Relationship between p21 and p53 Expression, Human Papilloma Virus Infection and Malignant Transformation in Sinonasal-inverted Papilloma

Katori, Hideaki; Nozawa, Akio; Tsukuda, Mamoru

doi:10.1016/j.clon.2005.11.001

Cited by 53 publications

(60 citation statements)

References 17 publications

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“…Furthermore, there is little information regarding the expression of these regulatory molecules in IP and paranasal SCC. Katori et al [32] indicated that significantly increased staining of p21 and p53 was observed in IP with severe dysplasia, IP with carcinoma and invasive carcinoma compared with control nasal mucosa. They suggested that testing for p21 and p53 may help to screen out papilloma lesions with a potential for dysplasia or carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…Recent data suggested of the biologic significance of Ki-67 as a proliferative index in paranasal tumors. Katori et al [32] investigated the Ki-67 index in IP and invasive SCC and found significantly higher Ki-67 in IP with severe dysplasia, IP with carcinoma and SCC compared with IP [33] showed that the p53 scores of SCC areas and Ki-67 index were significantly larger than those of IPs without SCC/DL or those of NPs. This study clearly demonstrated that Ki-67 proliferative index values were significantly higher in the paranasal SCC compared with the values in IPs.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of P53, P63, P21, P27, Ki-67 in Paranasal Sinus Squamous Cell Carcinoma and Inverted Papilloma

Öncel

Cosgul

Çallı

et al. 2011

Indian J Otolaryngol Head Neck Surg

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Using a molecular genetic approach, we try to confirm the molecular alterations of inverted papilloma and clarify its status as a putative precursor lesion of sinonasal squamous cell carcinoma. To better understand its genetics, we investigated the immunohistochemical protein expression patterns of cell-cycle-regulators p53, p63, p21, p27 and proliferation marker Ki-67 in 22 inverted papilloma and 9 squamous cell carcinoma of the sinonasal tract. Significantly elevated levels of p53 and p63 in squamous cell carcinoma of sinonasal tract compared with inverted papilloma were revealed. Ki-67-stained neoplastic cell nuclei were found in a significantly higher percentage of squamous cell carcinoma of sinonasal tract than in inverted papilloma, whereas no variation of p21 and p27 expression was identified. This work first examined the immunohistochemical overexpression of p63 in sinonasal inverted papilloma and squamous cell carcinoma. In conclusion, this is a first study shedding light on the expression of p63 in tumors of paranasal sinuses.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of P53, P63, P21, P27, Ki-67 in Paranasal Sinus Squamous Cell Carcinoma and Inverted Papilloma

Öncel

Cosgul

Çallı

et al. 2011

Indian J Otolaryngol Head Neck Surg

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show abstract

“…An immunohistochemical study has shown increased expression of p21 and p53 in inverted papillomas associated with dysplasia and squamous cell carcinoma [8]. HPV family 6/11 and 16/18 DNA has been observed in inverted papilloma associated with severe dysplasia and squamous cell carcinoma and HPV infection may be an early step in the process of malignant transformation [9].…”

Section: Discussionmentioning

confidence: 99%

“…HPV family 6/11 and 16/18 DNA has been observed in inverted papilloma associated with severe dysplasia and squamous cell carcinoma and HPV infection may be an early step in the process of malignant transformation [9]. An increased incidence of dysplasia has been observed in inverted papillomas positive for HPV family 6/11 and 16/18 DNA while decreased expression of p21 and p53 has been observed in HPV 16/18 positive inverted papillomas compared with those which are HPV 16/18 negative [8].…”

Section: Discussionmentioning

confidence: 99%

Common Head and Neck Cases in Our Consultation Referrals: Diagnostic Dilemmas in Inverted Papilloma

Sandison

2009

Head and Neck Pathol

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Papillomas of the nose and paranasal sinuses comprise three morphologically distinct variants-everted papilloma, inverted papilloma and cylindric cell papilloma in descending order of frequency. Recurrence of everted papilloma is unusual and malignant change does not occur. However, inverted papilloma is associated with multiple recurrences and malignant change. The histology of low grade squamous cell carcinoma of the nose may mimic that of inverted papilloma and low grade squamous cell carcinoma may coexist with inverted papilloma and be present in the same biopsy material. There is a high index of suspicion of concomitant malignancy in the presence of severe atypia or hyperkeratosis. Columnar cell papillomas are also associated with an increased risk of malignancy but the rarity of these lesions makes accurate assessment of malignant potential difficult. The most common diagnostic dilemma for pathologists referring cases for second opinion is the recognition of low grade malignancy versus benign inverted papilloma at presentation and in lesions which recur. Recent studies have addressed the requirement for histological parameters to predict the clinical course of these lesions and new molecular markers are being applied to tissue diagnosis. The early recognition and treatment of malignancy associated with inverted papilloma is key to decreased morbidity and improved patient survival and forms the basis of this discussion.

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“…In our study, the immunoexpression of p53 was significantly lower in the HPV--positive group compared to the HPV-negative group. Altavilla et al [26] and Katori et al [27] also showed decreased or no p53 immunoexpression in the HPV--positive group compared to the HPV-negative group of inverted papillomas. Our results support the idea of neutralization of the p53 gene suppressor pathways by HPV proteins.…”

Section: Discussionmentioning

confidence: 99%

Effect of human papillomavirus on cell cycle-related proteins p16INK4A, p21waf1/cip1, p53 and cyclin D1 in sinonasal inverted papilloma and laryngeal carcinoma. An <i>in situ</i> hybridization study

Stasikowska-Kanicka

Wągrowska-Danilewicz²,

Danilewicz³

2011

Folia Histochem Cytobiol.

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Human papillomavirus (HPV) infection is implicated as an important risk factor in the development of head and neck cancers. Many studies focusing on the relationships between HPV infection and cell cycle proteins immunoexpression in laryngeal lesions have provided contradictory results. The aim of this study was to evaluate the relationships between HPV DNA presence and p16INK4a, p21waf1/cip1, p53 and cyclin D1 immunoexpression in heterogenous HPV-positive and HPV-negative groups of laryngeal cancers and inverted papillomas. The HPV DNA expression was detected using an in situ hybridization method and immunoexpression of p16INK4a, p21waf1/cip1, p53 and cyclin D1 using immunohistochemistry. The immunoexpression of p21waf1/ /cip1 and p53 proteins was lower in the HPV-positive group compared to the HPV-negative group, although only the difference of p53 staining was statistically significant. The immunoexpression of p16INK4a and cyclin D1 was significantly increased in the HPV-positive group compared to the HPV-negative group. The increased immunoexpression of p16INK4a and cyclin D1, and the lower immunoexpression of p21waf1/cip1 and p53 in the HPV-positive group compared to the HPV-negative group, supports the hypothesis that HPV may play an important role in cell cycle dysregulation.

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Relationship between p21 and p53 Expression, Human Papilloma Virus Infection and Malignant Transformation in Sinonasal-inverted Papilloma

Cited by 53 publications

References 17 publications

Evaluation of P53, P63, P21, P27, Ki-67 in Paranasal Sinus Squamous Cell Carcinoma and Inverted Papilloma

Evaluation of P53, P63, P21, P27, Ki-67 in Paranasal Sinus Squamous Cell Carcinoma and Inverted Papilloma

Common Head and Neck Cases in Our Consultation Referrals: Diagnostic Dilemmas in Inverted Papilloma

Effect of human papillomavirus on cell cycle-related proteins p16INK4A, p21waf1/cip1, p53 and cyclin D1 in sinonasal inverted papilloma and laryngeal carcinoma. An <i>in situ</i> hybridization study

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