Relationship Between GSTT1 Gene Polymorphism and Hepatocellular Carcinoma in Patients from China

Chen, Jie; Ma, Liang; Peng, Ning-Fu; Wang, Shijun; Li, Le‐Qun

doi:10.7314/apjcp.2012.13.9.4417

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…Studies have demonstrated that chronic HBV carriers with a family history of HCC have a two-fold risk for HCC over those without any family history (Yu et al, 2000), which suggested that genetic susceptibility for HBV-related HCC is a strong component of this disease. Furthermore, it is common knowledge that single nucleotide polymorphisms (SNPs) in immune response and tumorigenesis related genes, such as XPD, XRCC1,MDR1,EGF,TP53, and GSTT1 might affect the host immune response to virus infection as well as provide crucial genetic markers for determining the stages of HCC development (Chen et al, 2012;Guo et al, 2012;Ren et al, 2012;Li et al, 2012Li et al, , 2013Thongbai et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Relationship between HLA-DP gene polymorphisms and the risk of hepatocellular carcinoma: a meta-analysis

Zhang

Zheng

et al. 2015

Genet. Mol. Res.

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ABSTRACT. The association between the HLA-DP single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 and hepatocellular carcinoma (HCC) has been reported, but results have been inconclusive and controversial. Therefore, to investigate the relationship between these HLA-DP SNPs and HCC susceptibility, a meta-analysis of studies published before January 2014 was carried out using the PubMed and Google Scholar databases. Odds ratios (ORs) and 95% confidence intervals (CI) were calculated for HLA-DP alleles, and for co-dominant, dominant, and recessive genotype models of each SNP, based on fixed-or randomeffects models. A total of nine studies from six published articles were included. The association study between rs3077 and HCC susceptibility was performed in four independent comparisons that contained 1871 cases with hepatitis B virus (HBV)-related HCC and 3207 carriers with (2015) persistent HBV. Association between rs9277535 and HCC susceptibility was examined in five separate comparisons that contained 2017 cases and 3930 carriers. Our analysis indicated a significant association of rs3077 and rs9277535 with HCC susceptibility, suggesting that rs3077 might act beneficially against HCC susceptibility (A vs G: OR = 0.884, 95%CI = 0.803-0.973, P = 0.012; GA vs GG: OR = 0.842, 95%CI = 0.733-0.967, P = 0.015; AA+GA vs GG: OR = 0.848, 95%CI = 0.744-0.968, P = 0.014), and that rs9277535 might promote HCC susceptibility (AA vs GA: OR = 1.202, 95%CI = 1.011-1.428, P = 0.037). This study suggested that HLA-DP rs3077 and rs9277535 polymorphisms are associated with HCC susceptibility in the Asian population.

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Section: Introductionmentioning

confidence: 99%

Relationship between HLA-DP gene polymorphisms and the risk of hepatocellular carcinoma: a meta-analysis

Zhang

Zheng

et al. 2015

Genet. Mol. Res.

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“…The epidemiology of HCC exhibits two main patterns, one in North America and Western Europe and another in nonWestern countries, such as those in sub-Saharan Africa, central and Southeast Asia, and the Amazon basin [4][5][6]. In China, HCC is one of the most common cancer types, with an incidence rate of 53/100,000 per year and a death rate of 37-55/100,000 annually [6][7][8].…”

Section: Introductionmentioning

confidence: 98%

Genetic variations in the one-carbon metabolism pathway genes and susceptibility to hepatocellular carcinoma risk: a case–control study

Zhang

Liu²,

Han³

et al. 2014

Tumor Biol.

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Hepatocellular carcinoma (HCC) is the sixth common cancer and the third common cause of cancer mortality worldwide. However, the exact molecular mechanism of HCC remains uncertain. Many enzymes are involved in one-carbon metabolism (OCM), and single nucleotide polymorphisms (SNPs) in the corresponding genes may play a role in liver carcinogenesis. In this study, we enrolled 1500 HCC patients and 1500 cancer-free controls, which were frequency-matched by age, gender, and HBV infection status. Then eight SNPs from seven OCM genes (MTHFR, MTR, MTRR, FTHFD, GART, SHMT, and CBS) were evaluated. Results showed that six SNPs (MTHFR rs1801133, MTRR rs2287780, MTRR rs10380, FTHFD rs1127717, GART rs8971, and SHMT rs1979277) were significantly associated with HCC risk in Chinese population, with P values range from 2.26 × 10(-4) to 0.035). The most significant association was detected for GART rs8971. Compared with individuals with the TT genotype, the age- and sex-adjusted odds ratio (OR) for developing HCC was 1.44 (95% confidence interval (CI): 1.03-2.02) among those with the CC genotype and 1.30 (95% CI: 1.10-1.53) for those with CT genotype. Under the log-additive model, each additional copy of minor allele C was associated with a 1.28-fold increased risk of HCC (OR = 1.28, 95% CI: 1.12-1.45). These findings indicated that genetic variants in OCM genes might contribute to HCC susceptibility.

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The association of GSTT1 deletion polymorphism with lung cancer risk among Chinese population: evidence based on a cumulative meta-analysis

Wang¹,

Yang²,

Li³

2015

OTT

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ObjectivePrevious studies investigating the relationship between glutathione S-transferase T1 (GSTT1) gene deletion polymorphism and lung cancer risk among Chinese population produced inconsistent results. To obtain a precise conclusion, we performed this meta-analysis to evaluate the association between GSTT1 deletion polymorphism and lung cancer risk among Chinese population.MethodsThe databases of Medline/PubMed, Embase, Web of Science, Wanfang Med Online, and Chinese National Knowledge Infrastructure were searched. The strength of the association was assessed by odds ratio (OR) with 95% confidence intervals (95% CI).ResultsOverall, we found an increased lung cancer risk among subjects carrying GSTT1 null genotype compared with those carrying present genotype (OR =1.31, 95% CI: 1.12–1.52) on the basis of 20 studies with 3,351 cases and 4,683 controls. We also observed an increased risk of lung cancer among subjects carrying GSTT1 null genotype compared with those carrying present genotype in stratified analyses (OR =1.31, 95% CI: 1.11–1.55 for healthy subjects-based control; OR =2.29, 95% CI: 1.84–2.85 for squamous cell carcinoma and OR =1.47, 95% CI: 1.22–1.77 for adenocarcinoma, respectively).ConclusionThis meta-analysis suggested that GSTT1 deletion polymorphism might contribute to lung cancer risk among Chinese population.

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Relationship Between GSTT1 Gene Polymorphism and Hepatocellular Carcinoma in Patients from China

Cited by 3 publications

References 20 publications

Relationship between HLA-DP gene polymorphisms and the risk of hepatocellular carcinoma: a meta-analysis

Relationship between HLA-DP gene polymorphisms and the risk of hepatocellular carcinoma: a meta-analysis

Genetic variations in the one-carbon metabolism pathway genes and susceptibility to hepatocellular carcinoma risk: a case–control study

The association of GSTT1 deletion polymorphism with lung cancer risk among Chinese population: evidence based on a cumulative meta-analysis

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