Relationship Between Mammographic Density and Breast Cancer Death in the Breast Cancer Surveillance Consortium

Gierach, Gretchen L.; Ichikawa, Laura; Kerlikowske, Karla; Brinton, Louise A.; Farhat, Ghada N.; Vacek, Pamela M.; Weaver, Donald L.; Schairer, Catherine; Taplin, Stephen H.; Sherman, Mark E.

doi:10.1093/jnci/djs327

Cited by 135 publications

(105 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Risk factors for LRR are not the same as those for death because there are reasonable salvage treatments, which may partly explain why high breast density is not significantly correlated with death. Gierach et al [20] reported that breast imaging-reporting and data system (BIRADS) density categories are not related to the risk of death, which is consistent with our study finding. Interestingly, they pointed out that patients with breast cancer with a low breast density, and who are obese (BMI >30 kg/m 2 ) have increased risk of death; this is probably due to increased BMI, larger adipocyte size, and breast microenvironments that provide a stimulus for tumor growth, which was not seen in our study.…”

Section: Discussionsupporting

confidence: 93%

High mammographic breast density predicts locoregional recurrence after modified radical mastectomy for invasive breast cancer: a case-control study

et al. 2016

View full text Add to dashboard Cite

BackgroundWe aimed to evaluate the influence of mammographic breast density at diagnosis on the risk of cancer recurrence and survival outcomes in patients with invasive breast cancer after modified radical mastectomy.MethodsThis case-control study included 121 case-control pairs of women diagnosed with invasive breast cancer between 2004 and 2009, and who had undergone modified radical mastectomy and had mammographic breast density measured before or at diagnosis. Women with known locoregional recurrence or distant metastasis were matched by pathological disease stage, age, and year of diagnosis to women without recurrence. Locoregional recurrence was defined as recurrence in the ipsilateral chest wall, or axillary, internal mammary, or supraclavicular nodes. The median follow-up duration was 84.0 months for case patients and 92.9 months for control patients.ResultsPatients with heterogeneously dense (50–75% density) and extremely dense (>75% density) breasts had an increased risk of locoregional recurrence (hazard ratios 3.1 and 5.7, 95% confidence intervals 1.1–9.8 and 1.2–34.9, p = 0.043 and 0.048, respectively) than did women with less dense breasts. Positive margins after surgery also increased the risk of locoregional recurrence (hazard ratio 3.3, 95% confidence interval 1.3–8.3, p = 0.010). Multivariate analysis that included dense breasts (>50% density), positive margin, no adjuvant radiotherapy, and no adjuvant chemotherapy revealed that dense breasts were significant factors for predicting locoregional recurrence risk (hazard ratio 3.6, 95% confidence interval 1.2–11.1, p = 0.025).ConclusionsOur results demonstrate that dense breast tissue (>50% density) increased the risk of locoregional recurrence after modified radical mastectomy in patients with invasive breast cancer. Additional prospective studies are necessary to validate these findings.Trial registrationThe study is retrospectively registered with ClinicalTrials.gov, number NCT02771665, on May 11, 2016.

show abstract

Section: Discussionsupporting

confidence: 93%

High mammographic breast density predicts locoregional recurrence after modified radical mastectomy for invasive breast cancer: a case-control study

et al. 2016

View full text Add to dashboard Cite

show abstract

“…However, the observed effect of young age on prognosis persisted in multivariate analysis taking such variables into account. Moreover, differences in breast density seem not to affect the final outcome [15]. Thus, biological differences may underly the distinct prognosis in very young patients compared to older women.…”

Section: Discussionmentioning

confidence: 97%

The prognostic impact of age in different molecular subtypes of breast cancer

Liedtke

Rody

Gluz

et al. 2015

Breast Cancer Res Treat

View full text Add to dashboard Cite

Breast cancer is a heterogeneous entity composed of distinct molecular subgroups with different molecular and clinical features. We analyzed the association between molecular breast cancer subgroups, age at diagnosis, and prognosis in a compilation of publicly available gene expression datasets. Affymetrix gene expression data (U133A or U133Plus2.0 arrays) of 4467 breast cancers from 40 datasets were compiled and homogenized. Breast cancer subgroups were defined based on expression of ESR1, PR, HER2, and Ki67. Event-free survival was calculated as recurrence-free survival or distant metastasis-free survival if recurrence-free survival was not available. Young age at diagnosis is associated with higher frequency of triple negative and HER2 subtypes and lower frequency of luminal A breast cancers. The 5-year event-free survival rates of patients aged less than 40, between 40 and 50, and >50 years were 54.3 ± 3.5, 68.5 ± 1.9, and 70.4 ± 1.3 %, respectively. When controlling for breast cancer subtype, we found that age <40 years remained significantly associated with poor prognosis in triple negative breast cancer. The effect was modest in luminal tumors and not found in HER2 subtype. Both subtypes and age retained their significances in multivariate analysis. Association of age at diagnosis with molecular breast cancer subtype contributes to its important role as prognostic factor among patients with breast cancer. Still, within the group of triple negative breast cancer, young age <40 years has a significant prognostic value which was retained in multivariate analysis.

show abstract

“…In a Swedish trial, patients with high BD at screening mammograms had worse survival that was of borderline significance [19] which was not found in British and US cohorts [20,21]. BD is a modifiable trait affected by several genetic, hormonal, biological, and environmental factors that can change over time [22].…”

Section: Discussionmentioning

confidence: 99%

Mammographic breast density: Predictive value for pathological response to neoadjuvant chemotherapy in breast cancer patients

et al. 2015

View full text Add to dashboard Cite

show abstract

Relationship Between Mammographic Density and Breast Cancer Death in the Breast Cancer Surveillance Consortium

Cited by 135 publications

References 30 publications

High mammographic breast density predicts locoregional recurrence after modified radical mastectomy for invasive breast cancer: a case-control study

High mammographic breast density predicts locoregional recurrence after modified radical mastectomy for invasive breast cancer: a case-control study

The prognostic impact of age in different molecular subtypes of breast cancer

Mammographic breast density: Predictive value for pathological response to neoadjuvant chemotherapy in breast cancer patients

Contact Info

Product

Resources

About