Relationship Between High Circulating Adiponectin With Bone Mineral Density and Bone Metabolism in Elderly Males With Chronic Heart Failure

Metabolism and the heart: An overview of muscle, fat, and bone metabolism in heart failure

“…In leptindeficient mice, a high bone mass was observed, which was mediated through a central effect by altering the activity of the sympathetic nervous system, but also a direct effect of leptin on osteoblasts and bone marrow stromal cells has been described [128]. In agreement with the previous study [121], we have recently showed an inverse and independent relationship between leptin concentrations and bone mineral content in HF patients after controlling for total fat mass and renal function [83]. Interestingly, in the multivariate statistical model of the cited study, the influence of fat mass on bone was stronger than that of adiponectin and leptin on bone in HF patients, suggesting that adipose tissue can influence bone through other mechanisms than by adipokines.…”

“…Previous studies have shown that in chronic HF, bone and muscle losses are linked [83,84]. Thus, the association could be explained by decreased mechanical loading of the muscle on the skeleton because of lower physical performance or related bone and muscle loss may reflect parallel consequences of catabolic over anabolic domination in HF.…”

“…Serum adiponectin levels are higher in HF patients compared to healthy controls and are related to deteriorated prognosis [126,127]. Our recent study provided for the first time evidence that increased serum adiponectin was independently associated with reduced BMD in elderly patients with non-cachectic HF [83]. Additionally, a significant positive correlation of serum adiponectin and RANKL levels was demonstrated in patients with HF.…”

“…liver cirrhosis or chronic bronchitis), having adverse influence on quality of life [82]. Bone status in stable chronic HF patients has been rarely studied so far [83,84,85]. In total, available data suggest that stable pre-transplant chronic HF patients have a significant but only moderately disturbed bone metabolism compared with cachectic HF patients or those who are candidates for heart transplantation [86].…”

“…Bone markers can be used to characterize actual bone metabolism and can be helpful to explain possible mechanisms of bone loss. In our recently published study, increased serum levels of osteocalcin and β-CrossLaps were present in HF patients indicating high bone turnover [83]. Another study showed strong elevation of bone resorption markers in HF patients that correlated negatively with left ventricular ejection fraction [91].…”