Relationship between Genetic Polymorphisms with Periodontitis and Peri-Implantitis in the Iranian Population: A Literature Review

Kadkhodazadeh, Mahdi; Tabari, Zahra Alizadeh; Pourseyediyan, Tahere; Najafi, Kimya; Amid, Reza

doi:10.1615/jlongtermeffmedimplants.2016015197

Cited by 6 publications

(10 citation statements)

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“…Different from mucositis, peri-implantitis is an irreversible inflammatory process that affects not only soft tissues but also surrounding supporting bone of implants in occlusal function (7,10,16,17). In fact, dental implant failure is a multifactorial condition, in which genetic polymorphisms can affect levels of gene expression and production or protein functions; as a consequence, they may influence the secretion of inflammatory cytokines and regulate the inflammatory responses and the susceptibility to the disease.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, dental implant failure is a multifactorial condition, in which genetic polymorphisms can affect levels of gene expression and production or protein functions; as a consequence, they may influence the secretion of inflammatory cytokines and regulate the inflammatory responses and the susceptibility to the disease. The RANK/RANKL/OPG system has a significant role in the production and activation of osteoclasts, and therefore in the regulation of bone resorption, possibly affecting the progression of periimplantitis (17,18). Previous studies evaluated the association between genetic polymorphisms with peri-implantitis in different populations (20)(21)(22)(23)(24)(25).…”

Section: Discussionmentioning

confidence: 99%

“…A recent systematic review (16) in different populations demonstrated that genetic polymorphisms in genes from the tumor necrosis factor superfamily, including: RANK (kappa β Nuclear Factor Receptor Activator), RANKL (kappa β Nuclear Factor Receptor Binding) and OPG (osteprogesterin), are candidate genes for peri-implant disease (14). Nevertheless, the authors pointed out that the results may vary according to the ethnic origin of the population studied (14,17,18), reinforcing the necessity of more studies evaluating genetic polymorphisms involved in peri-implant diseases in different populations. Therefore, the present study evaluated polymorphisms in RANK, RANKL and OPGencoding genes to assess whether they are associated with mucositis and peri-implantitis in a population from the Brazilian Amazon region.…”

Section: Introductionmentioning

confidence: 99%

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Association between Genetic Polymorphisms in RANK, RANKL and OPG and Peri-Implant Diseases in Patients from the Amazon Region

Silva¹,

Reis

Arid

et al. 2020

Braz. Dent. J.

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The present study evaluated polymorphisms in RANK, RANKL and OPG-encoding genes to assess whether they are associated with mucositis and peri-implantitis in a population from the Brazilian Amazon region. One hundred and fourteen patients with dental implants were included in the study. After clinical and radiographic examination, the sample was categorized into 4 groups, according to the peri-implant status: Healthy (n=71), Mucositis (n=30), Peri-implantitis (n=13) and Diseased (Mucositis + Peri-implantitis, n=43). Genomic DNA was extracted from buccal cells from saliva, and the genetic polymorphism in osteoprotegerin (OPG), Kappa nuclear factor activator receptor (RANKL) and nuclear kappa factor activator receptor (RANK) were genotyped by the real time PCR. Univariate and multivariate statistical analyses were performed to compare clinical variables among groups and to evaluate genotypes and alleles distributions and the established alpha was 5%. Age, peri-implant biotype, diabetes and presence of peri-implant biofilm were associated with mucositis (p<0.05) and peri-implantitis (p<0.05). Smoking, alcoholism, and periodontal biofilms were also associated with the presence of peri-implantitis (p<0.05). Univariate and multivariate analysis did not demonstrate an association of peri-implantitis or mucositis with any genetic polymorphism in RANK (rs3826620), RANKL (rs9594738) and OPG (rs2073618) (p>0.05). The studied genetic polymorphism in RANK, RANKL and OPG were not associated with mucositis and peri-implantitis in a Brazilian population from the Amazon region.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between Genetic Polymorphisms in RANK, RANKL and OPG and Peri-Implant Diseases in Patients from the Amazon Region

Silva¹,

Reis

Arid

et al. 2020

Braz. Dent. J.

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“…Genetic susceptibility has been shown to be a significant risk factor for peri-implantitis, and there are numerous studies assessing this in different populations [ 9 , 10 , 11 ]. Gene polymorphisms refer to changes in DNA sequencing, such as the regulation of inflammatory mediators, primarily the gene promoter region, which can affect gene function and the progression of inflammatory diseases [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Association of IL-10 and TNF-α Polymorphisms with Dental Peri-Implant Disease Risk: A Meta-Analysis, Meta-Regression, and Trial Sequential Analysis

Jamshidy

Tadakamadla

Choubsaz

et al. 2021

IJERPH

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Genetic susceptibility has been reported to be an important risk factor for peri-implant disease (PID). The aim of this meta-analysis was to assess the association between TNF-α and IL-10 polymorphisms and PID susceptibility. The Web of Science, Cochrane Library, Scopus, and PubMed/Medline databases were searched for studies published until 12 April 2021. RevMan 5.3, CMA 2.0, SPSS 22.0, and trial sequential analysis software were used. Twelve studies were included in our analysis. The pooled ORs for the association of TNF-α (−308 G > A), IL-10 (−1082 A > G), IL-10 (−819 C > T), and IL-10 (−592 A > C) polymorphisms were 1.12, 0.93, 1.35, and 0.77 for allelic; 1.42, 0.95, 3.41, and 0.34 for homozygous; 1.19, 1.88, 1.23, and 0.49 for heterozygous, 1.53, 1.12, 1.41, and 0.39 for recessive; and 1.16, 1.87, 2.65, and 0.75 for dominant models, respectively, with all the estimates being insignificant. The results showed an association between TNF-α (−308 G > A) polymorphism and the risk of PID in patients of Asian ethnicity (OR = 1.59; p = 0.03). The present meta-analysis illustrated that TNF-α (−308 G > A), IL-10 (−1082 A > G), IL-10 (−819 C > T), and IL-10 (−592 A > C) polymorphisms were not associated with the risk of PID, whereas TNF-α (−308 G > A) polymorphism was associated with an elevated risk of PID in Asian patients.

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“… 5 In addition, recent studies have demonstrated that genetic polymorphism is a major contributor to PI. 6 …”

Section: Introductionmentioning

confidence: 99%

Interleukin-16 rs4072111 Polymorphism is Associated with the Risk of Peri-Implantitis in the Chinese Population

Chen¹,

Chen²

2021

PGPM

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Purpose Peri-implantitis (PI) is a major contributor to dental implant failure. Genetic predisposition plays an essential role in the development of PI. The purpose of this study was to investigate the correlation of IL-16 gene single nucleotide polymorphisms (SNPs), rs11556218 and rs4072111, with PI at the gene level. Patients and Methods A total of 162 patients with PI and 162 cases with healthy implants were recruited as the case and control groups, respectively. The genotypes were analysed using direct sequencing. The genotype and allele proportion between the case and control groups were compared using the chi-square test. The periodontal status of patients carrying different genotypes was analysed, including gingival index, plaque index, calculus index, peri-implant pocket depth (PPD), and clinical attachment level (CAL). Results The case and control groups were age- and gender-matched. In the case group, the rs4072111 CT genotype was majorly observed, and the T allele carriers showed a high PI risk. Patients with the rs4072111 CT genotype had worse periodontal status, which was reflected by the higher levels of the gingival index, plaque index, calculus index, PPD and CAL. The distribution of the rs11556218 genotype and T allele showed no significant difference between the case and control groups ( P > 0.05). Conclusion The CT genotype of IL-16 gene rs4072111 SNP can be used as a factor assessing PI risk. Therefore, IL-16 genetic variation may be related to PI susceptibility in the Chinese Han population.

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Relationship between Genetic Polymorphisms with Periodontitis and Peri-Implantitis in the Iranian Population: A Literature Review

Cited by 6 publications

References 0 publications

Association between Genetic Polymorphisms in RANK, RANKL and OPG and Peri-Implant Diseases in Patients from the Amazon Region

Association between Genetic Polymorphisms in RANK, RANKL and OPG and Peri-Implant Diseases in Patients from the Amazon Region

Association of IL-10 and TNF-α Polymorphisms with Dental Peri-Implant Disease Risk: A Meta-Analysis, Meta-Regression, and Trial Sequential Analysis

Interleukin-16 rs4072111 Polymorphism is Associated with the Risk of Peri-Implantitis in the Chinese Population

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