Relationship between oxidative stress‐related biomarkers and antioxidant status with asthma and atopy in young adults: a population‐based study

García-Larsen, Vanessa; Chinn, Susan; Rodrigo, Ramón; Amigo, Hugo; Bustos, Patricia; Rona, Roberto J.

doi:10.1111/j.1365-2222.2008.03163.x

Cited by 19 publications

(7 citation statements)

References 37 publications

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“…Furthermore, association with advanced duration and stage of COPD has been reported [34]. Serum UA levels were not significantly associated with lung function and symptoms in patients with asthma [35].…”

Section: Discussionmentioning

confidence: 99%

Gender-Specific Association of Serum Uric Acid and Pulmonary Function: Data from the Korea National Health and Nutrition Examination Survey

et al. 2021

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Background and Objectives: Hyperuricemia is associated with several comorbidities. The association between uric acid (UA) and pulmonary function is still a controversial issue. This study evaluated the gender-specific association of serum UA and pulmonary function. Materials and Methods: A total of 3177 (weighted n = 19,770,902) participants aged 40 years or older were selected from the 2016 Korean National Health and Nutrition Examination Survey and included. Results: Female participants with hyperuricemia were older than participants with normouricemia. Body mass index (BMI), mean arterial pressure (MAP), hemoglobin A1c (HbA1c), and estimated glomerular filtration rate (eGFR) were significantly associated with UA levels in both males and females. Hyperuricemia and increase in UA quartile were significantly associated with decreased forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) in females after adjustment for age, income, region, education, marital status, alcohol consumption, smoking, BMI, MAP, HbA1c, and eGFR. There was no significant association between UA levels and lung function in males. After additional adjustment for respiratory disease including pulmonary tuberculosis, asthma, and lung cancer, the association between hyperuricemia and decreased FEV1 and FVC in females was revealed. Conclusions: Hyperuricemia was associated with decreased FVE1 and FVC in the female general population.

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Section: Discussionmentioning

confidence: 99%

Gender-Specific Association of Serum Uric Acid and Pulmonary Function: Data from the Korea National Health and Nutrition Examination Survey

et al. 2021

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“…Exhaled breath condensate and broncho-alveolar lavage samples from affected individuals have been shown to contain increased levels of 8-isoprostane, and other well established maker of oxidative stress 113, 114 . Peripherally, additional biomarkers of oxidative stress (superoxide anion generation, lipid peroxidation, total nitrates/nitrites, total protein carbonyls, and total protein sulfhydrils) may be increased, concomitant with decreased levels of specific anti-oxidants (superoxide dismutase, catalase activity, glutathione, and glutathione peroxidase activity, etc) 112, 115, 116 . It remains unclear if increased levels of oxidative stress observed in asthmatic individuals is a cause of disease, or rather a result of ongoing inflammation in the airways, which itself produces reactive oxygen species.…”

Section: Non-immunologic Mechanismsmentioning

confidence: 99%

Pathogenesis and Disease Mechanisms of Occupational Asthma

Lummus

Wisnewski

Bernstein

2011

Immunology and Allergy Clinics of North America

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“…That study demonstrated that there was no relationship between plasma UA and lung function 12. However, these relationships were only investigated in a population of young adults, and the association between sUA levels and pulmonary function in the general population remains to be elucidated.…”

Section: Introductionmentioning

confidence: 96%

The Relationship between Serum Uric Acid and Spirometric Values in Participants in a Health Check: The Takahata Study

Aida¹,

Shibata²,

Osaka³

et al. 2011

Int. J. Med. Sci.

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Background: Tissue hypoxia induces the degradation of adenosine triphosphate, resulting in the production of uric acid (UA). Patients with chronic obstructive pulmonary disease (COPD) have been reported to have high serum levels of UA (sUA), compared with control subjects. However, the relationship between sUA levels and spirometric measures has not been investigated in detail in a general population.Methods: Subjects aged 40 years or older (n = 2,917), who had participated in a community-based annual health check in Takahata, Japan, in 2004 and 2005, were enrolled in the study. These subjects performed spirometry, their blood pressure was measured, and a blood sample was taken.Results: sUA levels were significantly higher in males than in females. Percent predicted forced vital capacity [FVC %predicted] (r = -0.13) and forced expiratory volume in 1 s [FEV1 %predicted] (r = -0.118) were inversely correlated with sUA levels in females but not in males. Univariate regression analysis indicated that age, body mass index (BMI), ethanol intake, mean blood pressure (BP), and serum creatinine (sCr) were significantly associated with sUA levels in males. In females, age, BMI, mean BP, hemoglobin A1c, sCr, FVC %predicted, and FEV1 %predicted were significantly associated with sUA levels. Multiple linear regression analysis showed that for both genders, FVC %predicted and FEV1 %predicted were predictive for sUA levels, independently of the other clinical parameters. Subjects with lung restriction had higher sUA levels than subjects without lung restriction. In addition, subjects with moderate and severe airflow limitation had higher sUA levels than subjects without airflow limitation or those with mild airflow limitation.Conclusion: FVC %predicted and FEV1 %predicted were significantly associated with sUA levels in a general population.

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Relationship between oxidative stress‐related biomarkers and antioxidant status with asthma and atopy in young adults: a population‐based study

Abstract: The levels of oxidative stress-related biomarkers and antioxidant status in plasma may not be related to asthma in the general population in the absence of more severe symptoms or exacerbations.

Cited by 19 publications

References 37 publications

Gender-Specific Association of Serum Uric Acid and Pulmonary Function: Data from the Korea National Health and Nutrition Examination Survey

Gender-Specific Association of Serum Uric Acid and Pulmonary Function: Data from the Korea National Health and Nutrition Examination Survey

Pathogenesis and Disease Mechanisms of Occupational Asthma

The Relationship between Serum Uric Acid and Spirometric Values in Participants in a Health Check: The Takahata Study

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