Relationship between copper exposure duration, tissue copper concentration, and rainbow trout growth

Marr, John C.; Lipton, Joshua; Cacela, Dave; Hansen, James A.; Bergman, Harold L.; Meyer, Joseph S.; Högstrand, Christer

doi:10.1016/s0166-445x(96)00801-6

Cited by 91 publications

(53 citation statements)

References 24 publications

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“…This result suggests that the increased hepatic copper concentrations seen at day 21 in the current study may have increased further if the exposure had continued. Further support of the potential for hepatic copper concentrations to increase after 21 days of exposure is provided by a study of rainbow trout fry in which whole-body copper concentrations reached steadystate between 40 and 60 days of exposure to copper (Marr et al 1996). The variability in the hepatic copper concentrations that were measured within each treatment in the current study suggests that the response of individual fish with respect to copper uptake and elimination varied considerably.…”

Section: Hepatic Copper and Metallothioneinsupporting

confidence: 54%

The Effects of Copper on Blood and Biochemical Parameters of Rainbow Trout (Oncorhynchus mykiss)

Dethloff¹,

Schlenk²,

Khan³

et al. 1999

Arch. Environ. Contam. Toxicol.

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Metals are released into aquatic systems from many sources, often at sublethal concentrations. The effects of sublethal concentrations of metals on fish are not entirely understood. The objective of this study was to determine the hematological and biochemical effects of a range of copper concentrations (6.4, 16.0, 26.9 microg Cu/L) on rainbow trout (Oncorhynchus mykiss) over a prolonged period of time. Trout were exposed to copper, and, at intervals of 3, 7, 14, and 21 days, selected parameters were evaluated. Hemoglobin, hematocrit, plasma glucose, and plasma cortisol levels were elevated in trout exposed to 26.9 microg Cu/L at day 3 and then returned to levels comparable to control fish. Plasma protein and lactate levels were not significantly altered in trout from any copper treatment. Hepatic copper concentration and hepatic metallothionein mRNA expression were consistently elevated in trout exposed to 26.9 microg Cu/L. Both of these parameters stabilized by day 3, with only hepatic copper concentration showing a further increase at day 21. Hepatic copper concentration and hepatic metallothionein mRNA expression appear to be robust indicators of copper exposure. Most blood-based parameters evaluated appear to be associated with a transitory, nonspecific stress response. The return of elevated hematological and biochemical parameters to control levels after 3 days and the stabilization of hepatic metallothionein mRNA expression and copper concentration over a similar time period suggested acclimation to dissolved copper at 26.9 microg/L. Further analysis of the data on blood-based parameters indicated that certain parameters (hemoglobin, hematocrit, plasma glucose, plasma cortisol) may be useful in field monitoring.

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Section: Hepatic Copper and Metallothioneinsupporting

confidence: 54%

The Effects of Copper on Blood and Biochemical Parameters of Rainbow Trout (Oncorhynchus mykiss)

Dethloff¹,

Schlenk²,

Khan³

et al. 1999

Arch. Environ. Contam. Toxicol.

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“…Moreover, Lundebye et al (1999) suggested that decreased growth in Atlantic salmon was due to increased metabolic costs of intestinal cellular changes and Cu excretion. The reduced growth produced by Cu was attributed to metabolic costs associated with metal detoxification (Marr et al, 1996). The aforementioned findings lend a considerable support to the present findings.…”

Section: Discussionsupporting

confidence: 89%

Toxicity bioassay of lead acetate and effects of its sub-lethal exposure on growth, haematological parameters and reproduction in Clarias gariepinus

Hmoud¹,

Ahmad²,

Ali³

et al. 2011

Afr. J. Biotechnol.

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The African catfish, Clarias gariepinus, was exposed to different concentrations of lead acetate for 96 h, and the value of LC 50 for the exposure period was registered as 122 mg/L. The effects of sub-lethal exposure on growth, reproduction and haematological parameters were also investigated in C. gariepinus. Lead exposure at all concentrations reduced growth rate, and was inversely related to growth. There were significant effects of lead exposure on erythrocyte count, haemoglobin concentration and haematocrit values. Lead exposure time and dose increased the plasma glutamicoxaloacetic transaminase (PGOT) and plasma glutamic-pyruvic transaminase (PGPT) activity levels. No significant effect of lead acetate was noticed on fecundity and ovum size. Sperm motility was reduced in all concentrations of lead acetate after 4 weeks of exposure. The present investigation indicates that the lead acetate is less toxic to fish than other metals as the LC 50 value is comparatively high.

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“…The authors suggested that this effect was due to Cu-exposed fish expending more energy to sustain normal metabolism, leaving less energy available for growth (De Boeck et al, 1997). The physiological changes that permit metal detoxification and homeostasis incur energetic costs, and reduced growth due to Cu exposure is likely caused by these metabolic costs associated with metal detoxification (Marr et al, 1996). In the case of olive flounder, decreased growth rates were likely due to increased energy expenditure for sustaining normal metabolism against Cu detoxification, depleting the energy available for growth.…”

Section: Copper Eliminationmentioning

confidence: 99%

“…Moreover, tissue-specific accumulation of metals may be a key indicator of chronic exposure (Bergman and Dorward-King, 1997). Although the subchronic toxic effects of Cu on fish are well documented, studies have primarily focused on freshwater fish (Pelgrom et al, 1995;Marr et al, 1996;De Boeck et al, 1997;Mazon and Femandes, 1999;McGeer et al, 2000a), whereas few studies have examined the effects of Cu on marine fishes. Therefore, the kinetics of Cu accumulation in fish tissues are of great importance, particularly for marine fish.…”

Section: Introductionmentioning

confidence: 99%

Cu Accumulation and Elimination in the Tissues of the Olive Flounder Paralichthys olivaceus

Kim¹,

Jang²,

Lee³

et al. 2011

Fisheries and aquatic sciences

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Olive flounder, Paralichthys olivaceus were exposed to waterborne Cu (control, 50, 80, 150, and 320 µg/L) for 30 days and then depurated for 20 days to investigate the effects of waterborne Cu exposure on growth, accumulation, and elimination. The weightspecific growth rate was significantly negatively related to waterborne Cu concentrations at 150 and 320 µg/L. The order of Cu accumulation in different tissues of exposed fish was liver>intestines>gills>kidneys>muscle, suggesting that the liver is more important than other tissues for the storage of Cu in olive flounder. The accumulation factor for the gills, intestines, liver, and muscle increased with increasing exposure time, and accumulation was negatively related to exposure concentration for the gills, kidneys, and muscle. Cu concentrations in the gills, intestines, and liver continuously decreased for 20 days of depuration. The fastest elimination rate occurred in the intestines at all exposure concentrations, and the order of Cu elimination in the different tissues was intestines>liver>gills.

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Relationship between copper exposure duration, tissue copper concentration, and rainbow trout growth

Cited by 91 publications

References 24 publications

The Effects of Copper on Blood and Biochemical Parameters of Rainbow Trout (Oncorhynchus mykiss)

The Effects of Copper on Blood and Biochemical Parameters of Rainbow Trout (Oncorhynchus mykiss)

Toxicity bioassay of lead acetate and effects of its sub-lethal exposure on growth, haematological parameters and reproduction in Clarias gariepinus

Cu Accumulation and Elimination in the Tissues of the Olive Flounder Paralichthys olivaceus

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