Relationship Between Dietary Intake and Urinary Excretion of Silicon in Free-Living Korean Adult Men and Women

Kim, Yi-Yeong; Kim, Mi‐Hyun; Choi, Mi‐Kyeong

doi:10.1007/s12011-018-1619-0

Cited by 7 publications

(7 citation statements)

References 32 publications

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“…Fasting blood samples were also drawn from 126 consenting subjects on the day of the dietary interview, and plasma samples were collected for the measurement of silicon levels—exclusively using plastic ware to prevent pre-analysis silicon contamination of the samples. Subsequent analyses were performed for the whole population and for men and women separately, considering gender differences between silicon intake and silicon blood levels, as previously reported [9,11,14]. As the silicon level in the blood has been shown to be significantly influenced by age, and because differences in silicon intake might be age-related, according to previously published studies, we decided to analyze silicon intake and serum levels in age groups largely conforming to those applied by the National Food and Nutrition Institute (Warsaw, Poland) when reporting recommended daily intake values for trace elements in adults [15].…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Although the data on silicon content in foods are incomplete, it has been assumed that cereals, along with beverages (especially beer) and some vegetables and fruits, contribute the most to the dietary intake of silicon [10,11,12]. The higher daily silicon intake of men than women which has been reported by some authors has been attributed to the typically higher beer consumption among men [9,11]. The bioavailability of silicon differs between foods: orthosilicic acid and water-soluble silicates from beverages are easily absorbed, whereas phytolytic silica, present in solid plant foods, is less absorbable [9,10,13].…”

Section: Introductionmentioning

confidence: 99%

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Dietary Silicon and Its Impact on Plasma Silicon Levels in the Polish Population

2019

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Silicon in nutritional amounts provides benefits for bone health and cognitive function. The relationship between silicon intake from a common daily diet and silicon blood level has been scarcely elucidated, so far. The aim of this study was to analyze the associations between plasma silicon levels and the total and bioavailable silicon intake—along with the contribution of silicon made by food groups—in a healthy adult Polish population. Si intake was evaluated in 185 healthy adults (94 females and 91 males, aged 20–70) using a 3-day dietary recall and a database on the silicon content in foods, which was based on both previously published data and our own research. Fasting plasma silicon levels were measured in 126 consenting subjects, using graphite furnace atomic absorption spectrometry. The silicon intake in the Polish population differed significantly according to sex, amounting to 24.0 mg/day in women and 27.7 mg/day in men. The median plasma silicon level was 152.3 µg/L having no gender dependency but with a negative correlation with age. Significant correlations were found between plasma silicon level and total and bioavailable silicon intake, as well as water intake in the diet (r = 0.18, p = 0.044; r = 0.23, p = 0.011; r = 0.28, p = 0.002, respectively). Silicon intakes from non-alcoholic beverages, cereal foods, and carotene-rich vegetables were also positively associated with plasma silicon levels. These results may help establish dietary silicon recommendations and formulate practical advice on dietary choices to ensure an appropriate supply of silicon. The outcome of this study, however, needs to be confirmed by large-scale epidemiological investigations.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dietary Silicon and Its Impact on Plasma Silicon Levels in the Polish Population

2019

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“…One of the challenges in undertaking toxicokinetic studies of unlabeled SAS materials (i.e., via Si determination) is the high endogenous Si background in tissues and biological fluids. The Si background concentration depends on the Si amount ingested via the diet, which consists of naturally occurring soluble silicon (orthosilicic acid-OSA-and associated silicon-containing species with high bioavailability) and some polymeric or phytolithic silica in vegetable food (thought to be hydrolyzed to OSA in the GI tract) [39][40][41][42][43]. The elimination half-life of dietary silicon via urinary excretion is in the order of few hours depending on the source [44][45][46][47] highlighting that Si background, at least in fasting blood (and perhaps to a certain extent in some organs), can be limited if animals are acclimated to a non-high Si diet.…”

Section: Maintenance Dietmentioning

confidence: 99%

Determination of Total Silicon and SiO2 Particles Using an ICP-MS Based Analytical Platform for Toxicokinetic Studies of Synthetic Amorphous Silica

et al. 2020

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Synthetic amorphous silica (SAS), manufactured in pyrogenic or precipitated form, is a nanomaterial with a widespread use as food additive (E 551). Oral exposure to SAS results from its use in food and dietary supplements, pharmaceuticals and toothpaste. Recent evidence suggests that oral exposure to SAS may pose health risks and highlights the need to address the toxic potential of SAS as affected by the physicochemical characteristics of the different forms of SAS. For this aim, investigating SAS toxicokinetics is of crucial importance and an analytical strategy for such an undertaking is presented. The minimization of silicon background in tissues, control of contamination (including silicon release from equipment), high-throughput sample treatment, elimination of spectral interferences affecting inductively coupled plasma mass spectrometry (ICP-MS) silicon detection, and development of analytical quality control tools are the cornerstones of this strategy. A validated method combining sample digestion with silicon determination by reaction cell ICP-MS is presented. Silica particles are converted to soluble silicon by microwave dissolution with mixtures of HNO3, H2O2 and hydrofluoric acid (HF), whereas interference-free ICP-MS detection of total silicon is achieved by ion-molecule chemistry with limits of detection (LoDs) in the range 0.2–0.5 µg Si g−1 for most tissues. Deposition of particulate SiO2 in tissues is assessed by single particle ICP-MS.

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“…Whilst there are many Si compounds, the primary specie that humans can assimilate is the soluble orthosilicic acid (OSA), [Si(OH) 4 ] [11,12]. The dietary intake of Si in Western populations is 20-50 mg/day (0.7-1.8 mmol/day) [13][14][15]. The highest levels of Si are found in cereal-based products, whereas fruits and vegetables have highly variable levels [16] and animal-derived products are low in Si [13].…”

Section: Introductionmentioning

confidence: 99%

Urinary Excretion of Silicon in Men, Non-pregnant Women, and Pregnant Women: a Cross-sectional Study

Magnusson

Jugdaohsingh

Hulthén

et al. 2019

Biol Trace Elem Res

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Silicon is a trace element found mainly in plant-based food and proposed to be beneficial for bone health. Urinary excretion of Si has been shown to be a surrogate measure of its uptake in the gastrointestinal tract. The objective of this study was to describe and compare the levels of urinary Si excretion, and consequently Si uptake, in Swedish men, non-pregnant women, and pregnant women. No formal assessment of dietary Si intake was carried out in this study. This cross-sectional study included 89 men, 42 non-pregnant women, and 60 pregnant women. The subjects collected urine over a 24-h period and the samples were assayed for total Si using inductively coupled plasma optical emission spectrometry. The excretion levels of creatinine were used to validate the completeness of the urine sample collections. The mean 24-h urinary excretions of Si were 7.8 mg for the cohort of young men, 7.6 mg for the cohort of non-pregnant women, and 12.4 mg for the cohort of pregnant women. Creatinine excretion was similar between pregnant and non-pregnant women (10.4 vs. 10.8 mmol/day) and significantly higher in men (15.4 mmol/day). The pregnant women excreted significantly higher levels of Si than the young men and non-pregnant women, respectively (p < 0.05). The higher urinary excretion of Si by pregnant women compared with men and non-pregnant women is a novel finding possibly caused by temporary physiological changes during pregnancy such as increased gastrointestinal uptake of Si, altered bone metabolism, and increased renal excretion of Si.

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Relationship Between Dietary Intake and Urinary Excretion of Silicon in Free-Living Korean Adult Men and Women

Cited by 7 publications

References 32 publications

Dietary Silicon and Its Impact on Plasma Silicon Levels in the Polish Population

Dietary Silicon and Its Impact on Plasma Silicon Levels in the Polish Population

Determination of Total Silicon and SiO2 Particles Using an ICP-MS Based Analytical Platform for Toxicokinetic Studies of Synthetic Amorphous Silica

Urinary Excretion of Silicon in Men, Non-pregnant Women, and Pregnant Women: a Cross-sectional Study

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