis Fruit Protect against Osteoarthritis Symptoms in Testosterone-Deficient and Osteoarthritis-Induced Rats

Correlation between Sex Hormone Deficiency and Osteoarthritis

Characterization of OA development between sexes in the rat medial meniscal transection model

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