Relationship between peculiarities of atrial fibrillation, body mass index and adipokines levels

Abstract

Aim:To assess the value of body mass index (BMI) and adipokine levels in predicting development of atrial fibrillation (AF) in the general population. Methods: Three hundred and ninety eight patients were examined for the presence of phenotype metabolically healthy obesity (MHO), according to the Wildman criteria; adipokine levels were assessed by enzyme immunoassay method; AF was assessed by electrocardiography (ECG) and/or by ECG diurnal monitoring. Results: Obesity (group 1) and overweight (group 2) was present in 23.7% and 42.0% of participants; while 21.1% were normal body weight (group 3) and 13.1% had a BMI < 19.9 kg/m² (group 4). Phenotype MHO was detected in 19.6% patients. At follow-up, 32.4% of participants developed AF. Adiponectin levels were significantly higher in MHO patients as compared to metabolically unhealthy patients with abdominal obesity (AO). High molecular weight adiponectin (HMVAN) levels were significantly decreased in patients of groups 1 and 4, as compared to groups 2 and 3. Correlation between AF and HMWAN was determined by regressive analysis in patients of 1st and 4th groups (β = -0.24, P = 0.003 and β = -0.26, P = 0.002, respectively). Conclusion: The probability of developing AF increases with AO and decreased BMI, which is accompanied by a change in HMVAN levels. In MHO patients, the probability of AF developing is identical with persons having normal BMI. Key words:Atrial fibrillation, obesity, metabolically healthy obesity, metabolically unhealthy obesity, serum leptin, high-molecular-weight adiponectin ABSTRACTArticle history:

Association of adiponectin gene expression with atrial fibrillation in a Pakistani populace

“…The occurrence of AF was independently correlated with adiponectin levels 5 . Likewise, paroxysmal AF patients < 65 years old with greater levels of adiponectin may be more at risk for recurrent AF following catheter ablation, according to earlier prospective studies 4 .…”

Introduction of the special issue “Atherosclerosis and Related Diseases”

“…Bilovol et al [8] from Ukraine aimed to evaluate the probability of developing atrial fibrillation depending on the body mass index and adipokines levels in the general population. The obtained results indicate that while obesity was associated with different metabolic, hormonal and hemodynamic changes that affect heart muscle causing its structural and functional changes, the same changes were present in patients with body weight deficit, associated with similar pathogenic changes, in particular, with atrial fibrillation development.…”