Relationship between fluorescence of polynuclear aromatic hydrocarbons in complex environmental mixtures and sample mutagenicity

Litten, Simon; Babish, John G.; Pastel, Michael J.; Werner, Mary B.; Johnson, B.

doi:10.1007/bf01608566

Cited by 4 publications

(1 citation statement)

References 7 publications

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“…Mutagenicity assessments of contaminated sediments and sludges have also been conducted, including studies by Babish et al [22], Sat0 et al [23], Hopke et al [%I, Litten et al. [25] and DeVoe and Voll 1261.…”

Section: Introductionmentioning

confidence: 99%

In Situ Variations in Oyster Mutagenicity and Tissue Concentrations of Polycyclic Aromatic Hydrocarbons*

Pittinger¹,

Buikema²,

Falkinham³

1987

Environ Toxicol Chem

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Variations in oyster mutagenicity were monitored in a series of in situ relocation experiments and compared with tissue concentrations of polycyclic aromatic hydrocarbons (PAHs). Oysters (Crassostrea virginica) were relocated among three rivers in the southern Chesapeake Bay and sampled over a 2-week exposure period. Extracts of oyster tissues were assayed for mutagenic activity by the Salmonella typhimurium microsomal test and analyzed for selected PAHs by gas chromatography. Oysters relocated to the polluted Elizabeth River (Norfolk, VA) from a pristine site (Ware River, VA) accumulated mutagenic activity and PAHs within 3 d following relocation. Mutagenicity increased over a 14-d period while tissue levels of most PAHs stabilized or declined after 3 d. Extracts of native oysters from the Elizabeth River exhibited comparable levels of mutagenic activity as 14-d relocated oysters. In elimination experiments, PAH levels and mutagenic activity of Elizabeth River oysters decreased following relocation to the Ware River and were not detected after 14 d. Regression analyses did not detect a significant association between slopes of mutagenicity dose-responses and tissue levels of PAHs. Marginal associations with numbers of Salmonella revertants per plate were detected in comparisons with sums of PAH tissue levels, and with tissue levels of benzofluoranthene.

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Section: Introductionmentioning

confidence: 99%

In Situ Variations in Oyster Mutagenicity and Tissue Concentrations of Polycyclic Aromatic Hydrocarbons*

Pittinger¹,

Buikema²,

Falkinham³

1987

Environ Toxicol Chem

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show abstract

In situ variations in oyster mutagenicity and tissue concentrations of polycyclic aromatic hydrocarbons

Pittinger

Buikema

Falkinham

1987

Enviro Toxic and Chemistry

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Variations in oyster mutagenicity were monitored in a series of in situ relocation experiments and compared with tissue concentrations of polycyclic aromatic hydrocarbons (PAHs). Oysters (Crassostrea virginica) were relocated among three rivers in the southern Chesapeake Bay and sampled over a 2‐week exposure period. Extracts of oyster tissues were assayed for mutagenic activity by the Salmonella typhimurium microsomal test and analyzed for selected PAHs by gas chromatography. Oysters relocated to the polluted Elizabeth River (Norfolk, VA) from a pristine site (Ware River, VA) accumulated mutagenic activity and PAHs within 3 d following relocation. Mutagenicity increased over a 14‐d period while tissue levels of most PAHs stabilized or declined after 3 d. Extracts of native oysters from the Elizabeth River exhibited comparable levels of mutagenic activity as 14‐d relocated oysters. In elimination experiments, PAH levels and mutagenic activity of Elizabeth River oysters decreased following relocation to the Ware River and were not detected after 14 d. Regression analyses did not detect a significant association between slopes of mutagenicity dose‐responses and tissue levels of PAHs. Marginal associations with numbers of Salmonella revertants per plate were detected in comparisons with sums of PAH tissue levels, and with tissue levels of benzofluoranthene.

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Petroleum hydrocarbons in the surface water of two estuaries in the Southeastern united states

Bidleman

Castleberry

Foreman

et al. 1990

Estuarine, Coastal and Shelf Science

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Relationship between fluorescence of polynuclear aromatic hydrocarbons in complex environmental mixtures and sample mutagenicity

Cited by 4 publications

References 7 publications

In Situ Variations in Oyster Mutagenicity and Tissue Concentrations of Polycyclic Aromatic Hydrocarbons*

In Situ Variations in Oyster Mutagenicity and Tissue Concentrations of Polycyclic Aromatic Hydrocarbons*

In situ variations in oyster mutagenicity and tissue concentrations of polycyclic aromatic hydrocarbons

Petroleum hydrocarbons in the surface water of two estuaries in the Southeastern united states

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