Relationship between oxidative stress and lower urinary tract symptoms: results from a community health survey in Japan

Matsumoto, Teppei; Imai, Atsushi; Tanaka, Toshikazu; Hagiwara, K.; Konishi, Sakae; Okita, Kazutaka; Yamamoto, Hayato; Tobisawa, Yuki; Yoneyama, T.; Yoneyama, Takahiro; Hashimoto, Yasuhiro; Koie, Takuya; Nakaji, Shigeyuki; Οhyama, Chikara

doi:10.1111/bju.14535

Cited by 30 publications

(27 citation statements)

References 32 publications

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“…Lower urinary tract symptoms (LUTS) are among the most common urologic conditions in the older population . As the incidence of LUTS and frailty increases with age, the concept of frailty has been recognized as a key factor in older individuals with LUTS .…”

Section: Introductionmentioning

confidence: 99%

Relationship between frailty and lower urinary tract symptoms among community‐dwelling adults

Sato

Imai

Matsumoto

et al. 2019

LUTS

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Objectives: To evaluate the relationship between frailty and lower urinary tract symptoms (LUTS), the association of frailty and LUTS remains unclear. Methods: This cross-sectional study investigated LUTS and frailty in 710 individuals (249 men and 461 women, aged ≥60 years) who participated in the Iwaki Health Promotion Project between 2014 and 2015 in Hirosaki, Japan. Parameters of frailty were compared for individuals with mild and moderate to severe symptoms of LUTS. The International Prostate Symptom Score (IPSS) and Overactive Bladder Symptom Score (OABSS) were used to evaluate LUTS. Frailty was evaluated by the frailty phenotype (FP), modified frailty index (mFI), and frailty discriminant score (FDS). The influence of frailty on LUTS was investigated by multivariate logistic regression analyses.Results: Frailty parameters of age, renal function, and lower physical activity were significantly associated with severity of IPSS and OABSS. FP and mFI were significantly associated with severity of OABSS and IPSS, respectively. The FDS was significantly associated with severity of IPSS and OABSS. FP, mFI, and FDS were significantly associated with severity of nocturia. Multivariate logistic regression analyses revealed that FDS was independently associated with the severity of IPSS, OABSS, and nocturia, whereas FP and mFI were significantly associated with the severity of nocturia alone.Conclusions: Individuals with LUTS are potentially frailer than those without LUTS.Although the influence of frailty on LUTS is different depending on the measurement tool, attention for frailty is necessary for subjects with LUTS.

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Section: Introductionmentioning

confidence: 99%

Relationship between frailty and lower urinary tract symptoms among community‐dwelling adults

Sato

Imai

Matsumoto

et al. 2019

LUTS

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“…We retrospectively analyzed the clinical data of 1305 patients (Stone group) with the first episode of symptomatic urolithiasis who visited our hospitals from May 2010 to March 2018. The Ctrl group were selected from 2800 community‐dwelling individuals who underwent a comprehensive health survey between May 2006 and May 2016 in connection with the Iwaki Health Promotion Project, Hirosaki, Japan . The inclusion criteria for the Stone group were as follows: (i) imaging results, such as ultrasound, excretory urography or computed tomography, that led to a diagnosis of urolithiasis; (ii) availability of clinical and laboratory data at the time of stone diagnosis, comprising age, sex, BMI (kg/m 2 ), eGFR (mL/min/1.73 m 2 ), Alb (g/dL), UA (mg/dL), HTN, CVD and DM.…”

Section: Methodsmentioning

confidence: 99%

“…The Ctrl group were selected from 2800 community-dwelling individuals who underwent a comprehensive health survey between May 2006 and May 2016 in connection with the Iwaki Health Promotion Project, Hirosaki, Japan. [10][11][12][13][14][15][16] The inclusion criteria for the Stone group were as follows: (i) imaging results, such as ultrasound, excretory urography or computed tomography, that led to a diagnosis of urolithiasis; (ii) availability of clinical and laboratory data at the time of stone diagnosis, comprising age, sex, BMI (kg/m 2 ), eGFR (mL/min/1.73 m 2 ), Alb (g/dL), UA (mg/dL), HTN, CVD and DM. The exclusion criterion for the study was insufficient information against the criteria.…”

Section: Study Design and Patient Selectionmentioning

confidence: 99%

STone Episode Prediction: Development and validation of the prediction nomogram for urolithiasis

et al. 2020

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Objectives To develop and validate a nomogram predicting the occurrence of a stone episode, given the lack of such predicting risk tools for urolithiasis. Methods We retrospectively analyzed 1305 patients with urolithiasis and 2800 community‐dwelling individuals who underwent a comprehensive health survey. The STone Episode Prediction nomogram was created based on data from the medical records of 600 patients with urolithiasis and 1300 controls, and was validated using a different population of 705 patients with urolithiasis and 1500 controls. Logistic regression analysis was used to construct a model to predict the potential candidate for a stone episode. The predictive ability of the model was evaluated using the results of the area under the receiver operating characteristics curve (area under the curve). Results Age, sex, diabetes mellitus, renal function, serum albumin, and serum uric acid were found to be significantly associated with urolithiasis in the training set and were included in the STone Episode Prediction nomogram. The optimal cut‐off value for the probability of a stone episode using the nomogram was >28% with a sensitivity of 79%, a specificity of 76%, and area under the curve of 0.860. In the validation test, area under the curve for the detection of urolithiasis was 0.815 with a sensitivity of 81% and specificity of 63%. Conclusions Herein, we developed and validated the STone Episode Prediction nomogram that can predict a potential candidate for an episode of urolithiasis. This nomogram might be beneficial for the first step in stone screening in individuals with lifestyle‐related diseases.

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“…Matsumoto et al. investigated the possible relationship between some markers of oxidative stress and LUTS in a population of community‐living subjects participating in a health promotion project. As markers of oxidative stress, they used 8‐OHdG (urine) and AGEs (skin autofluorescence), while structured questionnaires were used to assess LUTS.…”

mentioning

confidence: 99%

Oxidative stress and lower urinary tract symptoms: cause or consequence?

Andersson

2019

BJU International

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Relationship between oxidative stress and lower urinary tract symptoms: results from a community health survey in Japan

Abstract: We observed a significant association between AGE levels and nocturia score > 1. Further research is necessary to clarify a possible causal relationship between oxidative stress and nocturia.

Cited by 30 publications

References 32 publications

Relationship between frailty and lower urinary tract symptoms among community‐dwelling adults

Relationship between frailty and lower urinary tract symptoms among community‐dwelling adults

STone Episode Prediction: Development and validation of the prediction nomogram for urolithiasis

Oxidative stress and lower urinary tract symptoms: cause or consequence?

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