Relationship between maternal thyroid-stimulating hormone (TSH) elevation during pregnancy and low birth weight: A longitudinal study of apparently healthy urban Japanese women at very low risk

Nishioka, Emiko; Hirayama, Satoshi; Ueno, Toshihide; Matsukawa, Tetsuya; Vigeh, Mohsen; Yokoyama, Kazuhito; Makino, Shintaro; Takeda, Satoru; Miida, Takashi

doi:10.1016/j.earlhumdev.2014.12.014

Cited by 18 publications

(11 citation statements)

References 30 publications

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“…Many previous studies found an increased risk of small infants (i.e. SGA, LBW) in relation to hypothyroid mothers, but this was not reported consistently . A major limitation of these studies is that they did not include LGA or macrosomia as major outcomes, possibly because the risk of LGA was not recognized as fully as that of SGA.…”

Section: Discussionmentioning

confidence: 92%

Preconception TSH and pregnancy outcomes: a population‐based cohort study in 184 611 women

Chen

Zhou

Zhu

et al. 2017

Clinical Endocrinology

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Section: Discussionmentioning

confidence: 92%

Preconception TSH and pregnancy outcomes: a population‐based cohort study in 184 611 women

Chen

Zhou

Zhu

et al. 2017

Clinical Endocrinology

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“…The results showed that a decrease in TSH levels is an independent determinant of neonatal birth weight. 24 …”

Section: Discussionmentioning

confidence: 99%

Prevalence of subclinical hypothyroidism in pregnancy in Saudi Arabia

Shanqeeti

Alkhudairy

Alabdulwahed

et al. 2018

SMJ

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objectives:To estimate the prevalence of subclinical hypothyroidism (SCH) in Saudi Arabia and assess the need for an SCH screening program.Methods:This cross-sectional study was conducted at King Abdulaziz Medical City and the Khashmulaan Clinic at the National Guard Health Affairs, Riyadh, Saudi Arabia in August 2016. All women attending the antenatal clinics were invited to participate in the study. In addition, data were retrieved from the files of pregnant women who had been screened for hypothyroidism from January 2016 to August 2016. A total of 384 pregnant women were included in the study.Results:The prevalence of SCH in pregnant women in this study was 50/384 (13%) with 95% confidence intervals (CIs): 9.82%-16.80%. Pregnant women who were randomly screened using a survey (n=127) were 3 times more likely (OR: 3.1; 95% CI: 1.182 to 8.704, p=0.022) to have SCH compared to pregnant women who were screened based on their physician’s judgement (n=257). Results showed older age (≥40 years) was associated with an insignificant decrease in the risk of SCH.Conclusion:Random screening for SCH in pregnant women showed a higher prevalence in comparison to women who were screened as a result of physician referrals. The results highlight the urgent need for larger studies to investigate the prevalence of SCH as well as the need for an SCH screening program.

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“…There are reports showing a significant relationship of elevated TSH, regardless of OH or SH, with adverse pregnancy outcomes, including miscarriage [14,21], preterm birth [22], and low birthweights [15]. This might support the adequacy in the screening of hypothyroidism only with serum TSH level, even without the diagnosis of OH or SH.…”

Section: Discussionmentioning

confidence: 83%

“…A higher prevalence of SH in infertile women has been reported [5,11], and some researchers recommend levothyroxine supplementation for women with SH undergoing assisted reproductive technology (ART) to improve clinical pregnancy rate [12,13]. Moreover, some researchers have reported that only elevated TSH, not free thyroxine level, was associated with adverse pregnancy outcomes, indicating that serum TSH level is a potential index for female reproduction issue [14,15]. Nevertheless, in the absence of satisfactory objective data, the influence of SH or elevated TSH on female infertility and the definition on the normal range of TSH in infertile women remains to be a matter of controversy.…”

Section: Introductionmentioning

confidence: 99%