Relationship between Exposure to Pesticides and Occurrence of Acute Leukemia in Iran

Zakerinia, Maryam; Sajad, Amirghofran; Namdari, Maral; Zahra, Lesan; Sima, Pooralimohamad; Zeinab, Attabac; Zahra, Mehravar; Fariba, Ebrahimi; Haghpanah, Sezaneh; Mehrabani, Davood

doi:10.7314/apjcp.2015.16.1.239

Cited by 24 publications

(11 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The high‐intensity use of organophosphate (OP) pesticides has contributed to morbidity and mortality in farmworkers and their families through acute or chronic pesticide‐related illnesses . Recently, the long‐term effects of pesticide exposure have been associated with many diseases . The Phytoner study reported an association between chronic exposure to pesticides and cognitive impairment .…”

Section: Introductionmentioning

confidence: 99%

Mechanism underlying the effect of long‐term exposure to low dose of pesticides on DNA integrity

Alleva

Manzella

Gaetani

et al. 2018

Environmental Toxicology

View full text Add to dashboard Cite

Pesticides, including herbicides, insecticides and fungicides, are widely used in intensive agriculture. Recently, the long-term effects of pesticide exposure were found to be associated with many diseases. In this study, we evaluated the long-term effect of low-level exposure to a mixture of pesticides on DNA damage response (DDR) in relation to individual detoxifying variability. A residential population chronically exposed to pesticides was enrolled, biological/environmental pesticide levels; paroxonase 1 (PON-1) activity and 192 Q/R polymorphism and DDR were evaluated at three different periods of pesticide exposure. OGG1-dependent DNA repair activity was decreased in relation to pesticide exposure. The increase of DNA lesions and pesticide levels in the intensive pesticide-spraying period was independent on PON-1 activity. Next, human bronchial epithelial and neuronal cells were used as a model for in vitro evaluation of the mechanistic effect of pesticides. Pesticides induced mitochondrial dysfunction leading to ROS formation. ROS from mitochondria induced DNA damage, which in turn induced OGG1-dependent DNA repair activity through 8-oxoguanine DNA glycosylase 1 (OGG1) expression and activation. Even though OGG1 was overexpressed, an inhibition of its activity, associated with DNA lesion accumulation, was found at prolonged pesticide-exposure. A post-translational regulation of OGG1 by pesticide may be postulated. Taken together, long-term exposure to low-levels of pesticides affects DDR resulting in accumulation of DNA lesions that eventually may lead to cancer or neurological disorders.

show abstract

Section: Introductionmentioning

confidence: 99%

Mechanism underlying the effect of long‐term exposure to low dose of pesticides on DNA integrity

Alleva

Manzella

Gaetani

et al. 2018

Environmental Toxicology

View full text Add to dashboard Cite

show abstract

“…The data according to the Food and Agriculture Organization of the United Nations (FAO) showed that the average use of pesticides per area of cropland (kg/ha) in each year in mainland China increased from 1990 to 2015. Pesticide exposure is a known risk factor of many diseases, such as cancer [8–14], asthma [15, 16], diabetes [17–19], Parkinson’s disease [20–22], leukemia [23, 24], mental diseases [25–28], and non-Hodgkin lymphoma [29] and may also be related to sleep disturbances. A case-control design study showed that increased tension, greater depression and fatigue, and more frequent symptoms of central nervous system disturbances were observed in pesticide-exposed women [30].…”

Section: Introductionmentioning

confidence: 99%

Relationship between cumulative exposure to pesticides and sleep disorders among greenhouse vegetable farmers

Hao

Tian

et al. 2019

BMC Public Health

View full text Add to dashboard Cite

Background In the northern region of China, many greenhouse vegetable farmers are exposed to high cumulative levels of pesticides due to long-term work in greenhouses that impacts their health. The aim of the current study was to identify the relationship between cumulative pesticide exposure and sleep disorders among farmers in Yinchuan, Northwest China. Methods A cross-sectional study was conducted for 3 consecutive years in 2015, 2016 and 2017. Using a random sampling to select the resident teams, 1366 participants were enrolled, and information was collected via face-to-face interviews by trained investigators. Ordinal logistic, multinomial logistic and poisson logistic regression models were used to identify the associations between cumulative exposure intensity (CEI) and sleep disorders. Results High CEI ( OR = 1.56, 95% CI : 1.02–3.38) was associated with short sleep duration when compared with low CEI in the Full Model. CEI was not associated with long sleep duration. Self-rated sleep quality was associated with medium ( OR = 1.46, 95% CI : 1.10–2.00) and high ( OR = 2.50, 95% CI : 1.83–3.40) CEI. Similarly, having difficulty sleeping was associated with medium ( OR = 1.52, 95% CI : 1.02–2.24) and high ( OR = 1.74, 95% CI : 1.16–2.62) CEI. Differences in the associations by gender were also noted. Conclusion CEI was associated with sleep disorders, and gender differences were observed. Efforts should be made by local governments to address sleep problems that result from cumulative pesticide exposure in farmers, and gender differences should be considered. Electronic supplementary material The online version of this article (10.1186/s12889-019-6712-6) contains supplementary material, which is available to authorized users.

show abstract

“…The incidence of leukemia in men was nearly twice as much as women (6.82 vs. 3.49 per 100,000). The main reason was that men were more exposed to risk factors such as; smoking and occupational and environmental hazards like chemical agents, pesticides and radiation [ 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Changing Epidemiology of Common Cancers in Southern Iran, 2007-2010: A Cross Sectional Study

et al. 2016

View full text Add to dashboard Cite

We have evaluated the ever changing epidemiology of cancers in Fars province, Iran since the re-establishment of Fars cancer registry. Based on the collected data from all related sources in Fars province from 2007–2010 we calculated the cancer age-standardized rates per 100,000 person-years (ASRs). The results are presented as incidence rates of cases by site according to the International Classification of Diseases for Oncology (ICD-O), sex, age, crude rate, and ASRs. In women the total ASR was 41.70 per 100,000 from 1985–1989 which had increased to 55.50 and 95.46 during 1998–2002 and 2007–2010. The incidence of breast cancer in women during 2007–2010 was about two and four times higher than 1998–2002 and 1985–1989. The incidence of colorectal cancer in women during 2007–2010 was about three and five times higher than 1998–2002 and 1985–1989. In men the total ASR was 62.9 per 100,000 in 1985–1989 that increased to 64.50 and 101.48 during 1998–2002 and 2007–2010. Although stomach cancer was the most common cancer among men during 1985–1989 and 1998–2002, but in recent study bladder cancer was the most common cancer among men in Fars province. The incidence of colorectal cancer in men during 2007–2010 was about three times higher than 1998–2002 and 1985–1989. This study shows growing incidence of cancer in southern Iran. The colorectal cancer in both genders had increased and its pattern is similar to western countries. In men, bladder and prostate cancers had a growing rate and the incidences of these cancers in the present study were greater than stomach cancer.

show abstract

Relationship between Exposure to Pesticides and Occurrence of Acute Leukemia in Iran

Cited by 24 publications

References 20 publications

Mechanism underlying the effect of long‐term exposure to low dose of pesticides on DNA integrity

Mechanism underlying the effect of long‐term exposure to low dose of pesticides on DNA integrity

Relationship between cumulative exposure to pesticides and sleep disorders among greenhouse vegetable farmers

Changing Epidemiology of Common Cancers in Southern Iran, 2007-2010: A Cross Sectional Study

Contact Info

Product

Resources

About