Relationship between methanogenic archaea and subgingival microbial complexes in human periodontitis

Horz, Hans-Peter; Robertz, Nora; Vianna, Morgana Eli; Henne, Karsten; Conrads, Georg

doi:10.1016/j.anaerobe.2015.02.008

Cited by 27 publications

(28 citation statements)

References 20 publications

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“…The dominant Archaeon is Methanobrevibacter oralis 16 which has been categorized as a periodontal pathogen due to its strong association to disease 17 and pocket depth 18 . Methanogens have been shown to be co-occurring with Prevotella intermedia , a fermentative species, possibly due to interspecies hydrogen transfer 18 .…”

Section: Introductionmentioning

confidence: 99%

Dysbiosis in chronic periodontitis: Key microbial players and interactions with the human host

Deng

Szafrański

Jarek

et al. 2017

Sci Rep

178

144

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Periodontitis is an extremely prevalent disease worldwide and is driven by complex dysbiotic microbiota. Here we analyzed the transcriptional activity of the periodontal pocket microbiota from all domains of life as well as the human host in health and chronic periodontitis. Bacteria showed strong enrichment of 18 KEGG functional modules in chronic periodontitis, including bacterial chemotaxis, flagellar assembly, type III secretion system, type III CRISPR-Cas system, and two component system proteins. Upregulation of these functions was driven by the red-complex pathogens and candidate pathogens, e.g. Filifactor alocis, Prevotella intermedia, Fretibacterium fastidiosum and Selenomonas sputigena. Nine virulence factors were strongly up-regulated, among them the arginine deiminase arcA from Porphyromonas gingivalis and Mycoplasma arginini. Viruses and archaea accounted for about 0.1% and 0.22% of total putative mRNA reads, respectively, and a protozoan, Entamoeba gingivalis, was highly enriched in periodontitis. Fourteen human transcripts were enriched in periodontitis, including a gene for a ferric iron binding protein, indicating competition with the microbiota for iron, and genes associated with cancer, namely nucleolar phosphoprotein B23, ankyrin-repeat domain 30B-like protein and beta-enolase. The data provide evidence on the level of gene expression in vivo for the potentially severe impact of the dysbiotic microbiota on human health.

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Section: Introductionmentioning

confidence: 99%

Dysbiosis in chronic periodontitis: Key microbial players and interactions with the human host

Deng

Szafrański

Jarek

et al. 2017

Sci Rep

178

144

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“…Archaea differ from Bacteria and Eucarya in terms of genetic (16S ribosomal RNA), biochemical, and structural features . In biofilms obtained from sites with periodontitis there are often elevated levels of Archaea compared with samples taken from healthy sites . The association of Archaea with periodontitis has not been a universal finding .…”

Section: Future Challengesmentioning

confidence: 99%

“…The association of Archaea with periodontitis has not been a universal finding . The Archaea associated with periodontal diseases are all methanogens . The interaction of Archaea with Bacteria in oral biofilms has not been well studied, but it has been reported that the nonspecific adherence of Aggregatibacter actinomycetemcomitans requires genes that are widespread in the Archaea and Bacteria domains …”

Section: Future Challengesmentioning

confidence: 99%

“…187 The Archaea associated with periodontal diseases are all methanogens. 178,179,184,[186][187][188] The interaction of Archaea with Bacteria in oral biofilms has not been well studied, but it has been reported that the nonspecific adherence of Aggregatibacter actinomycetemcomitans requires genes that are widespread in the Archaea and Bacteria domains. 189 Bacteria are, of course, the most studied component of oral biofilms because of their documented relationship to the development of periodontal diseases.…”

Section: Ecological Complexities Of Host-microbial Interactions In mentioning

confidence: 99%

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A brief history of periodontics in the United States of America: Pioneers and thought‐leaders of the past, and current challenges

Armitage

2019

Periodontology 2000

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This paper summarizes historical events in periodontology in the United States over the past 200 years. The contributions of some of the key thought‐leaders of the past are highlighted. Throughout the 20th century, the evolution of thought, leading to the views currently held regarding the pathogenesis and treatment of periodontal diseases, was significantly influenced by: (1) major changes in health‐care education; (2) the emergence of periodontics as a specialty of dentistry; (3) the publication of peer‐reviewed journals with an emphasis on periodontology; (4) formation of the National Institute of Dental and Craniofacial Research (NIDCR); and (5) expansion of periodontal research programs by the NIDCR. The two major future challenges facing periodontal research are development of a better understanding of the ecological complexities of host‐microbial interactions in periodontal health and disease, and identification of the relevant mechanisms involved in the predictable regeneration of damaged periodontal tissues.

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“…In the last decades, a high number of studies have reported the occurrence of Archaea in the subgingival biofilm of subjects with periodontal disease or with a healthy periodontium . They have also been isolated from subgingival samples of patients with periodontitis, peri‐implantitis and infected root canals .…”

Section: Introductionmentioning

confidence: 99%

Effects of different periodontal treatments in changing the prevalence and levels of Archaea present in the subgingival biofilm of subjects with periodontitis: A secondary analysis from a randomized controlled clinical trial

Ramiro

Lira

Soares

et al. 2018

Int J Dental Hygiene

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Relationship between methanogenic archaea and subgingival microbial complexes in human periodontitis

Cited by 27 publications

References 20 publications

Dysbiosis in chronic periodontitis: Key microbial players and interactions with the human host

Dysbiosis in chronic periodontitis: Key microbial players and interactions with the human host

A brief history of periodontics in the United States of America: Pioneers and thought‐leaders of the past, and current challenges

Effects of different periodontal treatments in changing the prevalence and levels of Archaea present in the subgingival biofilm of subjects with periodontitis: A secondary analysis from a randomized controlled clinical trial

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