Relationship between gonadotrophin secretion, inhibin B and spermatogenesis in oligozoospermic men treated with highly purified urinary follicle-stimulating hormone (uFSH-HP): a preliminary report

Fernández-Arjona, Manuel; Díaz, José Carlos Losada; Cortés, Ignacio; González, Jorge Hernández; Rodríguez, José María Rodríguez; Alvarez, Enríque

doi:10.1016/s0301-2115(02)00313-5

Cited by 13 publications

(6 citation statements)

References 16 publications

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“…On the contrary, the administration of rhFSH 100 IU induced a significant improvement of sperm concentration [ 17 ]. These results are supported by several studies in the literature which state that hpFSH is effective in improving sperm concentration when given at a weekly cumulative dose <450 IU, e.g., 75 IU every other day or 150 IU three times a week [ 7 , 10 , 18 , 19 ]. Very recently, we published a meta-analysis of randomized controlled studies to evaluate FSH dosage-effect on conventional sperm parameters.…”

Section: Discussionsupporting

confidence: 75%

Follicle-Stimulating Hormone Treatment and Male Idiopathic Infertility: Effects on Sperm Parameters and Oxidative Stress Indices according to FSHR c. 2039 A/G and c. -29 G/A Genotypes

Mongioì

Condorelli

Alamo

et al. 2020

JCM

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Scientific evidence shows that the administration of follicle-stimulating hormone (FSH) to infertile patients with normal serum FSH concentrations improves sperm parameters in oligozoospermic men. The aim of this study was to evaluate the effects of highly purified urofollitropin (hpFSH) on conventional and bio-functional sperm parameters and on oxidative stress indices in patients with idiopathic infertility. We also evaluated the response to hpFSH on these parameters in relationship to FSHR c. 2039 A/G and FSHR c. -29 G/A genotypes. A prospective longitudinal study was conducted on 42 patients with idiopathic male infertility, 23 of whom underwent to FSHR c. 2039 A/G and FSHR c. -29 G/A genotyping. Each patient was asked to collect two semen samples before and after administration of 150 IU hpFSH three times a week for 16 weeks. Patients were divided into responders or non-responders based on whether their total sperm count had at least doubled or was less than double at the end of treatment, respectively. Responders showed a significantly higher semen volume, sperm concentration, spermatids, and leukocytes. Non-responders had a significant decrease of the percentage of spermatozoa in early apoptosis after hpFSH administration. Oxidative stress indexes did not differ significantly after FSH administration in both groups. Conventional and bio-functional sperm parameters did not differ in patients with FSHR c. 2039 GG and AA genotypes, and FSHR c. -29 GG genotype both before and after FSH administration. The FSHR c. 2039 and FSHR -29 G/A genotypes and allelic distribution did not differ between responders and non-responders. FSH showed to be capable of ameliorating sperm parameters in about half patients treated, therefore it may be helpful in patients with idiopathic infertility.

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Section: Discussionsupporting

confidence: 75%

Follicle-Stimulating Hormone Treatment and Male Idiopathic Infertility: Effects on Sperm Parameters and Oxidative Stress Indices according to FSHR c. 2039 A/G and c. -29 G/A Genotypes

Mongioì

Condorelli

Alamo

et al. 2020

JCM

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“…As different studies used different doses of rhFSH, treated for different periods, studied different populations, the efficacy of FSH in the treatment of patients with oligozoospermia so far are still controversial. [13][14][15] At present, the exact mechanisms how FSH regulates the spermatogenesis are not very clear. Testes are composed largely of seminiferous tubules.…”

Section: Discussionmentioning

confidence: 99%

Treatment of idiopathic oligozoospermia with recombinant human follicle‐stimulating hormone: a prospective, randomized, double‐blind, placebo‐controlled clinical study in Chinese population

Ding¹,

Zhang

et al. 2015

Clinical Endocrinology

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“…The demonstrated biological effects of FSH treatment in male infertile patients are increased spermatogonial population and sperm count, [ 17 – 21 ], increased rate of fertilization, and increased pregnancy rate in programs of assisted fertilization [ 22 – 24 ]. However, several studies show a lack of effects of FSH on sperm parameters [ 25 – 27 ].…”

Section: Introductionmentioning

confidence: 99%

Reduced Seminal Concentration of CD45pos Cells after Follicle-Stimulating Hormone Treatment in Selected Patients with Idiopathic Oligoasthenoteratozoospermia

Condorelli

Calogero

Vicari

et al. 2014

International Journal of Endocrinology

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The present study evaluated the conventional sperm parameters and the seminal concentration of CD45pos cells (pan-leukocyte marker) of infertile patients with idiopathic oligoasthenoteratozoospermia (OAT). The patients were arbitrarily divided into three groups treated with recombinant follicle-stimulating hormone FSH: α (Group A = 20 patients), recombinant FSH-β (Group B = 20 patients), and highly purified human FSH (Group C = 14 patients). All treated groups achieved a similar improvement of the main sperm parameters (density, progressive motility, and morphology), but only the increase in the percentage of spermatozoa with normal morphology was significant compared to the baseline in all three examined groups. Moreover, all groups had a significant reduction of the seminal concentration of CD45pos cells and of the percentage of immature germ cells. Before and after the treatment, the concentration of CD45pos cells showed a positive linear correlation with the percentage of immature germ cells and a negative correlation with the percentage of spermatozoa with regular morphology. These results demonstrate that treatment with FSH is effective in patients with idiopathic OAT and that there are no significant differences between the different preparations. The novelty of this study is in the significant reduction of the concentration of CD45pos cells observed after the treatment.

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Relationship between gonadotrophin secretion, inhibin B and spermatogenesis in oligozoospermic men treated with highly purified urinary follicle-stimulating hormone (uFSH-HP): a preliminary report

Cited by 13 publications

References 16 publications

Follicle-Stimulating Hormone Treatment and Male Idiopathic Infertility: Effects on Sperm Parameters and Oxidative Stress Indices according to FSHR c. 2039 A/G and c. -29 G/A Genotypes

Follicle-Stimulating Hormone Treatment and Male Idiopathic Infertility: Effects on Sperm Parameters and Oxidative Stress Indices according to FSHR c. 2039 A/G and c. -29 G/A Genotypes

Treatment of idiopathic oligozoospermia with recombinant human follicle‐stimulating hormone: a prospective, randomized, double‐blind, placebo‐controlled clinical study in Chinese population

Reduced Seminal Concentration of CD45pos Cells after Follicle-Stimulating Hormone Treatment in Selected Patients with Idiopathic Oligoasthenoteratozoospermia

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