Relationship between compression pressure, mechanical strength and release properties of tablets

Adeleye, Olutayo Ademola

doi:10.17219/pim/111888

Cited by 13 publications

(13 citation statements)

References 25 publications

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“…Crushing strength is used to determine the strength of a tablet and it is dependent on the binder and compression pressure. [24][25] There was significant difference (p<0.01) in the crushing strength. The Pharmacopeia specification for friability is ≤1%.…”

Section: Effect Of Chitosan As a Binder On Tablet Propertiesmentioning

confidence: 90%

Characterization of Chitosan Obtained from Snail Shell (Achatina fulica) and its Excipient Potentials in Metronidazole Tablet Formulation

Bamiro

Salisu

Iyere

et al. 2021

Dhaka Univ. J. Pharm. Sci

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The aim of the work was to characterize chitosan extracted from snail shell and evaluate its use as a disintegrant and binder in metronidazole tablet formulation in comparison with standard chitosan (SC). The mechanical properties were assessed using crushing strength and friability, while the release properties were assessed using disintegration and dissolution times. The extracted chitosan (EC) was crystalline in nature and the scanning electron microscopy (SEM) showed polygonal particles with rough surface. The moisture and swelling capacity was 1.80% and 15.00%, respectively. The densities and flow properties were significantly (p<0.05) higher than those of the SC. As a binder, the crushing strength of formulations containing EC was higher than SC, but both formulation failed friability test. There was significant difference between the disintegration times of the metronidazole formulations containing EC and SC as a disintegrant. The result showed that EC is more effective as a binder in tablet formulations. Dhaka Univ. J. Pharm. Sci. 20(1): 31-39, 2021 (June)

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Section: Effect Of Chitosan As a Binder On Tablet Propertiesmentioning

confidence: 90%

Characterization of Chitosan Obtained from Snail Shell (Achatina fulica) and its Excipient Potentials in Metronidazole Tablet Formulation

Bamiro

Salisu

Iyere

et al. 2021

Dhaka Univ. J. Pharm. Sci

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“…This increase in porosity was associated with an increase in hardness. In conventional methods, hardness and porosity are correlated to the compression force, where increasing the force can decrease porosity and increase hardness [ 34 ]. Thus, hardness and porosity are inversely correlated.…”

Section: Resultsmentioning

confidence: 99%

An Insight into the Impact of Thermal Process on Dissolution Profile and Physical Characteristics of Theophylline Tablets Made through 3D Printing Compared to Conventional Methods

et al. 2022

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The dissolution profile is of great importance in drug delivery and is affected by the manufacturing method. Thus, it is important to study the influence of the thermal process on drug release in emerging technologies such as 3D printing-fused deposition modeling (FDM). For this purpose, the characteristics of 3D printed tablets were compared to those of tablets prepared by other thermal methods such as hot-melt extrusion (HME) and non-thermal methods such as physical mixture (PM). Theophylline was used as a drug model and blends of ethyl cellulose (EC) and hydroxypropyl cellulose (HPC) were used as a matrix former. The solid state of the drug in all formulations was investigated by differential scanning calorimetry, X-ray powder diffraction, and Fourier-transformed infrared spectroscopy. All studied tablets had the same weight and surface area/volume (SA/V). Dissolution data showed that, for some formulations, printed tablets interestingly had a faster release profile despite having the highest hardness values (>550 N) compared to HME and PM tablets. Porosity investigations showed that 100% infill printed tablets had the highest porosity (~20%) compared to HME (<10%) and PM tablets (≤11%). True density records were the lowest in printed tablets (~1.22 g/m3) compared to tablets made from both HME and PM methods (~1.26 g/m3), reflecting the possible increase in polymer specific volume while printing. This increase in the volume of polymer network may accelerate water and drug diffusion from/within the matrix. Thus, it is a misconception that the 3D printing process will always retard drug release based on increased tablet hardness. Hardness, porosity, density, solid-state of the drug, SA/V, weight, and formulation components are all factors contributing to the release profile where the total balance can either slow down or accelerate the release profile.

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“…Main pressure was a parameter with the most decisive influence on API 1 dissolution and the second most important parameter affecting API 2. Generally, an increase in the main-pressure should decrease the release properties of tablets, but this is not always the case since tablet production results from complex interactions between incoming materials and process variables [1]. This is the reason why interactions were mainly non-linear and cannot be clearly described with linear methods (Figure 6).…”

Section: Influence Of Process Parametersmentioning

confidence: 99%

Artificial Neural Networks for Investigation of the Most Important Factors of Industrial Tablet Manufacturing on the Dissolution of Active Pharmaceutical Ingredients as Critical Quality Attributes

Prikeržnik¹

2021

FARMACIA

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This research aimed to show the usefulness of artificial neural networks (ANNs) to investigate significant factors on the biopharmaceutical relevant parameter. It is the first time ANNs were used on such a comprehensive set of data collected during two-years of industrial production of tablets containing two active pharmaceutical ingredients (APIs). The feature selection technique was applied to the ANNs models to recognize critical material attributes and process parameters. Altogether, we have identified seven critical material attributes related to APIs, croscarmellose sodium, magnesium stearate, and colloidal silicon dioxide, together with five critical process parameters related to the roller compaction and tablet compression. The study demonstrates the usefulness of ANNs in facilitating a higher level of tablet manufacturing understanding. RezumatStudiul a evaluat utilitatea rețelelor neuronale artificiale (ANN) cu scopul de a investiga factori ce influențează semnificativ parametri biofarmaceutici. Astfel, ANN-urile au fost aplicate pe un set cuprinzător de date colectate pe parcursul a doi ani de producție industrială a comprimatelor ce conțin două ingrediente farmaceutice active (API). Tehnica de selectare a caracteristicilor a fost aplicată modelelor ANN pentru a recunoaște atributele materiale critice și parametri procesului. În total, au fost identificate șapte atribute materiale critice legate de API, croscarmeloză sodică, stearat de magneziu și dioxid de siliciu coloidal, împreună cu cinci parametri critici ai proceselor de compactare și comprimare. Studiul demonstrează utilitatea ANN-urilor în facilitarea înțelegerii procesului de obținere a comprimatelor.

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Relationship between compression pressure, mechanical strength and release properties of tablets

Abstract: Adeleye OA. Relationship between compression pressure, mechanical strength and release properties of tablets.

Cited by 13 publications

References 25 publications

Characterization of Chitosan Obtained from Snail Shell (Achatina fulica) and its Excipient Potentials in Metronidazole Tablet Formulation

Characterization of Chitosan Obtained from Snail Shell (Achatina fulica) and its Excipient Potentials in Metronidazole Tablet Formulation

An Insight into the Impact of Thermal Process on Dissolution Profile and Physical Characteristics of Theophylline Tablets Made through 3D Printing Compared to Conventional Methods

Artificial Neural Networks for Investigation of the Most Important Factors of Industrial Tablet Manufacturing on the Dissolution of Active Pharmaceutical Ingredients as Critical Quality Attributes

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