Relationship between hepcidin and ferritin in haemodialysed patients

Sedlácková, Terezie; Ráček, Jaroslav; Rajdl, Daniel; Kielberger, Lukáš; Eiselt, J; Malanova, Lada; Babuška, Václav

doi:10.1007/s00508-013-0388-1

Cited by 5 publications

(2 citation statements)

References 23 publications

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“…However, we previously demonstrated that the serum hepcidin level can be exclusively associated with the ferritin level in patients on MHD in the absence of apparent inflammation and independent of the levels of inflammatory cytokines [27] . Several reports have confirmed these observations [28][29][30] . These data suggest that excessive iron storage or administration increases hepcidin levels and accelerates iron sequestration in most of the cells in the body ( fig.…”

Section: Host Factorssupporting

confidence: 70%

Iron Localization and Infectious Disease in Chronic Kidney Disease Patients

Nakanishi

Kuragano²,

Nanami³

et al. 2016

Am J Nephrol

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For patients on dialysis, infection is the second leading cause of mortality. Iron metabolism should be considered in the pathogenesis of infectious disease, as high local iron concentrations favor the growth of many microbes. This review is intended to provide information regarding iron metabolism and infection in chronic kidney disease (CKD) patients. There are 2 reasons these patients may be vulnerable to infection: (1) the excessive iron administered to treat renal anemia could be associated with impairments of the host's innate immune response, (2) CKD-associated inflammation could cause dysregulated iron metabolism. Pathogenic microorganisms can be categorized as extracellular or intracellular pathogens. The proliferation site may determine the degree of virulence. In cases of mainly extracellular microbial growth, the host's strategy of sequestering iron in cells may efficiently inhibit proliferation. However, the same strategy may favor the intracellular growth of microorganisms. The administration of excessive amounts of iron may modify iron localization by an increase in the hepcidin concentration. We conclude that there is a need for large multicenter randomized controlled trials to evaluate the long-term safety of different iron administration patterns that allow for a lower infection rate while still producing efficient erythropoiesis in CKD patients.

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Section: Host Factorssupporting

confidence: 70%

Iron Localization and Infectious Disease in Chronic Kidney Disease Patients

Nakanishi

Kuragano²,

Nanami³

et al. 2016

Am J Nephrol

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“…There was a poor correlation between hepcidin, ferritin and CRP in hemodialyzed patients. It can be concluded that the influence of inflammation on hepcidin levels in hemodialyzed patients is not important and other factors including its retention and high iron stores in end-stage renal disease also participate [23].…”

Section: Fig 2 Diagram Proposed For Assessing the Risk Of Anemia Inmentioning

confidence: 99%

The Content of Reticulocyte Hemoglobin and Serum Concentration of the Soluble Transferrin Receptor for Diagnostics of Anemia in Chronically Hemodialyzed Patients

Kurzawa¹,

Owczarek²,

Strzelczyk³

et al. 2016

Adv Clin Exp Med

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Quantitative measurement of brain iron deposition in patients with haemodialysis using susceptibility mapping

et al. 2014

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To compare the susceptibility of different brain structures in patients with haemodialysis with that in healthy controls using susceptibility mapping and explore the correlations with neuropsychiatric tests and clinical parameters. Fifty three patients with haemodialysis and forty-five age-and sex-matched healthy controls were recruited in this prospective study. Susceptibility maps (SM) were reconstructed from original phase data and used to compare the susceptibility of different brain structures between patients and healthy controls. The SM was compared with iron predictions from a classic cadaver brain study. Spearman's correlation and stepwise multiple regression analysis between susceptibility and neuropsychiatric tests and clinical parameters were calculated. In patients with haemodialysis, the susceptibility of the bilateral caudate head, putamen, substantia nigra, red nucleus and dentate nucleus were significantly higher than those in healthy controls (P < 0.01). There was positive correlation between susceptibility both from normal controls and patients and iron concentration from a classic post-mortem brain study (both r = 0.900, both P = 0.037). In patients with haemodialysis, the susceptibility of the left putamen (r = 0.944), right putamen (r = 0.882) and right thalamus (r = 0.852) were correlated to dialysis duration (all P < 0.05). The susceptibility of the left caudate head (r = -0.415) and right caudate head (r = -0.311) were mildly negatively correlated with neuropsychiatric test scores (all P < 0.05). In summary, our findings indicated that increased brain iron deposition does occur in patients with haemodialysis and correlated with duration of dialysis.

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Relationship between hepcidin and ferritin in haemodialysed patients

Abstract: It seems that the influence of inflammation on hepcidin levels in haemodialysed patients is not crucial and other factors (e.g. hepcidin retention) are involved.

Cited by 5 publications

References 23 publications

Iron Localization and Infectious Disease in Chronic Kidney Disease Patients

Iron Localization and Infectious Disease in Chronic Kidney Disease Patients

The Content of Reticulocyte Hemoglobin and Serum Concentration of the Soluble Transferrin Receptor for Diagnostics of Anemia in Chronically Hemodialyzed Patients

Quantitative measurement of brain iron deposition in patients with haemodialysis using susceptibility mapping

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