Relationship between insulin resistance, metabolic syndrome components and serum uric acid

Adnan, Endy; Rahman, Ilham Akbar; Faridin, H.P.

doi:10.1016/j.dsx.2019.04.001

Cited by 52 publications

(41 citation statements)

References 22 publications

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“…A recent systematic review found that metabolic syndrome is common among patients with COPD that is found in about one-third of them [30]. Since there is a strong association between insulin resistance, metabolic syndrome and hyperuricemia, [31] the observed higher level of serum uric acid level could be confounded by co-morbidities rather than COPD itself.…”

Section: Discussionmentioning

confidence: 99%

Chronic Obstructive Pulmonary Disease is Associated with a Higher Level of Serum Uric Acid. A Systematic Review and Meta-Analysis

Wattanachayakul

Rujirachun

Charoenngam

et al. 2020

Advances in Respiratory Medicine

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Introduction: Recent studies have suggested that patients with chronic obstructive pulmonary disease (COPD) may have a higher level of serum uric acid compared with individuals without COPD, although the data are still limited. The current systematic review and meta-analysis was conducted to summarize all available data. Material and methods: A systematic review was performed using the MEDLINE and EMBASE databases from their inception to July 2019. Studies that were eligible for the meta-analysis must have consisted of two groups of participants, patients with COPD and individuals without COPD. The eligible studies must have reported either mean or median level of serum uric acid and its standard deviation (SD) or interquartile range of participants in both groups. Mean serum uric acid level and SD of participants in both groups were extracted from each study and the mean difference (MD) was calculated. Pooled MD was then computed by combining MDs of each study using random effects model. Results: A total of eight studies with 1,612 participants met the eligibility criteria and were included in the data analysis. The serum uric acid level among patients with COPD was significantly higher than individuals without COPD with the pooled MD of 0.91 mg/dL (95% CI: 0.45-1.38; I 2 = 89%). Conclusions: The current study found a significantly higher level of serum uric acid among patients with COPD than individuals without COPD.

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Section: Discussionmentioning

confidence: 99%

Chronic Obstructive Pulmonary Disease is Associated with a Higher Level of Serum Uric Acid. A Systematic Review and Meta-Analysis

Wattanachayakul

Rujirachun

Charoenngam

et al. 2020

Advances in Respiratory Medicine

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“…Its presence is involved in the development of various diseases such as fatty liver, diabetes mellitus (DM), cancer, and cardiovascular and infectious diseases [3,4]. Prior research indicates that insulin resistance (IR) plays an important role in the pathophysiology of this condition [5]. Considering this, TyG and TG/HDL ratio are simple and practical surrogate markers for insulin resistance that can be used in primary healthcare [6].…”

Section: Introductionmentioning

confidence: 99%

Serum Uric Acid Is Associated with Metabolic Syndrome and Insulin Resistance among Health Personnel from Peru

Galindo-Yllu

Rojas-Humpire

Toro-Huamanchumo

et al. 2021

Journal of Nutrition and Metabolism

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We explored the association between serum uric acid (SUA) and metabolic syndrome (MetS) and insulin resistance (IR) among health personnel from a public hospital in Peru in a cross-sectional study with data from the Plan for the Prevention and Surveillance of Communicable and Noncommunicable Diseases of Huaycán Hospital. MetS was defined according to Latin American Diabetes Association (ALAD) criteria and IR with surrogate IR markers, triglyceride-to-HDL-C ratio (TG/HDL-C), and triglyceride-to-glucose index (TyG). The association between SUA and MetS and IR was determined using Poisson regression models in a sample of 292 participants with an average age of 46.2 ± 10.6 years. The total prevalence of MetS was 38%, and the individuals with MetS presented mainly alterations in anthropometric parameters (obesity and body fat). Finally, the adjusted regression models showed that women with SUA in the highest tertile increased the prevalence of MetS (PR: 1.71, 95% CI: 1.07–2.74) compared to the lowest tertile of SUA in women, while SUA increased hypertriglyceridemia and IR (TG/HDL-C and TyG) in both sexes. We concluded that SUA is strongly associated with MetS in women, and SUA increases hypertriglyceridemia and IR in both sexes. On the contrary, more research is required regarding the female population.

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“…Current evidence suggests that insulin resistance plays a critical role in the pathogenesis of metabolic syndrome (Adnan et al, 2019). Therefore, enhancing insulin sensitivity is widely considered as an effective treatment strategy for metabolic syndrome.…”

Section: Discussionmentioning

confidence: 99%

Kun-Dan Decoction Ameliorates Insulin Resistance by Activating AMPK/mTOR-Mediated Autophagy in High-Fat Diet-Fed Rats

Zeng

Feng

et al. 2021

Front. Pharmacol.

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Background: Metabolic syndrome is characterized by central obesity, hyperglycemia and hyperlipidemia. Insulin resistance is the leading risk factor for metabolic syndrome. Kun-Dan decoction (KD), a traditional Chinese medicine, has been applied to treat patients with metabolic syndrome for over ten years. It is increasingly recognized that autophagy deficiency is the key cause of metabolic syndrome. Therefore, we aimed to explore whether KD can activate autophagy to improve metabolic syndrome.Methods: Network pharmacology was used to explore the underlying mechanism of KD in the treatment of metabolic syndrome. The high-fat diet-fed rats and oleic acid-induced LO2 cells were employed in our study. Oral glucose tolerance test and insulin tolerance test, obesity and histological examination, serum cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), homeostasis model assessment of insulin resistance (HOMA-IR) and insulin sensitivity in high-fat diet-fed rats were analyzed. Furthermore, the protein expressions of adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK), phospho-AMPK, mammalian target of rapamycin (mTOR), phospho-mTOR, p62, autophagy related protein (Atg) 5, Atg7, Atg12, Atg13, Atg16L1 and microtubule-associated protein 1A/1B-light chain 3 (LC3)-Ⅱ/Ⅰ were examined in rats and LO2 cells. Moreover, autophagy activator rapamycin and inhibitor 3-methyladenine, and small interfering RNA against Atg7 were utilized to verify the role of autophagy in the treatment of metabolic syndrome by KD in oleic acid-induced LO2 cells.Results: Results from network pharmacology indicated that targeted insulin resistance might be the critical mechanism of KD in the treatment of metabolic syndrome. We found that KD significantly suppressed obesity, serum cholesterol, triglyceride and LDL-C levels and increased serum HDL-C level in high-fat diet-fed rats. Furthermore, KD enhanced insulin sensitivity and attenuated HOMA-IR in high-fat diet-fed rats. Western blot showed that KD could enhance autophagy to increase the insulin sensitivity of high-fat diet-fed rats and oleic acid-induced LO2 cells. Furthermore, 3-methyladenine and small interfering RNA against Atg7 could reverse the protective effect of KD on LO2 cells. However, rapamycin could cooperate with KD to enhance autophagic activation to increase insulin sensitivity in LO2 cells.Conclusion: The induction of autophagy may be the major mechanism for KD to improve insulin resistance and metabolic syndrome.

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Relationship between insulin resistance, metabolic syndrome components and serum uric acid

Cited by 52 publications

References 22 publications

Chronic Obstructive Pulmonary Disease is Associated with a Higher Level of Serum Uric Acid. A Systematic Review and Meta-Analysis

Chronic Obstructive Pulmonary Disease is Associated with a Higher Level of Serum Uric Acid. A Systematic Review and Meta-Analysis

Serum Uric Acid Is Associated with Metabolic Syndrome and Insulin Resistance among Health Personnel from Peru

Kun-Dan Decoction Ameliorates Insulin Resistance by Activating AMPK/mTOR-Mediated Autophagy in High-Fat Diet-Fed Rats

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