Relationship between Helicobacter pylori Adenotonsillar Colonization and Frequency of Adenotonsillitis in Children

Güçlü, Oğuz; Akçalı, Alper; Şahin, Erkan Melih; Tekin, Kazım; Barutçu, Ozan; Otkun, Metin; Dereköy, Fevzi Sefa

doi:10.5152/balkanmedj.2013.8585

Cited by 11 publications

(6 citation statements)

References 13 publications

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“…Using the real-time PCR, Nartova et al (6) proved that 80% of adenotonsillar samples of patients with chronic tonsillitis and 82.75% of the adenotonsillar samples of patients with sleep apnea syndrome were H. pylori-positive. Guclu et al (13) found a low incidence of H. pylori colonization in adenotonsillar tissue (4.1% RUT-positive and 6.1% PCRpositive) and found no significant association between H. pylori colonization and adenotonsillitis and ATH leading to obstructive sleep apnea. Farhadi et al (15) found only 15% of PCR-positive adenoid samples regardless of age and gender in children with ATH and rhinosinusitis.…”

Section: Discussionmentioning

confidence: 98%

“…It is believed that tonsil and adenoid tissue may form a colonization reservoir or an H. pylori colony, which can cause stomach and nasopharyngeal infection and clinical consequences (7,(11)(12)(13). Other researchers discovered no evidence of its presence in the sites, and the third group of authors believes that this agent is only a transient organism in the sites (14,15).…”

Section: Introductionmentioning

confidence: 99%

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Helicobacter pylori Colonization in Patients with Adenotonsillar Hypertrophy: Study on Prevalence and Clinical Characteristics of Colonized Patients and Possible Association with Complications

Pourmousa

Varshoi

Nikkhah

et al. 2020

Arch Pediatr Infect Dis

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Background: Adenotonsillar hypertrophy (ATH) is a common problem in children that causes the obstruction of airways and other relevant complications. Helicobacter pylori (H. pylori) is considered one of the microbial causes of ATH development. Objectives: The study aimed to determine the H. pylori colonization in patients with adenotonsillar hypertrophy and assess the prevalence and clinical characteristics of colonized patients and possible association with complications. Methods: This study was carried out on 114 children with ATH referring to the Bouali Hospital of Sari from December 2017 to December 2018. Adenotonsillar samples were prepared from the right and left tonsils and adenoid of each patient. The Rapid Urease test (RUT) and nested-PCR were performed on the samples. Data analysis was performed with SPSS version 20 software. Results:The participants included 52 females and 62 males with a mean age of 7.19 ± 3.08 years. The RUT was positive for 59 participants: 26 in right tonsil, 31 in left tonsil, and two in adenoid samples. Helicobacter pylori was detected in the adenotonsillar tissue of 95 patients using nested-PCR. No significant association was found between the PCR results and gender (P = 0.123). Conclusions: This study approved the presence of H. pylori in the adenotonsillar tissue of children with ATH and highlighted the concept that the pharynx could be an extra gastric reservoir of H. pylori. However, we failed to prove an association between H. pylori adenotonsillar colonization with ATH and acute otitis media.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori Colonization in Patients with Adenotonsillar Hypertrophy: Study on Prevalence and Clinical Characteristics of Colonized Patients and Possible Association with Complications

Pourmousa

Varshoi

Nikkhah

et al. 2020

Arch Pediatr Infect Dis

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“… 42 Additionally, just two samples (2%) produced positive findings on the fast urease test, while Güçlü et al discovered no positive growth in culture. 43 According to Hwang et al, tonsillar tissue colonization with Helicobacter pylori was not found to be more common with chronic or recurring infections. 44 On a study done by Wu et al 2022 reported that the presence of Helicobacter pylori in patients with chronic tonsillitis was significantly higher than the control group of children.…”

Section: Discussionmentioning

confidence: 99%

“…According to Unver et al report of 57.9% positive CLO tests on samples taken from patients who underwent adenotonsillectomy, 41 and when checking for the presence of H. pylori using PCR, Cirak et al discovered 30% positive findings. [42][43][44][45][46] Vilarinho et al, on the other hand, discovered no positive results using PCR-DEIA assays. 42 Additionally, just two samples (2%) produced positive findings on the fast urease test, while Güçlü et al discovered no positive growth in culture.…”

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confidence: 99%

Possible Role of Helicobacter pylori in Ear Nose and Throat Diseases

Aref¹,

Bazeed²,

Nafady³

et al. 2023

IDR

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Background Helicobacter pylori is assumed to cause many gastric and extragastric diseases. We aimed to assess the possible association role of H. pylori in Otitis media with effusion (OME), nasal polyps and adenotonsillitis. Patients and Methods A total of 186 patients with various ear, nose and throat diseases were included. The study comprised 78 children with chronic adenotonsillitis, 43 children with nasal polyps and 65 children with OME. OME patients were assigned to two subgroups: those who have and those who did not have adenoid hyperplasia. Among the patients with bilateral nasal polyps, 20 individuals had recurrent nasal polyps and 23 had de novo nasal polyps. Patients who have chronic adenotonsillitis were divided into three groups: those with chronic tonsillitis and those who underwent tonsillitis, those with chronic adenoiditis and adenoidectomy was performed, and those with chronic adenotonsillitis and underwent adenotonsillectomy. In addition to examination of H. pylori antigen in stool samples of all included patients, real-time polymerase chain reaction (RT-PCR) for detection of H. pylori in the effusion fluid was performed, additionally, Giemsa stain was used for detection of H. pylori organism within the tissue samples when available. Results Frequency of H. pylori in effusion fluid was 28.6% in patients with OME and adenoid hyperplasia, while in those with OME it was only 17.4% with a p value of 0.2. Nasal polyp biopsies were positive in 13% patients of denovo, and 30% patients with recurrent nasal polyps, p=0.2. De novo nasal polyps were more prevalent in the positive stools than recurrent ones, p=0.7. All adenoid samples were negative for H. pylori , only two samples of tonsillar tissue (8.3%) were positive for H. pylori , and stool analysis was positive in 23 patients with chronic adenotonsillitis. Conclusion Lack of association between Helicobacter pylori and occurrence of OME, nasal polyposis or recurrent adenotonsillitis.

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“…Down to date, there has not been found a standard inspection method used in upper airway tissue. In addition, the results of a recent study report that in cases of tonsillitis, the prevalence of H. pylori in tonsillar tissue varies greatly, with ranges from 8.3% to 80% [20], [21], [22].…”

Section: Discussionmentioning

confidence: 99%

Overview of Helicobacter pylori Detection Using Rapid Urease Test and Giemsa Modification Staining in Chronic Tonsillitis Patients

Asyari

Azman

Novialdi

et al. 2020

Open Access Maced J Med Sci

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BACKGROUND: Helicobacter pylori (H. pylori) is a Gram-negative bacteria and has been known for its role in causing gastric infection aused diseases such as gastric ulcer. H. pylori also implied to play a role in chronic tonsillitis, but this theory remains controversial. Many researches have different and contradictory results due to difficulty to accurately detect H. pylori in tonsillar tissue. There is still no appropriate method that able to detect H. pylori in tonsil tissue. AIM: The aim of the study was to detect H. pylori colonization in chronic tonsillitis and understand some of the methods of examination that can be done to detect H. pylori in tonsillar tissue. METHODS: This study is a descriptive study conducted on 25 respondents. Each sample was taken from patients with chronic tonsillitis who underwent tonsillectomy. Then, the rapid urease test (RUT) and the Giemsa modification staining were carried out to determine the presence of H. pylori. RESULTS: There were 19 people (76%) positive and 6 people (24%) negative for H. pylori using RUT. On examination with Giemsa modification staining obtained 19 people (76%) positive and 6 people (24%) negative for H. pylori. CONCLUSION: H. pylori can be found in most of chronic tonsillitis. Combination RUT and Giemsa modification staining examination can be a good option in detecting H. pylori in chronic tonsillitis.

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Relationship between Helicobacter pylori Adenotonsillar Colonization and Frequency of Adenotonsillitis in Children

Cited by 11 publications

References 13 publications

Helicobacter pylori Colonization in Patients with Adenotonsillar Hypertrophy: Study on Prevalence and Clinical Characteristics of Colonized Patients and Possible Association with Complications

Helicobacter pylori Colonization in Patients with Adenotonsillar Hypertrophy: Study on Prevalence and Clinical Characteristics of Colonized Patients and Possible Association with Complications

Possible Role of Helicobacter pylori in Ear Nose and Throat Diseases

Overview of Helicobacter pylori Detection Using Rapid Urease Test and Giemsa Modification Staining in Chronic Tonsillitis Patients

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