Relationship between expression of CXCR7 and NF-κB in breast cancer tissue and occurrence of breast cancer and lymphatic metastasis

Yuan, Chengliang; Zhao-hong, Liu; Zou, Ning; Wang, Yali; Chen, Zhong-yao

doi:10.1016/j.sjbs.2017.11.009

Cited by 1 publication

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“…The metastatic potential of breast cancer depends on the expression of many proteins on membrane surface, or some compounds in extracellular matrix, such as matrix metalloproteinases (MMPs), plasminogen activator (PA), or nitric oxide synthase (NOS) (Cvetković et al 2017a, b). Clear understanding of the mechanism of invasion and metastasis processes in breast cancer patients, such as CXCL-12, VEGF, HIF-1, MMP-9 and iNOS, has significant importance in oncological treatment (Yuan et al 2017). Triple-negative, breast MDA-MB-231 cancer cell line is obtained from pleural effusion of breast cancer patients with metastatic disease.…”

Section: Introductionmentioning

confidence: 99%

The anti-invasive activity of Robinia pseudoacacia L. and Amorpha fruticosa L. on breast cancer MDA-MB-231 cell line

et al. 2019

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The paper investigates anticancer effects of methanol extracts of invasive plant species Robinia pseudoacacia L. (RpE) and Amorpha fruticosa L. (AfE) on breast cancer MDA-MB-231 and healthy MRC-5 cells. The anticancer activity was evaluated through examination of cytotoxic effects, anti-invasive potential and impact on redox status in comparative analysis using their chemical composition. According to the IC 50 values, the investigated plants had no significant cytotoxic effects either on healthy cell line MRC-5 or on MDA-MB-231 cancer cells, but they showed great anti-invasive potential by suppressing all investigated parameters of tumor invasion and metastases (Matrix Metalloproteinases (MMP), protein concentration and MMP-9, C-X-C Motif Chemokine Ligand 12 (CXCL-12), Vascular Endothelial Growth Factor (VEGF-A) and Hypoxia-Inducible Factor (HIF-1α) gene expression) in MDA-MB-231 cells. Based on their remarkable anti-invasive potential, RpE and AfE are suitable for use as potential supplements in anticancer therapy or as nutritional food supplements.

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Section: Introductionmentioning

confidence: 99%

The anti-invasive activity of Robinia pseudoacacia L. and Amorpha fruticosa L. on breast cancer MDA-MB-231 cell line

et al. 2019

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Relationship between expression of CXCR7 and NF-κB in breast cancer tissue and occurrence of breast cancer and lymphatic metastasis

Abstract: both CXCR7 and NF-κB are related to the malignant grade of the breast cancer and lymphatic metastasis, which may be regarded as in important indicator to judge the prognosis of the breast cancer and be expected to be the new target of curing part of the breast cancer.

Cited by 1 publication

References 9 publications

The anti-invasive activity of Robinia pseudoacacia L. and Amorpha fruticosa L. on breast cancer MDA-MB-231 cell line

The anti-invasive activity of Robinia pseudoacacia L. and Amorpha fruticosa L. on breast cancer MDA-MB-231 cell line

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