Background: People with schizophrenia require long-term care and treatment. The high cost of treatment for sufferers makes many families decide to do their treatment at home. Government programs and policies such as Community Mental Health Nursing (CMHN) are one of the hopes of families to help them. Changes in the situation due to caring for people with schizophrenia need to be balanced with psychological adaptation by family members so that family acceptance characterizes an adaptive response. Objective: This article will provide information about factors related to family acceptance. Methods: This research used the systematic review method by utilizing eight electronic databases such as Scopus, DOAJ, ProQuest, Web of Science, ScienceDirect, PubMed, and SAGE from January 2012 to 2022. Articles obtained from electronic databases are related to relevant topics in a total of 79 articles, displaying only 20 articles analyzed that meet the criteria. The keywords used are "family acceptance" and "schizophrenia", "schizophrenia OR family OR acceptance". Results: Acceptance is an essential aspect of the family's psychological adaptation journey. Acceptance is related to a person's ability to face and undergo situations that are presented to him voluntarily. Stigma can reduce family confidence in caring for sufferers, thus requiring expectations, attitudes, experiences, social support, and convenience in health services. Conclusions: Other efforts are needed, apart from the sufferer's family, but also the support of other people and the community. In addition, health professionals like physicians or nurses are needed as role models not to discriminate against and stigmatize families and sufferers.