Relationship between metabolites of arachidonic acid and prognosis in patients with acute coronary syndrome

Zu, Lingyun; Guo, Guijie; Zhou, Jie; Gao, Wei

doi:10.1016/j.thromres.2016.06.031

Cited by 44 publications

(30 citation statements)

References 23 publications

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“…Recent studies provide strong evidence that P450 enzymes and their AA metabolites play differential roles in most cardiac diseases; some of these metabolites are cadiotoxic, others showed cardioprotective effects (Westphal et al, 2015;Zu et al, 2016). One group of AA metabolites that have not been fully studied with respect to cardiac hypertrophy is subterminal HETEs, specifically 16-, 17-, 18-, and 19-HETE.…”

Section: Discussionmentioning

confidence: 99%

“…19-HETE acts as an endogenous antagonist of 20-HETE and inhibits its mediated vasoconstrictor effects (Elshenawy et al, 2017). Additionally, acute coronary syndrome patients with higher plasma levels of 19-HETE have significantly better prognosis than those who have lower plasma levels (Zu et al, 2016). In a pressure overload-induced cardiac hypertrophy model, there was a significant decrease of the level of 19-HETE in hypertrophied hearts compared with control group (El-Sherbeni and El-Kadi, 2014).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

S-Enantiomer of 19-Hydroxyeicosatetraenoic Acid Preferentially Protects Against Angiotensin II-Induced Cardiac Hypertrophy

Shoieb

El‐Kadi

2018

Drug Metabolism and Disposition

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We had recently demonstrated that the racemic mixture of 19-hydroxyeicosatetraenoic acid (19-HETE) protects against angiotensin II (Ang II)-induced cardiac hypertrophy. Therefore, the purpose of this study was to investigate whether the orenantiomer of 19-HETE confers cardioprotection against Ang II-induced cellular hypertrophy in RL-14 and H9c2 cells. Both cell lines were treated with vehicle or 10 M Ang II in the absence and presence of 20M 19()HETE or 19()HETE for 24 hours. Thereafter, the level of midchain HETEs was determined using liquid chromatography-mass spectrometry. Gene- and protein-expression levels were measured using real-time polymerase chain reaction and Western blot analysis, respectively. The results showed that both 19()HETE and 19()HETE significantly decreased the metabolite formation rate of midchain HETEs, namely 8-, 9-, 12-, and 15-HETE, compared with control group, whereas the level of 5-HETE was selectively decreased by enantiomer. Moreover, both 19()HETE and 19()HETE significantly inhibited the catalytic activity of CYP1B1 and decreased the protein expression of 5- and 12-lipoxygenase (LOX) as well as cyclo-oxygenase-2 (COX-2). Notably, the decrease in 15-LOX protein expression was only mediated by 19()HETE. Interestingly, both enantiomers protected against Ang II-induced cellular hypertrophy, as evidenced by a significant decrease in mRNA expression of /-myosin heavy chain ratio, atrial natriuretic peptide, and interleukins 6 and 8. Our data demonstrated that enantiomer of 19-HETE preferentially protected against Ang II-induced cellular hypertrophy by decreasing the level of midchain HETEs, inhibiting catalytic activity of CYP1B1, decreasing protein expression of LOX and COX-2 enzymes, and decreasing mRNA expression of IL-6 and IL-8.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

S-Enantiomer of 19-Hydroxyeicosatetraenoic Acid Preferentially Protects Against Angiotensin II-Induced Cardiac Hypertrophy

Shoieb

El‐Kadi

2018

Drug Metabolism and Disposition

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“…Furthermore, 15‐HETE derived from enzymatic ARA oxidation, which is suggested to be a vasoconstrictor and eliminate inflammatory response, was also inhibited in the liver tissues of the HFD + Oat group compared to the HFD group. Instead, our study showed 11‐HETE to be induced in liver tissues of the HFD + Oat group, which in part may be a symptomatic response for atherosclerosis (Zu et al, ). Notwithstanding, 20‐HETE was elevated in the liver and heart tissues of the Oat+HFD group, which further disputes the benefit of oat bran in atherosclerosis.…”

Section: Discussionmentioning

confidence: 66%

Dietary Oat Bran Increases Some Proinflammatory Polyunsaturated Fatty‐Acid Oxidation Products and Reduces Anti‐Inflammatory Products in Apolipoprotein E^−/− Mice

Lee

AlGhawas

Poutanen

et al. 2018

Lipids

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Oat bran is suggested to attenuate atherosclerotic conditions by regulating dyslipidemia, endothelial function, and oxidative damage. Through the measurement of oxidized polyunsaturated fatty acid (PUFA), oxidative stress, and inflammation status in liver and heart tissues of apolipoprotein E −/− (ApoE −/− ), mice fed with high fat diet (HFD) or HFD with oat bran (HFD + Oat) were investigated. Using liquid chromatography tandem mass spectrometry (LC-MS/MS), PUFA and over 40 types of its oxidized products were assessed. The HFD + Oat group had augmented adrenic acid (ADA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) and suppressed n-3 docosapentaenoic acid levels in the liver tissues compared to the HFD group. Arachidonic acid (ARA) and α-linolenic acid (ALA) levels were elevated and ADA was suppressed in the heart tissues of the HFD + Oat group compared to the HFD group. Furthermore, enzymatically mediated oxidized ARA product levels (9-, 11-and 20-HETE [hydroxyeicosatetraenoic acid], and PGF 2α ) were augmented and those of the oxidized DHA products (4-, 7-, 10-, 11-, 13-, and 14-HDHA [hydroxy-docosahexaenoic acid]) were reduced in the liver tissues of the HFD + Oat group. It also increased 17-F 2t -dihomo-isoprostane and 7-F 2t -dihomo-isofuran derived from nonenzymatic oxidation of ADA in the heart and liver tissues, and those from ALA namely 16-F 1t -phytoprostane and 16(RS)-13-epi-STΔ 14 -9-phytofuran. Our study showed oat bran to be a weak antioxidant and lacked anti-inflammatory properties in atherosclerotic mice. Elevation of oxidized PUFA products that are potentially proinflammatory and vasoconstrictors (HETE, PGF 2α ) with simultaneous reduction of those that are anti-inflammatory (HDHA) may not be desirable in the pathogenesis of atherosclerosis.

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“…However, the ambiguous biosynthesis of 9‐HETE and 11‐HETE involves both cytochrome P450 dependent oxygenation and lipid peroxidation . Insofar, the role of 9‐ and 11‐HETE is suggested to involve in generic inflammation, atherosclerosis, ischemia, and myocardial infarction, which are conditions highly related to the risk of disease development in patients with hypercholesterolemia.…”

Section: Discussionmentioning

confidence: 99%

Garlic Supplementation Modified Enzymatic Omega‐6 Polyunsaturated Fatty Acid Oxidation in Mild Hypercholesterolemia

Leung

Yau

Leung

et al. 2019

Euro J Lipid Sci & Tech

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Dietary garlic has been shown to alleviate hypercholesterolemia, a condition associated with the development of cardiovascular disease. Reactive oxygen species take part in the disease progression, but it is unknown if antioxidant rich garlic arrests lipid and cholesterol oxidation in hypercholesterolemia. This study provides fermented garlic or non‐fermented garlic to mild hypercholesterolemia (total cholesterol: 5.2–6.2 mmol L−1) and determines its ability to relieve in vivo oxidative stress by measuring multiple oxidized lipid products of polyunsaturated fatty acid (PUFA) and cholesterol oxidation products (COPs) in plasma. Plasma fatty acids levels are also analyzed. After 13 weeks supplementation, both groups show a significant increase in α‐linolenic acid level (p < 0.05). Levels of arachidic acid increase and palmitoleic acid decreases in the group supplemented with non‐fermented garlic. Of the oxidized PUFA products, notably those derived from enzymatic oxidation of arachidonic acid, namely hydroxyeicosatetraenoic acid (HETE), show a significant difference. Levels of lipoxygenase mediate 5‐HETE and 12‐HETE, and CYP‐P450 mediates 9‐HETE and 11‐HETE decreases after non‐fermented garlic supplementation only (p < 0.05). Non‐enzymatic PUFA oxidation and COPs are not altered by garlic supplementation. Overall, only non‐fermented garlic intake shows selective antioxidant properties in mild hypercholesterolemia where limited effect is found in reducing lipid oxidation. Practical Applications: Current research provides a new insight for the use of garlic extract as a nutraceutical to reduce in vivo oxidative stress. The modified enzymatic oxidation of arachidonic acid in mild hypercholesterolemia after non‐fermented garlic extract intake potentially preventes the progression of chronic inflammation that can lead to complicated pathologies such as arthritis, cardiovascular diseases, and non‐alcoholic fatty liver disease. Garlic is a claimed functional food. The fermented form is proposed to have stronger antioxidant properties. Analysis of mild hypercholesterolemia plasma before and after fermented or non‐fermented garlic extract intake for 13 weeks revealed augmented α‐linolenic acid. Garlic appeared to be selective in the antioxidant property. Pro‐inflammatory lipid mediators (5‐, 9‐, 11‐, and 12‐HETE) released via enzymatic polyunsaturated fatty acid (PUFA) oxidation reduced after non‐fermented garlic extract intake only. However, intake of both garlic types did not reduce non‐enzymatic PUFA oxidation status.

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Relationship between metabolites of arachidonic acid and prognosis in patients with acute coronary syndrome

Cited by 44 publications

References 23 publications

S-Enantiomer of 19-Hydroxyeicosatetraenoic Acid Preferentially Protects Against Angiotensin II-Induced Cardiac Hypertrophy

S-Enantiomer of 19-Hydroxyeicosatetraenoic Acid Preferentially Protects Against Angiotensin II-Induced Cardiac Hypertrophy

Dietary Oat Bran Increases Some Proinflammatory Polyunsaturated Fatty‐Acid Oxidation Products and Reduces Anti‐Inflammatory Products in Apolipoprotein E^−/− Mice

Garlic Supplementation Modified Enzymatic Omega‐6 Polyunsaturated Fatty Acid Oxidation in Mild Hypercholesterolemia

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Relationship between metabolites of arachidonic acid and prognosis in patients with acute coronary syndrome

Cited by 44 publications

References 23 publications

S-Enantiomer of 19-Hydroxyeicosatetraenoic Acid Preferentially Protects Against Angiotensin II-Induced Cardiac Hypertrophy

S-Enantiomer of 19-Hydroxyeicosatetraenoic Acid Preferentially Protects Against Angiotensin II-Induced Cardiac Hypertrophy

Dietary Oat Bran Increases Some Proinflammatory Polyunsaturated Fatty‐Acid Oxidation Products and Reduces Anti‐Inflammatory Products in Apolipoprotein E−/− Mice

Garlic Supplementation Modified Enzymatic Omega‐6 Polyunsaturated Fatty Acid Oxidation in Mild Hypercholesterolemia

Contact Info

Product

Resources

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Dietary Oat Bran Increases Some Proinflammatory Polyunsaturated Fatty‐Acid Oxidation Products and Reduces Anti‐Inflammatory Products in Apolipoprotein E^−/− Mice