Relationship Between Metabolic Syndrome and Carotid Intima‐Media Thickness: Cross‐Sectional Comparison Between Psoriasis and Psoriatic Arthritis

Lin, Yih Chang; Dalal, Deepan; Churton, Sarah; Brennan, Danielle M.; Korman, Neil J.; Kim, Esther S.H.; Husni, M. Elaine

doi:10.1002/acr.22144

Cited by 50 publications

(38 citation statements)

References 24 publications

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“…Another study conducted in a large cohort of psoriatic patients have underlined that the risk of CV mortality was 50% higher compared to the general population [42] . These data were confirmed by Lin et al [43] , who detected that patients affected by psoriatic arthritis (PsA) had an increased prevalence of metabolic syndrome with significantly greater carotid intimamedia thickness compared to patients with psoriasis only. Furthermore, greatest CIMT measurements were detectable in PsA patients with metabolic syndrome compared to PsA patients without metabolic syndrome and psoriasis patients with or without metabolic syndrome [43] .…”

Section: Psoriasis and Prothrombotic Statesupporting

confidence: 76%

Non-alcoholic fatty liver disease and psoriasis: So far, so near

Ganzetti

Campanati

Offidani

2015

WJH

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Psoriasis is a chronic inflammatory immune-mediated skin diseases which is frequently associated to comorbidities. Non-alcoholic fatty liver disease (NAFLD) is defined as an excessive accumulation of triglycerides in hepatocytes and includes a wide spectrum of liver conditions ranging from relatively benign steatosis to non-alcoholic steatohepatitis with fatty infiltration and lobular inflammation and to cirrhosis and endstage liver disease. Actually, psoriasis is considered a systemic diseases associated to comorbidities, as metabolic syndrome and NAFLD is seen the hepatic manifestation of the metabolic syndrome. The possible link between psoriasis, obesity and metabolic syndrome, which are known risk factors for NAFLD has been recently documented focusing in the crucial role of the adipose tissue in the development of the inflammatory background sharing by the above entities. According to recent data, patients with psoriasis show a greater prevalence of NAFLD and metabolic syndrome than the general population. Moreover, patients with NAFLD and psoriasis are at higher risk of severe liver fibrosis than those with NAFLD and without psoriasis. The link between these pathological conditions appears to be a chronic low-grade inflammatory status. The aim of this review is to focus on the multiple aspects linking NAFLD and psoriasis, only apparently far diseases. Core tip: The review focuses on the multiple physiopathogenetic aspects of the possible link between psoriasis and non-alcoholic fatty liver disease (NAFLD) emphasizing the most recent scientific data. The importance of the multidisciplinary approach to patients affected by psoriasis is underlined and the therapeutic options to treat concomitant psoriasis and NAFLD is discussed evaluating the risk benefit of both biologic and non-biologic therapies.Ganzetti G, Campanati A, Offidani A. Non-alcoholic fatty liver disease and psoriasis: So far, so near. World J Hepatol 2015; 7(3): 315-326 Available from:

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Section: Psoriasis and Prothrombotic Statesupporting

confidence: 76%

Non-alcoholic fatty liver disease and psoriasis: So far, so near

Ganzetti

Campanati

Offidani

2015

WJH

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“…Among individuals with PsA, a significant correlation between serum uric acid levels and subclinical atherosclerosis was found as indicated by increased carotid intima-medial thickness 37 38 45. Onat et al 46 showed that elevated uric acid levels correlate with a pro-inflammatory state and high-density lipoprotein dysfunction and that risk of coronary heart disease is independently predicted by elevated uric acid levels in non-diabetic men, modulated by the metabolic syndrome and gender.…”

Section: Discussionmentioning

confidence: 99%

Psoriasis, psoriatic arthritis and risk of gout in US men and women

Merola

Han

et al. 2014

Ann Rheum Dis

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Objective Individuals with psoriasis have been found to have increased blood levels of uric acid. However, there is no prospective data on the association between psoriasis and uric acid levels and subsequent development of gout. In this study, we examined the risk of gout among individuals with psoriasis and psoriatic arthritis (PsA) in two cohorts of men and women, the Health Professionals Follow-up Study (HPFS) (1986-2010) and Nurses' Health Study (NHS) (1998-2010). Methods A total of 27,751 men and 71,059 women were included in the analysis. Lifetime history of physician-diagnosed incident psoriasis and PsA was confirmed by validated supplementary questionnaires. Incident gout diagnoses were confirmed based on the American College of Rheumatology survey criteria. We used Cox proportional hazards models controlling for potential risk factors to calculate the hazard ratios (HRs) with 95% confidence intervals (CIs) of incident gout while simultaneously adjusting for several common risk factors. Results We documented 2,217 incident cases of gout during the follow-up. Psoriasis was associated with an increased risk of subsequent gout with a multivariate HR of 1.71 [95% confidence interval (CI), 1.36-2.15] in the pooled analysis. Risk of gout was substantially augmented among those with psoriasis and concomitant PsA [pooled multivariate HR: 4.95, (95% CI, 2.72 to 9.01)] when compared to participants without psoriasis. Conclusions In this prospective study of US women and men, psoriasis and PsA were associated with an increased risk of gout.

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“…In this study, among patients without PsA, the prevalence of MetS was comparable to an estimated prevalence of MetS in the Western population of 15-24% 7,8 . There are now emerging data investigating the association of burden of inflammation in PsA with comorbidities 9,10 . For example, a recent study has shown that the cumulative inflammatory burden, as reflected by cumulative averages of repeated measures of erythrocyte sedimentation rate, was associated with increased arterial stiffness in patients with PsA, even after adjustment for CV risk factors, emphasizing the important involvement of chronic inflammation in accelerating the development of CVD in patients with PsA 9 .…”

Section: To the Editormentioning

confidence: 99%