Relationship between nutritional status and the Glasgow Prognostic Score in patients with colorectal cancer

Maurício, Sílvia Fernandes; Silva, Jacqueline Braga da; Bering, Tatiana; Correia, María Isabel Toulson Davisson

doi:10.1016/j.nut.2012.09.016

Cited by 47 publications

(30 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Excess weight, visceral fat and abdominal obesity appears to be more disturbing than subcutaneous fat, and any further increase in BMI confers increased risk of developing colorectal cancer 19 , which, however, has not been confirmed in other studies with this tool 8,15 . Some authors also use weight loss as a nutritional screening marker.…”

Section: Anthropometric Methodsmentioning

confidence: 84%

“…These results were also supported by our series of patients with esophageal, stomach and pan-creas tumors 8 . Moreover, in patients with esophageal or stomach cancer, SGA appears to be associated with the Glasgow Prognostic score (GPS) 19 . A study comparing PG-SGA with the Mini Nutritional Assessment (MNA) revealed that these tools seem appropriate to define elderly patients as malnourished 10 .…”

Section: Subjective Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Reliability of nutritional assessment in patients with gastrointestinal tumors

Poziomyck

Fruchtenicht

Kabke

et al. 2016

Rev. Col. Bras. Cir.

View full text Add to dashboard Cite

A B S T R A C TPatients with gastrointestinal cancer and malnutrition are less likely to tolerate major surgical procedures, radiotherapy or chemotherapy.In general, they display a higher incidence of complications such as infection, dehiscence and sepsis, which increases the length of stay and risk of death, and reduces quality of life. The aim of this review is to discuss the pros and cons of different points of view to assess nutritional risk in patients with gastrointestinal tract (GIT) tumors and their viability, considering the current understanding and screening approaches in the field. A better combination of anthropometric, laboratory and subjective evaluations is needed in patients with GIT cancer, since malnutrition in these patients is usually much more severe than in those patients with tumors at sites other than the GIT. Therefore, in the daily practice of oncology, the definition of an appreciable and simple to apply nutritional assessment tool is necessary to identify nutritional risk patients and thus determine the best approach and appropriate nutritional support 8 . The objective of this review is to present an overview of the methods and tools used to determine nutritional risk, considering the pros and cons when applied to patients with GIT cancer. METHODSWe systematically identified studies on nutritional status of patients with GIT cancer through the PubMed and MEDLINE databases. We researched articles published in the last ten years by combining the terms "nutritional assessment", "GI cancer", "gastrointestinal tract", "gastric cancer", "oesophageal cancer" and "pancreatic cancer". We considered for evaluation only complete articles with those terms in English or Portuguese. We identified additional articles from citations in the articles evaluated. RESULTS AND DISCUSSION General review of nutritional assessmentIt was in the 1950s that authors first published research related to nutritional assessment procedures. Subjective methodsIn 1980, Detsky et al. described the Subjective Global Assessment (SGA) used to assess preoperative patients with GIT tumors (n = 202) undergoing major surgical procedures; They have shown that SGA could be easily applied and considered it a valid and reliable method to estimate the surgical patients' nutritional status 12 .Other authors have published several articles supporting the SGA in determining nutritional status, which differed from other methods in considering not only changes in body composition, but also functional changes. In addition, SGA is a simple, inexpensive, non-invasive method and can be performed at bedside.Correct guidance on the SGA application is essential, since its accuracy depends on the observer's ability to detect subjectively significant nutritional changes 8,13,14 .Subsequently, the SGA has undergone modi- Wu et al. had higher incidence of complications and longer hospital stay the worse the level of SGA in patients undergoing major procedures for GIT cancer (mainly gastric) 18 . These results were also supported by our series o...

show abstract

Section: Anthropometric Methodsmentioning

confidence: 84%

Section: Subjective Methodsmentioning

confidence: 99%

Reliability of nutritional assessment in patients with gastrointestinal tumors

Poziomyck

Fruchtenicht

Kabke

et al. 2016

Rev. Col. Bras. Cir.

View full text Add to dashboard Cite

show abstract

“…Recently, studies have demonstrated an important association between nutritional depletion and inflammation in cancer patients [4][5][6]14,16,17,[19][20][21][22] , including GIT tumors. Since cancer patients are in a constant state of inflammation, and considering the role of this systemic inflammation in progressive weight loss and muscle mass, cancer cachexia can be identified by the presence and alteration of certain inflammatory markers [5][6][7] .…”

Section: Resultsmentioning

confidence: 99%

Inflammatory and nutritional statuses of patients submitted to resection of gastrointestinal tumors

Fruchtenicht

Poziomyck

Reis

et al. 2018

Rev. Col. Bras. Cir.

View full text Add to dashboard Cite

Objective: to evaluate the association between the nutritional and the inflammatory statuses of patients with cancer of the gastrointestinal tract undergoing surgical resection and to identify predictors of mortality in these patients. Methods: we conducted a prospective study of 41 patients with gastrointestinal tract cancer submitted to surgery between October 2012 and December 2014. We evaluated the nutritional status by subjective and objective methods. We assessed the inflammatory response and prognosis using the modified Glasgow Prognostic Score (mGPS), Neutrophil/Lymphocyte Ratio (NLR), Onodera Prognostic Nutritional Index (mPNI), Inflammatory-Nutritional Index (INI) and C-Reactive Protein/Albumin ratio (mPINI). Results: half of the patients were malnourished and 27% were at nutritional risk. There was a positive association between the percentage of weight loss (%WL) and the markers NLR (p=0.047), mPINI (p=0.014) and INI (p=0.015). Serum albumin levels (p=0.015), INI (p=0.026) and mPINI (p=0.026) were significantly associated with the PG-SGA categories. On multivariate analysis, albumin was the only inflammatory marker independently related to death (p=0.004). Conclusion: inflammatory markers were significantly associated with malnutrition, demonstrating that the higher the inflammatory response, the worse the PG-SGA (B and C) scores and the higher the %WL in these patients. However, further studies aimed at improving surgical outcomes and determining the role of these markers as predictors of mortality are required.

show abstract

“…En la actualidad, además de su componente de valoración del estado nutritivo, el IO se considera uno de los marcadores de la respuesta inflamatoria sistémica del paciente frente al tumor, ya que en dicha respuesta intervienen tanto la albúmina 9 como los linfocitos 10 . Por otra parte, también se ha descrito una correlación entre estado nutricional y respuesta inflamatoria en el carcinoma de colon 27 . Tanto la albuminemia como los linfocitos circulantes han sido analizados en trabajos previos como factores pronósti-cos de la evolución del cáncer colorrectal, bien de forma aislada 10,28 o en combinación con otras variables como el antígeno carcino-embrionario 8 y la proteína C reactiva (Indice de Glasgow) 5 .…”

Section: Discussionunclassified

Valor pronóstico del índice de Onodera en la supervivencia del cáncer colorrectal

Borda

Zozaya

et al. 2014

Anales Sis San Navarra

View full text Add to dashboard Cite

resuMenFundamento. El índice de Onodera (IO) combina los valores de los linfocitos circulantes y de la albúmina sérica y se ha utilizado como marcador del estado nutricional, postulándose recientemente en Japón y China su posible valor pronóstico en el cáncer colorrectal. Todavía no disponemos de datos sobre el valor predictivo del IO en una población occidental.Pacientes y métodos. Se revisaron 207 cánceres colorrectales resecados programada y consecutivamente, con intención curativa. Se calculó el IO pre-tratamiento mediante la fórmula: [10 x albúmina sérica (g/dl) + 0,005 x cifra de linfocitos circulantes/mm²]. Consideramos bajos los valores de IO menores de 40. Se efectuó un análi-sis univariable y multivariable de las curvas de supervivencia entre los casos con valores de IO menores de 40 (modelo de Cox, stepwise), todo ello en la serie global y en el estadio pTNM II.resultados. El seguimiento clínico tuvo una mediana de 81 meses (rango intercuartílico 60-96). Veintiséis pacientes (12,6%) presentaron un IO bajo (< 40). En el análisis multivariable, los pacientes con IO bajo mostraron unas curvas de supervivencia más desfavorables, tanto en la serie global: [p < 0,001; HR = 3,16; IC 95% = 1,67-5,94)] como en los 78 casos en estadio pTNM II: [p < 0,004; HR = 4,36; IC 95% = 1,61-11,76)].conclusiones. También en pacientes europeos, un índi-ce de Onodera pre-tratamiento bajo (< 40) tiene un valor predictivo independiente y desfavorable sobre la supervivencia en el cáncer colorrectal resecado, tanto en la serie global como en el estadio pTNM II.Palabras clave. Cáncer colorrectal. Pronóstico pretratamiento. Estadio pTNM II. Indice de Onodera. Índice pronóstico nutricional. aBstractBackground. Onodera's prognostic nutritional index (OPNI), which is calculated using total lymphocyte count and serum albumin level, has been used as a marker of nutritional status, with its potential prognostic value in colorectal cancer having recently been postulated in Japan and China. There is still no data on the predictive value of OPNI in a Western population.

show abstract

Relationship between nutritional status and the Glasgow Prognostic Score in patients with colorectal cancer

Abstract: Malnutrition is highly prevalent in patients with colorectal cancer. The nutritional status was associated with the GPS.

Cited by 47 publications

References 22 publications

Reliability of nutritional assessment in patients with gastrointestinal tumors

Reliability of nutritional assessment in patients with gastrointestinal tumors

Inflammatory and nutritional statuses of patients submitted to resection of gastrointestinal tumors

Valor pronóstico del índice de Onodera en la supervivencia del cáncer colorrectal

Contact Info

Product

Resources

About