Relationship between oxidized fibrinogen and hemostasis disturbances and endothelial dysfunction in myocardial infarction

Ragino, Yu. I.; Baum, V.A.; Polonskaya, Yа. V.; Sadovski, E. V.; Baum, S. R.; Nikitin, Yu. P.

doi:10.1007/s10517-008-0104-8

Cited by 3 publications

(4 citation statements)

References 10 publications

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“…However, the increased levels of plasma fibrinogen were implied not only with the long-term disorder of glycolipid metabolism but also with long time standing of low-grade systematic inflammatory reaction and atherosclerotic plaques progress in these settings [ 10 , 41 ]. In addition, impaired fibrinolysis or oxidative fibrinogen may exacerbate preexisting CAD and potentiate its evolution [ 9 ]. Besides, the formation of thrombi at the site of atherosclerotic lesions plays a central role in atherothrombosis, plaque evolution, and various acute cardiac events [ 3 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

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Association of Fibrinogen with Severity of Stable Coronary Artery Disease in Patients with Type 2 Diabetic Mellitus

Liu

Luo

et al. 2014

Disease Markers

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Background. Some studies have suggested a relation of plasma fibrinogen to the severity of coronary artery disease (CAD). However, whether plasma fibrinogen can predict the presence and severity of CAD in patients with diabetes mellitus has not been determined. Methods. A total of consecutive 373 diabetic patients with typical angina pectoris who received coronary angiography were enrolled and classified into three groups by tertiles of Gensini score (GS, low group <8; intermediate group 8~28; high group >28). The relationship between fibrinogen and GS was evaluated. Results. There were correlations of fibrinogen with hemoglobin A1c, C-reactive protein, and GS (r = 0.17, r = 0.52, and r = 0.21, resp.; all P < 0.001). Area under the receivers operating characteristic curve of fibrinogen was 0.62 (95% CI 0.56–0.68, P < 0.001) for predicting a high GS. Multivariate analysis suggested that plasma fibrinogen was an independent predictor of a high GS for diabetic patients (OR = 1.40, 95% CI 1.04–1.88, and P = 0.026) after adjusting for traditional risk factors of CAD. Conclusions. The present data indicated that plasma fibrinogen, a readily measurable systematic inflammatory marker, appeared to be an independent predictor for the severity of CAD in diabetic patients.

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Section: Discussionmentioning

confidence: 99%

“…Moreover, few of them confirmed a correlation of high circulating plasma fibrinogen with adverse outcome in patients with CAD [ 1 , 4 , 6 ]. Meanwhile, recent observations indicated a relationship between fibrinogen and atherosclerotic plaque progress in patients with acute coronary syndrome (ACS) and stable CAD [ 7 – 9 ].…”

Section: Introductionmentioning

confidence: 99%

Association of Fibrinogen with Severity of Stable Coronary Artery Disease in Patients with Type 2 Diabetic Mellitus

Liu

Luo

et al. 2014

Disease Markers

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“…In parallel, with obesity-related oxidative stress, different biomolecules, including lipids, can be damaged [69]. LDL and proteins (e.g., fibrinogen) are modified to oxidized particles, which provoke all stages of the atherosclerosis process, starting with endothelial dysfunction, leukocyte activation, foam cell formation, and smooth muscle cell migration and proliferation, thus resulting in platelet adhesion and aggregation [70,71]. Oxidized LDL was also shown to be associated with the incidence of MS [72,73], which reflects the complex interlinkage of the described processes in their effects on CVD development.…”

Section: Cardiometabolic Conditionsmentioning

confidence: 99%

Socio-Demographic, Lifestyle, and Cardiometabolic Characteristics Associated with Low-Grade Systemic Inflammation in Russian Adult Population

et al. 2023

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Mortality from cardiovascular diseases (CVDs) is higher in Russia compared to other European countries. High-sensitivity C-reactive protein (hs-CRP) is a biomarker of inflammation, and its elevated levels indicate increased CVD risks. We aim to describe the prevalence of low-grade systemic inflammation (LGSI) and the associated factors in a Russian population. The Know Your Heart cross-sectional study was conducted in Arkhangelsk, Russia in 2015–2017 with a population sample aged 35–69 years (n = 2380). LGSI was defined as hs-CRP ≥ 2 and < 10 mg/L, and its associations with socio-demographic, lifestyle, and cardiometabolic characteristics were analyzed. The prevalence of LGSI (age-standardized to European Standard Population 2013) was 34.1% (33.5% in men and 36.1% in women). In the total sample, the increased odds ratios (ORs) of LGSI were associated with abdominal obesity (2.1), smoking (1.9), dyslipidemia (1.5), pulmonary diseases (1.4), and hypertension (1.3); the decreased ORs were in women (0.6) and in married participants (0.6). In men, the ORs were higher with abdominal obesity (2.1), smoking (2.0), CVDs (1.5), and hazardous drinking (1.5); in women—with abdominal obesity (4.4) and pulmonary diseases (1.5). In conclusion, one-third of the adult population in Arkhangelsk had LGSI. Abdominal obesity was the strongest LGSI correlate in both sexes, while the profiles of other associated factors were different between men and women.

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“…Thus, it is necessary to determine if some other risk factors may contribute to the formation and progression of CAD. Several studies have shown that fibrinogen is related to increased cardiovascular (CV) risk 12 and plaque progression in patients with acute coronary syndrome and stable angina [13][14][15] . The AtheroGene study 16 investigated 1806 patients with documented CAD and stable angina pectoris concluded that high fibrinogen and C reactive protein (CRP) values were predictive for future CV risk, but did not provide additional information on top of traditional risk factors.…”

Section: Introductionmentioning

confidence: 99%

Hyperhomocysteinemia and inflammatory biomarkers are associated with higher clinical SYNTAX score in patients with stable coronary artery disease

Djuric

Mladenović

Spasić

et al. 2021

VSP

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Background/Aim. Previous studies have confirmed a positive correlation between homocysteine levels and a greater risk for acute coronary syndrome and stroke, but there are no available data to support an association between homocysteine and inflammatory markers and the severity of coronary artery disease according to Clinical SYNTAX score in patients with stable angina. The aim was to determine the association between homocysteine and inflammatory biomarkers levels: interleukin 6, high sensitive C reactive proteine, fibrinogen, erythrocyte sedimentation rate and severity of coronary artery disease according to Clinical SYNTAX score. Methods. Eighty-two patients with stable angina pectoris (average age 65 ± 8 years, 28.9% females) underwent coronary angiography and were divided into three groups according to Clinical SYNTAX score: the group I < 22 (39 patients), the group II 23-32 (16 patients), the group III > 33 (27 patients). The severity and complexity of coronary artery disease were calculated by Clinical SYNTAX score, multiplying the SYNTAX score with the modified ACEF score, based on the patients' left ventricular ejection fraction, age and creatinine clearance (derived with Cockcroft-Gault equation). Results. Homocysteine levels were significantly higher in patients with high Clinical SYNTAX (the group I: median (IQR): 10.20 (3.97), the group II: 10.45 (5.77), the group III: 14.70 (7.50), p = 0.005). Patients in group III had significantly higher homocysteine levels compared to group I (p = 0.001). We also found positive association between inflammatory biomarkers (interleukin 6, high sensitive C reactive proteine, fibrinogen, erythrocyte sedimentation rate) and severity of coronary artery disease according to Clinical SYNTAX score (p = 0.017, 0.001, 0.032, 0.049 respectively). We detected significantly lower plasma levels of Vitamin B12 in group III and group II in comparison with group I (the group I: median (IQR): 238 (160), the group II: 171 (160), the group III: 172 (102), p = 0.022), which indicate its important role in homocysteine metabolism. Conclusion. Elevated plasma levels of homocysteine, interleukin 6, high sensitive C reactive proteine, fibrinogen, erythrocyte sedimentation rate were detected in patients with high Clinical SYNTAX score (> 33). Our results showed that hyperhomocysteinemia and some inflammatory biomarkers can predict more severe and extent coronary artery disease in stable angina patients. hiperhomocisteinemija i pojedini inflamacijski biomarkeri mogu ukazati na prisustvo ozbiljnije i ekstenzivnije koronarne arterijske bolesti kod pacijenata sa stabilnom anginom pektoris. Ključne reči: koronarna arterijska bolest, homocistein, inflamacijski biomarkeri, klinički SINTAKS skor.

show abstract

Relationship between oxidized fibrinogen and hemostasis disturbances and endothelial dysfunction in myocardial infarction

Cited by 3 publications

References 10 publications

Association of Fibrinogen with Severity of Stable Coronary Artery Disease in Patients with Type 2 Diabetic Mellitus

Association of Fibrinogen with Severity of Stable Coronary Artery Disease in Patients with Type 2 Diabetic Mellitus

Socio-Demographic, Lifestyle, and Cardiometabolic Characteristics Associated with Low-Grade Systemic Inflammation in Russian Adult Population

Hyperhomocysteinemia and inflammatory biomarkers are associated with higher clinical SYNTAX score in patients with stable coronary artery disease

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