Relationship Between Ox–LDL, Immune Cells, Atheroma Dimensions and Angiographic Measurements Assessed by Coronary Angiography and Intravascular Ultrasound

Ramos, Catarina; Napoleão, Patrícia; Ferreira, Rui Cruz; Fondinho, C.; Selas, Mafalda; Carmo, Miguel Mota; Crespo, A. M.; Pinheiro, Teresa J. T.

doi:10.5772/54084

Cited by 2 publications

(2 citation statements)

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“…Ox-low density lipoprotein dalam peredaran darah pasien PJK didapatkan lebih tinggi daripada jika dijumpai jejas di arteri koroner jantung. [15][16][17][18] Visualisasi secara langsung ox-LDL di dinding pembuluh darah adalah cara paling ideal untuk mengukur faktor kebahayaan aterosklerosis di PJK, tetapi cara memeriksa ini sulit dilakukan, memerlukan waktu dan tidak dapat dilakukan untuk kajian dengan skala luas, karena itu dilakukan pengukuran kadar ox-LDL dengan metode ELISA. 11,17 Penyakit jantung koroner adalah bermakna jika diberi batasan sebagai stenosis lebih dari 50% diameter pembuluh darah.…”

Section: Pendahuluanunclassified

OXIDIZED-LOW DENSITY LIPOPROTEIN DAN DERAJAT STENOSIS PENYAKIT JANTUNG KORONER (Oxidized-Low Density Lipoprotein and Stenosis Level in Coronary Artery Disease)

Sutamti¹,

Ap²,

Tjahjati³

2018

Indonesian J. Clin. Pathol. Med. Lab.

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Coronary artery disease is caused by atherosclerosis of the coronary arteries. Ox-LDL plays a role in atherosclerosis causing coronaryartery stenosis. There are differences in the research results on the relationship of ox-LDL levels and stenosis level of coronary arteryin patients with CAD. The aim of this study was to know the correlation between ox-LDL and stenosis level of coronary artery inCoronary Artery Disease (CAD). An observational study with cross sectional analytic approach was conducted on 37 patients with CADwho underwent coronary angiography in the Dr. Kariadi General Hospital and Telogorejo Hospital of Semarang, taken consecutivelyduring Febuary up to April 2014. The Ox-LDL levels were determined by sandwich ELISA and the stenosis levels were determined bycoronary angiography. The data were analyzed by non-parametric Spearman correlation test. Median of ox-LDL level in CAD patientswas 1666.8(846.15; 3324) pg/mL. The median of stenosis level was 80 (30;90)%. There was a significant correlation of ox-LDL leveland stenosis level (r=0.358; p=0.03) in CAD patients. Based on this study there was a weak positive correlation between ox-LDL leveland stenosis level in CAD patients.

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Section: Pendahuluanunclassified

OXIDIZED-LOW DENSITY LIPOPROTEIN DAN DERAJAT STENOSIS PENYAKIT JANTUNG KORONER (Oxidized-Low Density Lipoprotein and Stenosis Level in Coronary Artery Disease)

Sutamti¹,

Ap²,

Tjahjati³

2018

Indonesian J. Clin. Pathol. Med. Lab.

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“…Noninvasive identification of rupture-prone plaques would dramatically improve risk stratification of both symptomatic and asymptomatic patients. Therefore, associations between the expansive growth of the atherosclerotic plaque and soluble bioindicators may provide important information that enhances the precision of clinical and laboratory variables used to assess patients at risk of CAD or of plaque rupture (Ramos et al, 2013); (Hong et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Expansive Growth of Atherosclerotic Plaques Assessed by VH-IVUS - Association with TNF-α and OX-LDL Levels in Circulation

Ramos¹,

Napoleão²,

Fondinho³

et al. 2013

Proceedings of the International Congress on Cardiovascular Technologies

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The identification of a vulnerable plaque through the quantification of soluble biomarkers would improve the diagnosis and treatment of coronary artery disease. Inflammation and LDL oxidative modification have been implicated in CAD. Disease severity and plaque vulnerability have recently been associated to expansive plaque growth, rather than constrictive growth which results in vessel stenosis. Forty CAD patients were admitted prospectively. VH-IVUS was performed and TNF-α and ox-LDL were quantified in the serum and plasma, respectively. Expansive plaques characterized by large EEL diameters and preserved luminal measures were associated to STEMI patients. Larger EEL diameter (≥4.6 mm 2) was significantly associated to increases of TNF-α concentrations whereas larger plaque areas (≥13.0 mm 2) associated with ox-LDL increases in the circulation. Hence, TNF-α and ox-LDL may be indicators of plaque vulnerability.

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Relationship Between Ox–LDL, Immune Cells, Atheroma Dimensions and Angiographic Measurements Assessed by Coronary Angiography and Intravascular Ultrasound

Cited by 2 publications

References 50 publications

OXIDIZED-LOW DENSITY LIPOPROTEIN DAN DERAJAT STENOSIS PENYAKIT JANTUNG KORONER (Oxidized-Low Density Lipoprotein and Stenosis Level in Coronary Artery Disease)

OXIDIZED-LOW DENSITY LIPOPROTEIN DAN DERAJAT STENOSIS PENYAKIT JANTUNG KORONER (Oxidized-Low Density Lipoprotein and Stenosis Level in Coronary Artery Disease)

Expansive Growth of Atherosclerotic Plaques Assessed by VH-IVUS - Association with TNF-α and OX-LDL Levels in Circulation

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