Relationship between particle shape and some process variables in high shear wet granulation using binders of different viscosity

Cavinato, Mauro; Franceschinis, Erica; Cavallari, S; Realdon, Nicola; Santomaso, Andrea C.

doi:10.1016/j.cej.2010.08.029

Cited by 26 publications

(8 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This aids granulation and is a valid explanation for the results shown in the Figure 13 (b) where mass increase was highest at low viscosity CMC solutions for starch and lactose. At high viscosity, more time was needed for the binder to seep to the surface of the nucleus which in turn leads to less granulation [22].…”

Section: Effect Of the Binder Viscosity On Growth Kineticsmentioning

confidence: 99%

Growth kinetics of nuclei formed from different binders and powders in vertical cylindrical mixing devices

Baghdadi

Shah

Albadarin

et al. 2018

Chemical Engineering Research and Design

View full text Add to dashboard Cite

Granulation is the process of forming large aggregates from fine particles using a high shear mixer. This method is used in several industries from pharmaceuticals to chemical and fertilizer production. This research will study the effect of four process variables: speed of mixer rotation in the range 100 to 200rpm, powder bed mass (25 to 40g), mass of the initial nucleus (0.6 to 2g), and binder viscosity (water, carboxymethyl cellulose (CMC) solutions with concentrations in the range 0.5 to 20g/L) on single nuclei growth kinetics in low mixing devices. The powders under study were: lactose, tea, sugar, starch, and limestone. The results show the initial size of nuclei, the initial mass of the powder bed and binder viscosity and speed of rotation all influence the rate of nuclei growth. Analysis of the stokes deformation number of the nuclei show that growth rate of the nuclei decreases as the deformation number increases whilst the percentage gain in mass of the nuclei increases with increasing deformation number. The binder viscosity was shown to have the biggest influence of the growth rate of the nuclei. Results show that difference in powder density also has an effect on the growth kinetics of nuclei. The initial position of nuclei was also shown to influence the nuclei growth rate; the closer the starting position of the nuclei to the wall of the vessel the slower the growth rate.

show abstract

Section: Effect Of the Binder Viscosity On Growth Kineticsmentioning

confidence: 99%

Growth kinetics of nuclei formed from different binders and powders in vertical cylindrical mixing devices

Baghdadi

Shah

Albadarin

et al. 2018

Chemical Engineering Research and Design

View full text Add to dashboard Cite

show abstract

“…Agarwal et al showed that the important factors that can determine the physical properties of self-emulsifying powder such as flowability are particle size, specific surface area, and the type and amount of solidification excipient [237]. In addition, the mechanisms of granule formation and comparison of the binding performance between pure water with or without SEDDS was studied by Cavinato et al [238]. This report presented that liquid SEDDS was a better binder solution for more spherical granules with a narrower size distribution than water when impeller speed was low.…”

Section: Powder and Granulesmentioning

confidence: 99%

Current Status of Supersaturable Self-Emulsifying Drug Delivery Systems

Park

Kim

2020

Pharmaceutics

View full text Add to dashboard Cite

Self-emulsifying drug delivery systems (SEDDSs) are a vital strategy to enhance the bioavailability (BA) of formulations of poorly water-soluble compounds. However, these formulations have certain limitations, including in vivo drug precipitation, poor in vitro in vivo correlation due to a lack of predictive in vitro tests, issues in handling of liquid formulation, and physico-chemical instability of drug and/or vehicle components. To overcome these limitations, which restrict the potential usage of such systems, the supersaturable SEDDSs (su-SEDDSs) have gained attention based on the fact that the inclusion of precipitation inhibitors (PIs) within SEDDSs helps maintain drug supersaturation after dispersion and digestion in the gastrointestinal tract. This improves the BA of drugs and reduces the variability of exposure. In addition, the formulation of solid su-SEDDSs has helped to overcome disadvantages of liquid or capsule dosage form. This review article discusses, in detail, the current status of su-SEDDSs that overcome the limitations of conventional SEDDSs. It discusses the definition and range of su-SEDDSs, the principle mechanisms underlying precipitation inhibition and enhanced in vivo absorption, drug application cases, biorelevance in vitro digestion models, and the development of liquid su-SEDDSs to solid dosage forms. This review also describes the effects of various physiological factors and the potential interactions between PIs and lipid, lipase or lipid digested products on the in vivo performance of su-SEDDSs. In particular, several considerations relating to the properties of PIs are discussed from various perspectives.Pharmaceutics 2020, 12, 365 2 of 57 intraluminal supersaturation and the biorelevance of supersaturation assays will be addressed. Finally, we will make suggestions for the successful development of su-SEDDs.There are many review articles that give useful information about the nature and application of supersaturable drug delivery systems or conventional SEDDSs. However, these reviews cover only a limited range of su-SEDDSs. Therefore, this review, which includes the current status of technology focused only on su-SEDDSs, is a valuable addition to the previous review literature because no review article currently covers such a wide range of su-SEDDSs. Conventional Solubilized SEDDSsThere has been a steady increase in the number of new drug candidates (almost 40%) that are highly hydrophobic and poorly water-soluble. The oral bioavailability of poorly water-soluble drugs is hindered by low solubility and slow dissolution in the aqueous environment of the GIT. Thus, it is a great challenge for pharmaceutical scientists to overcome the inherent slow dissolution and poor oral absorption of hydrophobic drugs [1][2][3][4]. SEDDSs have emerged as a promising approach to improving the biopharmaceutical performance of hydrophobic drugs by enhancing their bioavailability [5,6].An SEDDS is a pre-concentrate composed of a drug, oils, surfactants, and sometimes co-solvents and/or co-surfactan...

show abstract

“…enhanced solubility and bioavailability) (Atef and Belmonte, 2008;Balakrishnan et al, 2009;Tang et al, 2008). A versatile way to obtain solid forms is the high shear wet granulation (HSWG) process (Cavinato et al, 2010a, Cavinato et al, 2010bCavinato et al, 2011). Some studies have also demonstrated that it is possible to incorporate a self-emulsifying system into microcrystalline cellulose using extrusion/spheronization and high shear granulation processes (Newton et al, 2001;Franceschinis et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Influence of process variables on the properties of simvastatin self-emulsifying granules obtained through high shear wet granulation

et al. 2015

View full text Add to dashboard Cite

Improvements of the oral bioavailability of lipophilic drugs can be obtained using lipidic formulations such as the\ud self-emulsifying drug delivery systems. The high shear wet granulation (HSWG), using microemulsions as\ud binder, is a viable process to produce self-emulsifying granules. However only few information are present in\ud the literature on the effect of process variables on the properties of the granules obtained with these binders.\ud Consequently, this article compares the effects of some relevant experimental variables (impeller speed and\ud massing time) on thefinal technological and pharmaceutical properties of the granules produced using simple\ud water, or alternatively, a microemulsion as binder and containing simvastatin (SV) as model drug. The effects\ud of the variables were determined by evaluating the granule median diameter, their particle size distribution,\ud roundness, disintegration time and dissolution rate of SV. Results clearly demonstrated that the\ud microemulsion-based process was less sensitive tooperating conditions than the water-based process.\ud With microemulsion the nucleation process and growth regimes were more difficult to control, resulting\ud in products with broader PSDs. At the same operatingconditions microemulsion-based granules were\ud more brittle but rounder and showed smaller median diameter compared to water-based granules. The\ud dissolution rate of simvastatin was not significantly affected by the operating conditions

show abstract

Relationship between particle shape and some process variables in high shear wet granulation using binders of different viscosity

Cited by 26 publications

References 23 publications

Growth kinetics of nuclei formed from different binders and powders in vertical cylindrical mixing devices

Growth kinetics of nuclei formed from different binders and powders in vertical cylindrical mixing devices

Current Status of Supersaturable Self-Emulsifying Drug Delivery Systems

Influence of process variables on the properties of simvastatin self-emulsifying granules obtained through high shear wet granulation

Contact Info

Product

Resources

About