Relationship between Diet, Microbiota, and Healthy Aging

Sanchez-Morate, Elisa; Gimeno-Mallench, Lucía; Stromsnes, Kristine; Sanz-Ros, Jorge; Román-Domínguez, Aurora; Parejo-Pedrajas, Sergi; Inglés, Marta; Òlaso, Gloria; Gambini, Juan; Mas-Bargues, Cristina

doi:10.3390/biomedicines8080287

Cited by 33 publications

(23 citation statements)

References 99 publications

(116 reference statements)

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“…The microbiota can modulate changes in aging related to innate immunity, sarcopenia, and cognitive function, which are essential components of the frailty syndrome through nutrition we can modify the microbiota to maintain intestinal health by stimulating beneficial bacteria [ 31 ]. In a parallel 8-week randomized controlled trial, 82 overweight and obese subjects without underlying diseases were separated into two groups.…”

Section: Diet and Inflammationmentioning

confidence: 99%

Anti-Inflammatory Properties of Diet: Role in Healthy Aging

et al. 2021

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Inflammation is a physiological process involved in the defenses of the body and the repair of tissues. It is acutely activated by infections, trauma, toxins, or allergic reactions. However, if it becomes chronic, inflammation can end up stimulating the development of diseases such as cardiovascular disease, autoimmune disease, neurological disease, or cancer. Additionally, during aging, inflammation becomes increasingly more chronic. Furthermore, we found that certain foods, such as saturated fats, have pro-inflammatory activity. Taking this into account, in this review we have discussed different diets with possible anti-inflammatory activity, the commonly ingested components of each diet and their active compounds. In addition, we have proposed some dietary guidelines, as well as a list of compounds present in foods with anti-inflammatory activity, outlining how to combine them to achieve optimal anti-inflammatory effects. Therefore, we can conclude that the compounds in our diet with anti-inflammatory activity could help alleviate the inflammatory processes derived from diseases and unhealthy diets, and thereby promote healthy aging.

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Section: Diet and Inflammationmentioning

confidence: 99%

Anti-Inflammatory Properties of Diet: Role in Healthy Aging

et al. 2021

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“…Clinical and microbiological studies focused on the importance of species diversity for improving microbial community resilience, even considering that each individual tends to develop a specific microbial profile [ 9 ]. These profiles tend to be stable over time, even if they may be altered at any time by drugs, such as antibiotics [ 10 ] or lifestyle choices, including diet, physical activity, and smoking [ 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Cigarette Smoking and Human Gut Microbiota in Healthy Adults: A Systematic Review

et al. 2022

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The intestinal microbiota is a crucial regulator of human health and disease because of its interactions with the immune system. Tobacco smoke also influences the human ecosystem with implications for disease development. This systematic review aims to analyze the available evidence, until June 2021, on the relationship between traditional and/or electronic cigarette smoking and intestinal microbiota in healthy human adults. Of the 2645 articles published in PubMed, Scopus, and Web of Science, 13 were included in the review. Despite differences in design, quality, and participants’ characteristics, most of the studies reported a reduction in bacterial species diversity, and decreased variability indices in smokers’ fecal samples. At the phylum or genus level, the results are very mixed on bacterial abundance both in smokers and non-smokers with two exceptions. Prevotella spp. appears significantly increased in smokers and former smokers but not in electronic cigarette users, while Proteobacteria showed a progressive increase in Desulfovibrio with the number of pack-years of cigarette (p = 0.001) and an increase in Alphaproteobacteria (p = 0.04) in current versus never smokers. This attempt to systematically characterize the effects of tobacco smoking on the composition of gut microbiota gives new perspectives on future research in smoking cessation and on a new possible use of probiotics to contrast smoke-related dysbiosis.

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“…Last but not least, it is suggested that age-related gut microbiota dysbiosis can trigger the innate immune response and chronic low-grade inflammation, leading to frailty and unhealthy aging [ 53 , 54 ]. A diverse diet was reported to promote a healthier gut microbiota [ 55 ], which may further promote healthy aging [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Dietary Diversity and Healthy Aging: A Prospective Study

Zhang

Zhao

2021

Nutrients

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Population aging is a global phenomenon. The present study determined the effects of dietary diversity score (DDS) and food consumption on healthy aging. A subset of the data of the China Health and Nutrition Survey was utilized in this study. DDSs were calculated using the dietary data collected in the years 2009 and 2011. A healthy aging score (HAS) was calculated by summing the standardized scores on physical functional limitation, comorbidity, cognitive function, and psychological stress based on the data collected in the year 2015, with a lower HAS indicating a healthier aging process. Life quality was self-reported in the year 2015. This study found that DDS was inversely associated with HAS (T3 vs. T1: β −0.16, 95%CI −0.20 to −0.11, p-trend <0.001). The consumption of meat and poultry, aquatic products, and fruits was inversely associated with HAS, and participants in the highest tertile of staple foods consumption had a higher HAS than those in the lowest tertile. HAS was inversely associated with good self-reported life quality and positively associated with bad life quality. In conclusion, food consumption may influence the aging process, and adherence to a diverse diet is associated with a healthier aging process in elderly people.

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Relationship between Diet, Microbiota, and Healthy Aging

Cited by 33 publications

References 99 publications

Anti-Inflammatory Properties of Diet: Role in Healthy Aging

Anti-Inflammatory Properties of Diet: Role in Healthy Aging

Cigarette Smoking and Human Gut Microbiota in Healthy Adults: A Systematic Review

Dietary Diversity and Healthy Aging: A Prospective Study

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