Relationship between metabolic syndrome and follicle-stimulating hormone in postmenopausal women

Lee, Suk Woo; Hwang, In-Sul; Jung, Gyul; Kang, Hee; Chung, Yoo Hyun

doi:10.1097/md.0000000000029216

Cited by 11 publications

(8 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides these reproductive roles, FSH may also affect glucose metabolism. A recent systematic review suggests an inverse relationship between FSH levels and insulin resistance and a beneficial effect of FSH on glucose metabolism in postmenopausal women [31]. One of the studies discussed by this systematic review examined the relationship between FSH level, type 2 diabetes, and insulin resistance in postmenopausal women and found that higher FSH levels were associated with lower prevalence and incidence of type 2 diabetes and lower fasting insulin levels in this population [32].…”

Section: Follicle Stimulating Hormonementioning

confidence: 89%

Type 1 Diabetes and the Menstrual Cycle: Where/How Does Exercise Fit in?

Toor

Yardley

Momeni

2023

IJERPH

View full text Add to dashboard Cite

Regular exercise is associated with substantial health benefits for individuals with type 1 diabetes (T1D). However, the fear of hypoglycemia (low blood glucose) due to activity-induced declines in blood glucose levels acts as a major barrier to partaking in exercise in this population. For females with T1D, hormonal fluctuations during the menstrual cycle and their effects on blood glucose levels can act as an additional barrier. The impact that these cyclic changes may have on blood glucose and insulin needs and the consequent risk of hypoglycemia during or after exercise are still unknown in this population. Therefore, in this narrative review, we gathered existing knowledge about the menstrual cycle in T1D and the effects of different cyclic phases on substrate metabolism and glucose response to exercise in females with T1D to increase knowledge and understanding around exercise in this underrepresented population. This increased knowledge in such an understudied area can help to better inform exercise guidelines for females with T1D. It can also play an important role in eliminating a significant barrier to exercise in this population, which has the potential to increase activity, improve mental health and quality of life, and decrease the risk of diabetes-related complications.

show abstract

Section: Follicle Stimulating Hormonementioning

confidence: 89%

Type 1 Diabetes and the Menstrual Cycle: Where/How Does Exercise Fit in?

Toor

Yardley

Momeni

2023

IJERPH

View full text Add to dashboard Cite

show abstract

“…Chabrolle et al have demonstrated that ovarian adiponectin, adipoR1, and adipoR2 mRNA levels can be regulated by human chorionic gonadotropin (37). Additionally, a correlation between elevated FSH levels and improved insulin sensitivity has been reported, characterized by elevated adiponectin levels in the bloodstream (38). FSH has also been shown to promote ovulation by increasing the production of adiponectin in ovarian follicular fluid (39).…”

Section: Discussionmentioning

confidence: 99%

A novel role of FSH on regulating ovarian adiponectin expression in rat ovarian granulosa cells

Zhou,

Zhang,

Jia

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: Adiponectin, also known as Acrp30, GBP28, or apM1, plays a crucial role in regulating glucose levels, lipid metabolism and insulin sensitivity in various tissues and organs. Despite its broad physiological relevance in female reproduction, its role in ovarian adiponectin secretion and energy utilization remains unknown. Methods: In the present investigation, we employed a suite of sophisticated molecular and cellular techniques to elucidate the expression of lipocalin system components and glucose transporter proteins within the ovarian tissue of rats. Specifically, cellular immunofluorescence, RT-PCR, Western blotting, and immunohistochemistry, alongside ELISA, were meticulously applied for the identification of these proteins. Furthermore, granulosa cells, harvested from rat ovaries, were subjected to an in vitro culture protocol to establish a primary cell culture. Results: In our study, we utilized primary cultured rat granulosa cells to demonstrate for the first time that FSH quickly stimulated adiponectin protein expression in granulosa cells, particularly through the PKA signaling pathway. Consistently, further in vivo study indicated that eCG administration significantly increased adiponectin protein levels in rat ovaries. The subsequent ovarian transcriptome and RT-PCR analysis showed a positive correlation between the expression of intraovarian glucose transporters (Slc2a1, Slc2a3, and Slc2a4) and the adiponectin system (Adipoq, Adipor1, and Adipor2), as well as the protein expression patterns. Although eCG administration in rats notably elevated circulating adiponectin levels, it had no significant effects on blood glucose levels. The current findings proved that AdipoRon (an AdipoR agonist) significantly increased the expression of glucose transporters (GLUT1 and GLUT2) proteins levels, enhancing glucose uptake in granulosa cells. Conclusions: These findings indicate that FSH may modulate ovarian glucose transporter protein expression and glucose utilization through the autocrine actions of adiponectin, thereby influencing ovarian development and function.

show abstract

“…This is caused by a change in hormonal secretion due to a decrease in ovarian function. From the menopausal transition to menopause, diminished ovarian function leads to hormonal changes characterized by decreases in reproductive hormones, including estrogen, progesterone, testosterone, and inhibin B ( 47 ). Depletion of ovarian reserve during the menopausal transition raises follicle-stimulating hormone (FSH) markedly.…”

Section: Discussionmentioning

confidence: 99%

The prevalence and clustering of metabolic syndrome risk components in Chinese population: a cross-sectional study

Zhao,

Lu,

Song

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

ObjectiveThe metabolic syndrome (MetS) is diagnosed upon the manifestation of ≥ 3 out of 5 specific components. The present study evaluated the epidemiological characteristics of the MetS components and their clustering condition among Chinese adults.Methods68383 participants aged 18-80 years from TIDE were scored on a six-point (0–5) MetS severity score (MSSS), which quantified their cumulative amount of MetS risk components. We evaluated the epidemiological characteristics of these components and their clustering conditions. Additionally, we examined the relation of age with the prevalence of different MSSSs or specific MetS components using restricted cubic splines.ResultsAmong 68383 participants, 26113 men and 24582 women had abnormal MetS components. There were significant differences in most epidemiological characteristics between the 6 MSSS groups. The top three prevalence of abnormal metabolic components were high systolic blood pressure (SBP) (9.41%, n=6568), high waist circumference (WC) (8.13%, n=6120), and the cooccurrence of high SBP and high WC (6.33%, n=4622). Participants were more likely to have all five MetS components when HDL-C was low. Restricted cubic splines showed that when the MSSS ≥3, the MetS prevalence of male peaked and that of the female population increased most rapidly at 40-60 age group.ConclusionThe 40-60 age group can be regarded as the high-risk period of MetS, and elderly women have a higher risk of multiple metabolic disorders than men. The top three clustering of abnormal metabolic components were high SBP, high WC, and their combination. Multiple components aggregation was more likely to occur when HDL-C decreased.

show abstract

Relationship between metabolic syndrome and follicle-stimulating hormone in postmenopausal women

Cited by 11 publications

References 39 publications

Type 1 Diabetes and the Menstrual Cycle: Where/How Does Exercise Fit in?

Type 1 Diabetes and the Menstrual Cycle: Where/How Does Exercise Fit in?

A novel role of FSH on regulating ovarian adiponectin expression in rat ovarian granulosa cells

The prevalence and clustering of metabolic syndrome risk components in Chinese population: a cross-sectional study

Contact Info

Product

Resources

About